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Sulfamethazine
go.drugbank.com/drugs/DB01582ApprovedVet approvedWithdrawnA sulfanilamide anti-infective agent. It has a spectrum of antimicrobial action similar to other sulfonamides.
Synonyms: (p-Aminobenzolsulfonyl)-2-amino-4,6-dimethylpyrimidin, 2-(p-Aminobenzenesulfonamido)-4,6-dimethylpyrimidineCategories: Antibacterials for Systemic Use, Antiinfectives for Systemic UseGolodirsen
go.drugbank.com/drugs/DB15593ApprovedInvestigationalThis is an X-linked condition leading to progressive muscle degeneration that begins in early childhood, rendering many patients wheelchair-bound by age 12. … [L10755,L10758] Golodirsen was initially rejected for FDA approval over concerns about its potential renal toxicity, however, clinical trials did not show significant toxicity.[L10755]
Tafamidis
go.drugbank.com/drugs/DB11644ApprovedInvestigational[A189717] Tafamidis was granted an EMA market authorisation on 16 November 2011[L6247] and FDA approval on 3 May 2019.[L11280]
Tetracaine
go.drugbank.com/drugs/DB09085ApprovedInvestigationalVet approvedTetracaine is an ester local anaesthetic currently available in combination with lidocaine as a cream and patch.
Categories: Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use, Anesthetics for Topical UseSynonyms: 2-(Dimethylamino)ethyl p-(butylamino)benzoate, p-Butylaminobenzoyl-2-dimethylaminoethanolTisotumab vedotin
go.drugbank.com/drugs/DB16732ApprovedInvestigationalIt is also being investigated for the combination use with other chemotherapeutic agents for recurrent or metastatic cervical cancer.[A238924] … This is the first and only approved antibody-drug conjugate for this therapeutic indication.
Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesCynodon dactylon pollen
go.drugbank.com/drugs/DB10351ApprovedIt can be cutaneously, intradermally and subcutaneously administered to initiate an immune response in case of an allergic reaction. … Cynodon dactylon pollen, also known as bermuda grass pollen, is a standardized grass pollen extracts used for the diagnosis and treatment of allergic disease to grass pollen.
Amifampridine
go.drugbank.com/drugs/DB11640ApprovedAmifampridine phosphate is a more stable salt that serves as an active ingredient of EMA-approved Firdapse, which was previously marketed as Zenas. … Patients with LEMS develop serum antibodies against presynaptic P/Q-type voltage-gated calcium channels, leading to decreased presynaptic calcium levels and reduced quantal release of acetylcholine, which
Everolimus
go.drugbank.com/drugs/DB01590ApprovedInvestigationalIt is currently used as an immunosuppressant to prevent rejection of organ transplants. … Everolimus is a derivative of Rapamycin (sirolimus), and works similarly to Rapamycin as an mTOR (mammalian target of rapamycin) inhibitor.
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesProducts: Certican 0,1 mg - Tabletten zur Herstellung einer Suspension zum Einnehmen, Certican 0,25 mg - Tabletten zur Herstellung einer Suspension zum EinnehmenTransient receptor potential cation channel subfamily V member 1
go.drugbank.com/bio_entities/BE0001023TargetHumansActs as ionotropic endocannabinoid receptor with central neuromodulatory effects. … Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia.
Polypeptides: Transient receptor potential cation channel subfamily V member 1Synonyms: Capsaicin receptor, Vanilloid receptor 1Low affinity immunoglobulin gamma Fc region receptor II-a
go.drugbank.com/bio_entities/BE0002098TargetHumansLow affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens. Promotes phagocytosis of opsonized antigens
Polypeptides: Low affinity immunoglobulin gamma Fc region receptor II-aSynonyms: IgG Fc receptor II-a