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Displaying results 2871 - 2880 of 6951 in total
  1. Drug

    Irbesartan

    go.drugbank.com/drugs/DB01029
    ApprovedInvestigational

    [L7456,L7459] It can also be used as part of a combination product with [hydrochlorothiazide] for patients not well controlled or not expected to be well controlled on monotherapy. … Irbesartan is an angiotensin receptor blocker (ARB) indicated to treat hypertension or diabetic nephropathy.

    Categories: Antihypertensive Agents Indicated for Hypertension, Angiotensin 2 Receptor Blocker
  2. Drug

    Pyridoxal phosphate

    go.drugbank.com/drugs/DB00114
    ApprovedInvestigationalNutraceutical

    This is the active form of vitamin B6 serving as a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid.

  3. Drug

    Zunsemetinib

    go.drugbank.com/drugs/DB16502
    Investigational

    Zunsemetinib is being investigated in a new clinical trial (NCT06374459) for the treatment of hormone receptor-positive and HER2-negative metastatic breast cancer with bone metastasis. … ATI-450 was under investigation in clinical trials (NCT05279417 and NCT05216224) for treating patients with rheumatoid arthritis and hidradenitis suppurativa, respectively.

    Categories: Experimental Unapproved Treatments for COVID-19
  4. Target

    Cubilin

    go.drugbank.com/bio_entities/BE0000936
    TargetTransporterHumans

    Endocytic receptor which plays a role in lipoprotein, vitamin and iron metabolism by facilitating their uptake (PubMed:10371504, PubMed:11606717, PubMed:11717447, PubMed:14576052, PubMed:9572993).

    Synonyms: 460 kDa receptor, Intestinal intrinsic factor receptor
  5. Drug

    Mesalazine

    go.drugbank.com/drugs/DB00244
    ApprovedInvestigational

    Although demonstrably effective in treating and maintaining remission for ulcerative colitis, mesalazine has historically faced a number of issues regarding its lack of stability as a pharmaceutical agent

  6. Drug

    Daprodustat

    go.drugbank.com/drugs/DB11682
    ApprovedInvestigational

    anemia of CKD but not for non-dialysis patients with anemia of CKD. … [A254172] In June 2020, daprodustat was first approved in Japan for the treatment of renal anemia.

  7. Drug

    Midostaurin

    go.drugbank.com/drugs/DB06595
    ApprovedInvestigational

    Midostaurin (as Rydapt) is a multitarget kinase inhibitor for the treatment for adult patients with newly diagnosed acute myeloid leukemia (AML) who have a specific genetic mutation called FLT3.

    Categories: Receptor Tyrosine Kinase Inhibitors
  8. Drug

    Gepirone

    go.drugbank.com/drugs/DB12184
    Approved

    It was not until an extended-release formulation of gepirone was made available that gepirone became a potential candidate for a new antidepressant. … [A261670,A261675,A182315] Gepirone was approved by the FDA on September 28, 2023, under the brand name EXXUA for the treatment of adults with major depressive disorder.

    Categories: Serotonin Receptor Agonists
  9. Drug

    Vindesine

    go.drugbank.com/drugs/DB00309
    ApprovedInvestigationalWithdrawn

    Vinblastine derivative with antineoplastic activity against cancer. Major side effects are myelosuppression and neurotoxicity. Vindesine is used extensively in chemotherapy protocols (antineoplastic combined chemotherapy protocols).

  10. Drug

    Faldaprevir

    go.drugbank.com/drugs/DB11808
    Investigational

    Faldaprevir has been investigated for the treatment of Chronic Hepatitis C.

    Categories: Antivirals for Systemic Use, Antiinfectives for Systemic Use