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Sebelipase alfa
go.drugbank.com/drugs/DB11563ApprovedInvestigationalThe lysosomal acid lipase (LAL) enzyme is found in lysosomes and is primarily responsible for the metabolism of lipids, and its absence or deficiency results in the accumulation of lipids in various organs … This lipid accumulation can lead to end-organ damage in the form of liver dysfunction or malabsorption secondary to intestinal dysfunction.
Human varicella-zoster immune globulin
go.drugbank.com/drugs/DB11621ApprovedInvestigationallack evidence of immunity to varicella and for whom varicella vaccine is contraindicated. … The therapeutic efficacy is proven if administered within 4 days of exposure to varicella zoster virus.
Interferon alfa-n3
go.drugbank.com/drugs/DB00018ApprovedPurified, natural (n is for natural) human interferon alpha proteins (consists of 3 forms or polymorphisms including 2a, 2b and 2c). 166 residues, some are glycosylated (MW range from 16 kD to 27 kD).
International brands: Alferon NUric acid
go.drugbank.com/drugs/DB08844InvestigationalUric acid is the last product of purine metabolism in humans. The formation of uric acid is through the enzyme xanthine oxidase, which oxidizes oxypurines. … Normally a small amount of uric acid is present in the body, but when there is an excess amount in the blood, called hyperuricemia, this can lead to gout and formation of kidney stones.
Categories: Compounds used in a research, industrial, or household settingTestolactone
go.drugbank.com/drugs/DB00894ApprovedWithdrawnAn antineoplastic agent that is a derivative of progesterone and used to treat advanced breast cancer.
Synonyms: D-homo-17a-oxaandrosta-1,4-diene-3,17-dioneBetibeglogene autotemcel
go.drugbank.com/drugs/DB16900ApprovedInvestigationaldonor due to the risks of graft rejection, graft-versus-host disease, and other treatment-related toxic effects. … This affects hemoglobin levels, and in patients with severe forms of this disease, long-term red cell transfusions are required for survival and the prevention of serious complications.
COVID19 s-vax loaded autologous dendritic cell vaccine
go.drugbank.com/drugs/DB15814ExperimentalThe rationale is that loading a DC cell with SARS-Cov-2 antigens and administering it as a vaccine can induce a more prolific immune response. … As of May 2020, the company is pursuing a human clinical trial (ChiCTR2000033003) to test the safety and immunogenicity of the vaccine.
Exagamglogene autotemcel
go.drugbank.com/drugs/DB15572ApprovedInvestigational[A262691] Treatment options for SCD are largely focused on preventing the production and circulation of HbS and inducing the production of normal fetal hemoglobin (HbF),[A262696,A262701] including [hydroxyurea … [L10139] Following engraftment, it causes an increase in the production of HbF and a subsequent decrease in HbS.
Synonyms: from mobilised peripheral blood by positive selection, modified by CRISPR/Cas9 (clustered regularly interspaced short palindromic repeats/CRISPR-associated protein 9) mediated gene editing consisting ofQuinupristin
go.drugbank.com/drugs/DB01369ApprovedDalfopristin inhibits the early phase of protein synthesis in the bacterial ribosome and quinupristin inhibits the late phase of protein synthesis. … The combination of the two components acts synergistically and is more effective in vitro than each component alone.
Estradiol dienanthate
go.drugbank.com/drugs/DB13955ApprovedVet approvedWithdrawnEstradiol is commonly produced with an ester side-chain as endogenous estradiol has very low oral bioavailability on its own (2-10%). … Following absorption, the esters are cleaved, resulting in the release of endogenous estradiol, or 17β-estradiol.