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Ofatumumab
go.drugbank.com/drugs/DB06650ApprovedInvestigationalIt is an IgG1κ human monoclonal antibody produced from a recombinant murine cell line (NS0) via transgenic mouse and hybridoma technology. … [A6921] Ofatumumab was first approved by the FDA in 2009.
Drometrizole trisiloxane
go.drugbank.com/drugs/DB11585ApprovedDespite being used elsewhere in the world with relatively few reports of adverse reactions, the FDA continues to cite that the existing scientific record is not sufficient to establish the compound as … The compound is a lipophilic benzotriazole derivative marketed as Meroxyl XL by L'Oreal, although sunscreens with drometrizole trisiloxane are currently only approved for use in the EU, Canada, Australia
Mixtures: Garnier Ombrelle Kids Wet N Protect Hypoallergenic SPF 45 Mexoryl Technology, Garnier Ombrelle Kids Wet N Protect Hypoallergenic SPF 45 Mexoryl TechnologyDaridorexant
go.drugbank.com/drugs/DB15031ApprovedInvestigational[A244225] It was approved by the FDA on January 10, 2022, under the name QUVIVIQ.[L39660] as the second orexin receptor antagonist approved to treat insomnia following [suvorexant]. … [A244225] Daridorexant works on orexin receptors OX1R and OX2R to block the binding of orexins, which are wake-promoting neuropeptides and endogenous ligands to these receptors.
NKG2D-ACE2 CAR-NK Cell
go.drugbank.com/drugs/DB15727InvestigationalThese cells are prepared as universal off-the-shelf CAR-NK cells from cord blood with NKG2D-ACE2 proteins engineered as part of the CARs; the cell secretes IL-15 and GM-CSF. … First used with autologous human T cells (CAR-T) as cancer immunotherapies, these receptors are now being engineered onto natural killer (NK) cells due to lower potential for graft-versus-host disease
Synonyms: ACE2 CAR-NK Cell, NKG2D CAR-NK CellBacillus calmette-guerin substrain connaught live antigen
go.drugbank.com/drugs/DB10804ApprovedInvestigationalWithdrawnIt is prepared from the Connaught strain of Bacillus Calmette and Guérin. … and/or T1 papillary tumors following transurethral resection (TUR).
Methylcellulose
go.drugbank.com/drugs/DB11228ApprovedInvestigationalMethyl cellulose is a hydrophilic white powder in pure form and dissolves in cold (but not in hot) water, forming a clear viscous solution or gel. … The Degree of Substitution (DS) of a given form of methyl cellulose is defined as the average number of substituted hydroxyl groups per glucose with a theoretical maximum of 3, however more typical values
Elagolix
go.drugbank.com/drugs/DB11979ApprovedInvestigationalMoreover, women who are affected by this condition can suffer for up to six to ten years and visit multiple physicians before receiving a proper diagnosis [A35868, A35869, F801]. … Administration (FDA) approved AbbVie's elagolix under the brand name Orilissa as the first and only oral gonadotropin-releasing hormone (GnRH) antagonist specifically developed for women with moderate to
MUC1 Dendritic Cell Vaccine
go.drugbank.com/drugs/DB05477InvestigationalThese cells are then given back to a patient as a vaccine in order to allow for a potent immune response to cancer. … Dendritic cells not only activate lymphocytes to induce the immune response, but they also minimize autoimmune reactions by downplaying self-antigens to stimulated T-cells.
Interferon alfa-n3
go.drugbank.com/drugs/DB00018ApprovedPurified, natural (n is for natural) human interferon alpha proteins (consists of 3 forms or polymorphisms including 2a, 2b and 2c). 166 residues, some are glycosylated (MW range from 16 kD to 27 kD).
Synonyms: Interferon alfa-n3International brands: Alferon NVinflunine
go.drugbank.com/drugs/DB11641ApprovedInvestigationalVinflunine is a microtubule inhibitor that binds to tubulin at or near to the vinca binding sites to inhibits its polymerization into microtubules during cell proliferation [L1396]. … Some patients with advanced urothelial carcinoma experience inadequate therapeutic response from a prior platinum-containing regimen.