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Durlobactam
go.drugbank.com/drugs/DB16704ApprovedInvestigationalIt is typically given in combination with [sulbactam] to protect it from degradation by certain serine-beta-lactamases. … [A263306] It is used to treat hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumonia (HABP/VABP), caused by susceptible isolates of _Acinetobacter baumannii-calcoaceticus_
Amineptine
go.drugbank.com/drugs/DB04836ApprovedIllicitWithdrawnThe Food and Drug Administration suspended the marketing authorisation for Survector in 1999 and France withdrew it from the market, however several developing countries continued to produce it up until
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeCethromycin
go.drugbank.com/drugs/DB06419Investigational[L14006, A203369] However, after completing phase III clinical trials, it was deemed safe but not sufficiently efficacious by the FDA. … [A203369] Cethromycin represents a joint development effort by Abbott Laboratories, Taisho Pharmaceuticals, and Advanced Life Sciences, intended to be marketed under the trade name Restanza for the treatment
Neratinib
go.drugbank.com/drugs/DB11828ApprovedInvestigationalApproval was granted to Puma Biotechnology Inc. for the tradename Nerlynx. Neratinib is currently under investigation for use in many other forms of cancer. … Neratinib was approved in July 2017 for use as an extended adjuvant therapy in Human Epidermal Growth Factor Receptor 2 (HER2) positive breast cancer.
Icaridin
go.drugbank.com/drugs/DB14074InvestigationalIcaridin is reported to be less irritating than [Diethyltoluamide], another common insect repellant, and products containing up to 20% of icaridin are considered safe for long-term use in adults [A39231 … It is considered to be the first choice of repellent by the Public Health Agency of Canada’s Canadian Advisory Committee on Tropical Medicine and Travel for travelers six months to 12 years of age [A39203
Categories: Compounds used in a research, industrial, or household settingBenzonatate
go.drugbank.com/drugs/DB00868Approved[L11193] Although it not prone to drug misuse or abuse, benzonatate is associated with a risk for severe toxicity and overdose, especially in children.[A189513] … [A189519] It works to reduce the activity of cough reflex by desensitizing the tissues of the lungs and pleura involved in the cough reflex.
Synonyms: p-butylaminobenzoic acid ω-O-methylnonaethyleneglycol esterIsotretinoin
go.drugbank.com/drugs/DB00982ApprovedInvestigationalIsotretinoin is a retinoid derivative of vitamin A used in the treatment of severe recalcitrant acne.[Label] It was most widely marketed under the brand name Accutane, which has since been discontinued. Isotretinoin is associated with ma...
Categories: Retinoids for Treatment of Acne, Anti-Acne Preparations for Systemic UseClobazam
go.drugbank.com/drugs/DB00349ApprovedIllicitInvestigational[A521,A522] In October 21, 2011, the FDA approved clobazam as an adjunctive treatment for seizures associated with Lennox-Gastaut syndrome in adults and children aged two years and older. … [A256868] Additionally, clobazam is believed to be a partial agonist to the GABA<sub>A</sub> receptor rather than non-selective full receptor agonists like 1,4-benzodiazepines, thus potentially explaining
Adefovir dipivoxil
go.drugbank.com/drugs/DB00718ApprovedAdefovir dipivoxil, previously called bis-POM PMEA, with trade names Preveon and Hepsera, is an orally-administered acyclic nucleotide analog reverse transcriptase inhibitor (ntRTI) used for treatment
Categories: Antivirals for Systemic Use, Antiinfectives for Systemic UseDiosmin
go.drugbank.com/drugs/DB08995ApprovedInvestigationalCompression and pharmacotherapy are frequently used to manage chronic venous insufficiency, improving circulation and symptoms of venous disease. … It is used for the improvement of capillary fragility or venous insufficiency, including chronic venous insufficiency (CVI) and hemorrhoids.
Synonyms: Diosmetin 7-O-rutinoside