Rimexolone

DB00896ApprovedWithdrawnSmall moleculeCorticosteroids

Rimexolone is a glucocorticoid used to treat inflammation of the eye. Rimexolone is a 1% eye drop solution is a glucocorticoid steroid.

Mechanism: Rimexolone is a glucocorticoid receptor agonist. The antiinflammatory actions of corticosteroids are thought to involve lipocortins, phospholipase A2 inhibitory proteins which, through inhibition of arachidonic acid, control the biosynthesis of prostaglandins and leukotrienes. By binding to the glucocorticoid receptor, this drug ultimately leads to changes in genetic transcription involving the lipocortins and prostaglandins.
Curator reviewed
Primary indication: For the treatment of postoperative inflammation following ocular surgery and in the treatment of anterior uveitis.Curator reviewed · 2 structured indications
Formula / weight: C₂₄H₃₄O₃ · 370.533 g/mol (avg)
First approval: Canada, 1996 · United States, 1995
Also known as: Rimexolon
Code names: Org 6216

Resolves to

Compound

UNIIO7M2E4264DCAS49697-38-3ChEMBLCHEMBL1200617ChEBI135566PubChem5311412KEGGD05729

Clinical / RWD

RxNorm55681ATCH02AB12ATCS01BA13PharmGKBPA164752251

Structure

InChIKeyQTTRZHGPGKRAFB-OOKHYKNYSA-NSMILES[H][C@@]12C[C@@H](C)[C@](C)(C(=O)CC)[C@@]1(C)C[C@H](O)[C@@]1([H])[C@@]2([H])CCC2=CC(=O)C=C[C@]12C

Targets

P04150NR3C1P11474ESRRA

What you can answer from here — as of September 23, 2026

2Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

271Drug interactionsStructured to mechanism, not free text

2Clinical trialsPhase, status and sponsor resolved per trial

2Structured indicationsCondition, population, route and combination as fields, not prose

8ContraindicationsEach with its own population and attribute set

4Marketed productsAcross 4 countries and 3 labellers

2ATC codesIncluding every combination product, plus 27 drug categories

7+ReferencesStructured and connected to the statements they support

Which drugs share a target with Rimexolone, and which of those have an active Phase 3 trial?

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