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Futibatinib
go.drugbank.com/drugs/DB15149ApprovedInvestigationalFutibatinib is an inhibitor of Fibroblast Growth Factor receptor (FGFR), which comprises a group of receptor tyrosine kinases that play a key role in cell proliferation, differentiation, migration, and … [L43347] On July 4, 2023, the European Commission granted Conditional Marketing Authorization for futibatinib for the treatment of cholangiocarcinoma.[L47800]
Categories: Fibroblast growth factor receptor (FGFR) tyrosine kinase inhibitors, P-glycoprotein inhibitorsBromfenac
go.drugbank.com/drugs/DB00963ApprovedWithdrawnTheir well-characterized anti-inflammatory activity, analgesic property, and established safety record have also made NSAIDs an important tool for optimizing surgical outcomes. … Bromfenac is a nonsteroidal anti-inflammatory drug (NSAID) for ophthalmic use. Ophthalmic NSAIDs are becoming a cornerstone for the management of ocular pain and inflammation.
Synthetic Conjugated Estrogens, B
go.drugbank.com/drugs/DB09318ApprovedThis shift in hormone production is largely responsible for many of the symptoms experienced during and after menopause and includes hot flashes and other vasomotor symptoms, painful intercourse, vaginal … This blend of ten estrogen derivatives are plant-derived forms of endogenous estrogens and contain many of the same compounds as the Conjugated Equine Estrogens (CEEs), although they are not considered
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesClodronic acid
go.drugbank.com/drugs/DB00720ApprovedInvestigationalVet approvedClodronic acid is a first generation bisphosphonate similar to etidronic acid and tiludronic acid. These drugs were developed to mimic the action of pyrophosphate, a regulator of calcification and decalcification. clodronate’s use has de...
Categories: Drugs for Treatment of Bone DiseasesTrimethaphan
go.drugbank.com/drugs/DB01116ApprovedInvestigationalA nicotinic antagonist that has been used as a ganglionic blocker in hypertension, as an adjunct to anesthesia, and to induce hypotension during surgery.
Nuclear receptor subfamily 1 group I member 2
go.drugbank.com/bio_entities/BE0000956TargetHumansNuclear receptor that acts as a transcription factor regulating genes involved in the metabolism and excretion of xenobiotics, drugs, and endogenous compounds. … Upon ligand binding, translocates to the nucleus, forms a heterodimer with the retinoid X receptor/RXR, and binds to response elements in target promoters, leading to transcriptional activation.
Polypeptides: Nuclear receptor subfamily 1 group I member 2Synonyms: Pregnane X receptor, Orphan nuclear receptor PAR1Gamma-aminobutyric acid type B receptor subunit 2
go.drugbank.com/bio_entities/BE0002340TargetHumansPre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating … Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins (PubMed:18165688).
Polypeptides: Gamma-aminobutyric acid type B receptor subunit 2Synonyms: GABA-B receptor 2, G protein-coupled receptor 51Nuclear receptor subfamily 1 group I member 3
go.drugbank.com/bio_entities/BE0003848TargetHumansBinds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes.
Polypeptides: Nuclear receptor subfamily 1 group I member 3Synonyms: Orphan nuclear receptor MB67, Constitutive androstane receptorPeroxisome proliferator-activated receptor gamma coactivator 1-beta
go.drugbank.com/bio_entities/BE0009812TargetHumansActivates transcriptional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. … May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed.
Polypeptides: Peroxisome proliferator-activated receptor gamma coactivator 1-betaSynonyms: PGC-1-related estrogen receptor alpha coactivatorLeukocyte immunoglobulin-like receptor subfamily B member 2
go.drugbank.com/bio_entities/BE0010561TargetHumansReceptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles (PubMed:11169396, PubMed:12853576, PubMed:16455647, PubMed:20448110, PubMed:27859042).
Polypeptides: Leukocyte immunoglobulin-like receptor subfamily B member 2Synonyms: Leukocyte immunoglobulin-like receptor 2, Monocyte/macrophage immunoglobulin-like receptor 10