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Amsilarotene
go.drugbank.com/drugs/DB21085InvestigationalAmsilarotene is under investigation in clinical trial NCT00687596 (Study of TAC-101 as Second Line Treatment in Patients With Advanced Hepatocellular Carcinoma Who Received Sorafenib as First Line Therapy … Amsilarotene has a monoisotopic molecular weight of 385.15 Da.
Mechlorethamine
go.drugbank.com/drugs/DB00888ApprovedInvestigational) in patients who have received prior skin-directed therapy. … The hydrochloride is used as an antineoplastic in Hodgkin's disease and lymphomas. It causes severe gastrointestinal and bone marrow damage.
Categories: Compounds used in a research, industrial, or household setting, Weapons of Mass DestructionSynonyms: β,β'-dichlorodiethyl-N-methylamine, N-methyl-bis(2-chloroethyl)amineBromothalonil
go.drugbank.com/drugs/DB14199ApprovedIt is also a known allergen and dermatological irritant that has been banned in many EU countries due to increasing rates of contact allergy [A34322]. … Bromothalonil, also known as Methyldibromo glutaronitrile (MDBGN), is a widely used preservative that can be found in many personal hygiene and industrial products.
Categories: Compounds used in a research, industrial, or household settingSynonyms: 2-Bromo-2-(bromomethyl) glutaronitrile, 2-Bromo-2-(bromomethyl) pentanedinitrileTerfenadine
go.drugbank.com/drugs/DB00342ApprovedWithdrawnIn the U.S., Terfenadine was superseded by fexofenadine in the 1990s due to the risk of cardiac arrhythmia caused by QT interval prolongation.
Categories: P-glycoprotein inhibitors, P-glycoprotein substratesSynonyms: (RS)-1-(4-tert-butylphenyl)-4-{4-[hydroxy(diphenyl)methyl]piperidin-1-yl}-butan-1-olViral Macrophage-Inflammatory Protein
go.drugbank.com/drugs/DB15748ExperimentalViral macrophage inflammatory protein-II (vMIP) is a highly basic protein and human chemokine analog encoded by human herpesvirus-8. … The structure of vMIP consists of 71 residues and is a monomer under most conditions.
Synonyms: vMIP-II, Viral Macrophage Inflammatory Protein-IISibutramine
go.drugbank.com/drugs/DB01105ApprovedIllicitWithdrawnIn October 2010, Sibutramine was withdrawn from Canadian and U.S. markets due to concerns that the drug increases the risk of heart attack and stroke in patients with a history of heart disease. … It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled substance in the United States.
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome, Combined Inhibitors of Serotonin/Norepinephrine ReuptakeProducts: TALLARME®, OBESTOP® 10 MG CAPSULASPentoxyverine
go.drugbank.com/drugs/DB11186ApprovedWithdrawnIt is an active ingredient in over-the-counter cough suppressants in combination with guaifenesin and H1-receptor antagonists [A32160]. … Pentoxyverine acts on sigma-1 receptors, as well as kappa and mu-opioid receptors. The FDA withdrew the use of all oral gel drug products containing pentoxyverine citrate.
Mixtures: Exall D, Zotex-DSoy isoflavones
go.drugbank.com/drugs/DB14101ApprovedMixtures: D-Cal SoyCal, CALCIBON D SOYA FORTE TABLETASProducts: FITOFLAVONA® 35 MG, APROLAC® 80 MGTABLETASBromhexine
go.drugbank.com/drugs/DB09019ApprovedInvestigationalIt is derived from the Adhatoda vasica plant and aids in the clearance of excess mucus, improving breathing and reducing cough. … It was introduced into the market in 1963, and is widely available as an over-the-counter drug in many countries.
Mixtures: GLICERTOX N F, TUKOL® D SOLUCION ORALSynonyms: N-cyclohexyl-N-methyl-(2-amino-3,5-dibrombenzyl)amine, 3,5-dibromo-N(alpha)-cyclohexyl-N(alpha)-methyltoluene-alpha-2-diamineDaclizumab
go.drugbank.com/drugs/DB00111ApprovedInvestigationalWithdrawnon 2 March 2018 [L1738]. … in de novo allogeneic renal transplantation and used concomitantly with an immunosuppressive regimen like cyclosporine and corticosteroids in patients who are not hight immunized, for commercial reasons
Categories: Interleukin-2 Receptor Antagonist, Interleukin-2 Receptor Blocking Antibody