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Displaying results 2811 - 2820 of 10000 in total
  1. Drug

    Tisagenlecleucel

    go.drugbank.com/drugs/DB13881
    ApprovedInvestigational

    It was granted approval by FDA in August 2017 under the market name Kymriah. … These CD19-directed chimeric antigen receptors (CD19 CAR-T cells) direct the T cells to target and kill leukemia cells that express CD19 on the cell surface.

    Synonyms: Tisagenlecleucel-T, CAR.CD19-Redirected T cellsCategories: Genetically-modified Autologous T Cells
  2. Drug

    Ranirestat

    go.drugbank.com/drugs/DB05327
    Investigational

    Ranirestat is a structurally novel and stereospecifically potent aldose reductase (AKR1B; EC 1.1.1.21) inhibitor, which contains a succinimide ring that undergoes ring-opening at physiological pH levels … It has been used in trials studying the treatment of Mild to Moderate Diabetic Sensorimotor Polyneuropathy.

  3. Drug

    Rimexolone

    go.drugbank.com/drugs/DB00896
    ApprovedWithdrawn

    It is used to treat inflammation in the eye. It is marketed as Vexol.

  4. Drug

    Tosedostat

    go.drugbank.com/drugs/DB11781
    Investigational

    It entered the clinical trial in patients with haematological malignancies. … It has demonstrated anti-tumour activity in a number of models of cancer, both as a single agent and in synergy with cytotoxic agents such as carboplatin and paclitaxel.

  5. Drug

    Dronedarone

    go.drugbank.com/drugs/DB04855
    ApprovedInvestigational

    It is managed by rate control, rhythm control, prevention of thromboembolic events, and treatment of the underlying disease. … [T28] Commonly marketed as Multaq®, dronedarone was approved by the FDA in July 2009 and Health Canada in August 2009.

    Synonyms: N-(2-butyl-3-(4-(3-(dibutylamino)propoxy)benzoyl)-5-benzofuranyl)-methanesulfonamide, N-(2-butyl-3-(p-(3-(dibutylamino)propoxy)benzoyl)-5-benzofuranyl)methanesulfonamideProducts: MULTAQ (400 MG), MULTAQ 400 MG FILM-COATED TABLETS
  6. Drug

    Perhexiline

    go.drugbank.com/drugs/DB01074
    Approved

    It may cause neuropathy and hepatitis.

  7. Drug

    2,4-Dinitrophenol

    go.drugbank.com/drugs/DB04528
    Experimental

    It is also used as a metabolic stimulant. (Stedman, 26th ed) … A toxic dye, chemically related to trinitrophenol (picric acid), used in biochemical studies of oxidative processes where it uncouples oxidative phosphorylation.

    Categories: Compounds used in a research, industrial, or household setting
  8. Drug

    Iproclozide

    go.drugbank.com/drugs/DB09247
    ApprovedWithdrawn

    Although it was employed as an antidepressant for a time, the fact that the agent is capable of causing fulminant hepatitis and that its use has been documented as the cause for at least three reported … fatalities has resulted ultimately in the agent being discontinued.

  9. Drug

    Econazole

    go.drugbank.com/drugs/DB01127
    Approved

    It is used topically in dermatomycoses also orally and parenterally.

    Mixtures: TRILON-E CREAMProducts: Pevaryl 10 mg/g Creme, Gyno-Pevaryl 10 mg/g Vaginalcreme
  10. Drug

    Ethoxzolamide

    go.drugbank.com/drugs/DB00311
    ApprovedWithdrawn

    Ethoxzolamide is a sulfonamide used as diuretic and in glaucoma. It inhibits carbonic anhydrase activity in proximal renal tubules to decrease reabsorption of water, sodium, potassium, bicarbonate.