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Displaying results 281 - 290 of 1203 in total
  1. Drug

    OT-730

    go.drugbank.com/drugs/DB16112
    Investigational

    OT-730 is under investigation in clinical trial NCT00753168 (Phase 1-2 Evaluation of OT-730 Eye Drops in Reducing the Intraocular Pressure in Patients With Ocular Hypertension or Open-angle Glaucoma).

  2. Drug

    Voretigene neparvovec

    go.drugbank.com/drugs/DB13932
    ApprovedInvestigational

    Voretigene Neparvovec-rzyl (VN-rzyl) is an adeno-associated virus vector-based gene therapy. An adeno-associated virus is a small virus that infects humans and other primates. It is not pathogenic and it causes a very mild immune respons...

  3. Drug

    Fenobam

    go.drugbank.com/drugs/DB12931
    Investigational

    Fenobam is under investigation in clinical trial NCT00637221 (Open Label Study Investigating Safety and Efficacy of Fenobam anhydrous 50 mg - 150 mg on Prepulse Inhibition Tests and Continuous Performance

  4. Drug

    Tavolixizumab

    go.drugbank.com/drugs/DB15042
    Investigational

    Tavolixizumab is under investigation in clinical trial NCT02318394 (A Phase 1 Study of MEDI0562 in Adult Subjects With Selected Advanced Solid Tumors).

    Synonyms: IMMUNOGLOBULIN G1-KAPPA, ANTI-(HOMO SAPIENSTNFRSF4 (TUMOR NECROSIS FACTOR RECEPTOR (TNFR) SUPERFAMILY MEMBER 4, OX40, CD134)), HUMANIZED AND CHIMERIC MONOCLONAL ANTIBODY GAMMA1 HEAVY CHAIN (1-451) (CHIMERIC
  5. Target

    Insulin receptor

    go.drugbank.com/bio_entities/BE0000033
    TargetHumans

    When present in a hybrid receptor with IGF1R, binds IGF1. … Receptor tyrosine kinase which mediates the pleiotropic actions of insulin.

    Polypeptides: Insulin receptor
  6. Target

    Estrogen receptor

    go.drugbank.com/bio_entities/BE0000123
    TargetHumans

    Nuclear hormone receptor. … Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner.

    Polypeptides: Estrogen receptorSynonyms: Estradiol receptor, Nuclear receptor subfamily 3 group A member 1
  7. Target

    Secretin receptor

    go.drugbank.com/bio_entities/BE0000318
    TargetHumans

    G protein-coupled receptor activated by secretin (SCT), which is involved in different processes such as regulation of the pH of the duodenal content, food intake and water homeostasis (PubMed:25332973 … Mechanistically, secretin released by the gut after a meal binds to secretin receptor (SCTR) in brown adipocytes, activating brown fat thermogenesis by stimulating lipolysis, which is sensed in the brain

    Polypeptides: Secretin receptorFunction: G protein-coupled peptide receptor activity
  8. Target

    Prolactin receptor

    go.drugbank.com/bio_entities/BE0000345
    TargetHumans

    This is a receptor for the anterior pituitary hormone prolactin (PRL).

    Polypeptides: Prolactin receptor
  9. Target

    Thyrotropin receptor

    go.drugbank.com/bio_entities/BE0000490
    TargetHumans

    Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin (PubMed:11847099, PubMed:12045258). … Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin (PubMed:12045258).

    Polypeptides: Thyrotropin receptorSynonyms: Thyroid-stimulating hormone receptor
  10. Target

    Progesterone receptor

    go.drugbank.com/bio_entities/BE0000557
    TargetHumans

    Depending on the isoform, progesterone receptor functions as a transcriptional activator or repressor

    Polypeptides: Progesterone receptorSynonyms: Nuclear receptor subfamily 3 group C member 3