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Displaying results 2921 - 2930 of 10000 in total
  1. Drug

    Mafenide

    go.drugbank.com/drugs/DB06795
    ApprovedVet approvedWithdrawn

    In November 2022, the use of mafenide acetate (powder for 5% topical solution) was withdrawn by the FDA due to an unresolved confirmatory study required to fulfill the accelerated approval requirements … Mafenide is a sulfonamide-type antimicrobial agent used to treat severe burns. It acts by reducing the bacterial population present in the burn tissue and promotes healing of deep burns.

  2. Drug

    Quinine

    go.drugbank.com/drugs/DB00468
    ApprovedInvestigational

    An alkaloid derived from the bark of the cinchona tree. … It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633.

  3. Drug

    Levamisole

    go.drugbank.com/drugs/DB00848
    ApprovedInvestigationalVet approvedWithdrawn

    [A178117, A178123] Levamisole was withdrawn from the American market in 2000 due to its ability to cause serious adverse effects, including agranulocytosis. … [L6232] Prior to this, levamisole was used as an antirheumatic therapy in the 1970s and 1980s for patients with rheumatoid arthritis.

  4. Drug

    Penicillium expansum

    go.drugbank.com/drugs/DB10810
    Approved

    Penicillium expansum is a fungus which can provoke allergic reactions. Penicillium expansum extract is used in allergenic testing.

    Mixtures: Number Ten Mold Mixture, Number Ten Mold Mixture
  5. Target

    Cubilin

    go.drugbank.com/bio_entities/BE0000936
    TargetTransporterHumans

    Endocytic receptor which plays a role in lipoprotein, vitamin and iron metabolism by facilitating their uptake (PubMed:10371504, PubMed:11606717, PubMed:11717447, PubMed:14576052, PubMed:9572993).

    Synonyms: 460 kDa receptor, Intestinal intrinsic factor receptor
  6. Drug

    Irinotecan

    go.drugbank.com/drugs/DB00762
    ApprovedInvestigational

    This leads to the arrest of the cell cycle in the S-G2 phase and cancer cell death.[A263376] … [A263376] The bis-piperidine side chain in the structure of irinotecan bestows enhanced water solubility.

    Products: CLORHIDRATO DE IRINOTECAN TRIHIDRATO 20 MG/ML
  7. Drug

    Carglumic acid

    go.drugbank.com/drugs/DB06775
    ApprovedInvestigational

    Carglumic acid was approved by the U.S. Food and Drug Administration (FDA) on 18 March 2010. … Carglumic acid is a drug used for the treatment of hyperammonemia in patients with a deficiency in N-acetyl glutamate synthase.

  8. Drug

    Efbemalenograstim alfa

    go.drugbank.com/drugs/DB18704
    ApprovedInvestigational

    alfa can stimulate the production of neutrophils and thus reducing the severity and duration of neutropenia. … Efbemalenograstim alfa is a long-acting recombinant fusion protein of granulocyte-colony stimulating factor (G-CSF) due to the addition of the Fc portion of human IgG2, allowing for once-per-cycle administration

  9. Drug

    Dimercaprol

    go.drugbank.com/drugs/DB06782
    Approved

    In addition, it has in the past been used for the treatment of Wilson's disease, a genetic disorder in which the body tends to retain copper. … Dimercaprol has toxic potential, and its use may be followed by a variety of adverse effects.

  10. Drug

    Besilesomab

    go.drugbank.com/drugs/DB13979
    Approved

    Netherlands, and the United Kingdom [L1564]. … Besilesomab is a mouse monoclonal antibody labelled with the radioactive isotope technetium-99m for determining the location of inflammation/infection in peripheral bone in adults with suspected osteomyelitis

    Salts: Technetium Tc-99m besilesomab