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Gefitinib
go.drugbank.com/drugs/DB00317ApprovedInvestigationalActing in a similar manner to erlotinib (marketed as Tarceva), gefitinib selectively targets the mutant proteins in malignant cells. It is marketed by AstraZeneca under the trade name Iressa. … Gefitinib (originally coded ZD1839) is a drug used in the treatment of certain types of cancer.
Categories: MATE 1 Inhibitors, P-glycoprotein inhibitorsSynonyms: N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-(4-morpholinyl)propoxy)-4-quinazolinamine, 4-(3'-chloro-4'-fluoroanilino)-7-methoxy-6-(3-morpholinopropoxy)quinazolineLifitegrast
go.drugbank.com/drugs/DB11611ApprovedInvestigationalLifitegrast is a FDA approved drug for the treatment of keratoconjunctivitis sicca (dry eye syndrome). … It is a tetrahydroisoquinoline derivative and lymphocyte function-associated antigen-1 ( LFA-1) antagonist that was discovered through the rational design process.
Categories: Cytochrome P-450 CYP2C9 Inhibitors, Cytochrome P-450 Enzyme InhibitorsZuranolone
go.drugbank.com/drugs/DB15490ApprovedInvestigationalbinding to a non-benzodiazepine site on the receptor. … Zuranolone is a neuroactive steroid that acts as a positive allosteric modulator of the GABA<sub>A</sub> receptors.
Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 1-RingEstrone sulfate
go.drugbank.com/drugs/DB04574ApprovedIt has several uses such as: alleviate symptoms of menopause as hormone replacement therapy, treatment some types of infertility, treatment of some conditions leading to underdevelopment of female sexual … Estrone sulfate (as estropipate) is a form of estrogen.
Categories: MATE 1 Substrates, MATE 2 SubstratesSynonyms: Estrone 3-sulfate, Estrone-3-sulphateCastor oil
go.drugbank.com/drugs/DB11113ApprovedNutraceuticalVet approvedCastor oil is a rich source of [DB02955], which represents up to 90% of the total castor oil content. … Due to its renewability and high versatility in addition to being the only commercial source of a hydroxylated fatty acid [A31170], castor oil has been used as a vital raw material for the chemical industry
Mixtures: Polylab Surgical Spirit 98.8% v/v, HydroGold 9Products: Huile De Ricin, De La Cruz Castor OilNandrolone phenpropionate
go.drugbank.com/drugs/DB00984ApprovedIllicitIt is generally prepared from alkyl ethers of estradiol to resemble testosterone but less one carbon at the 19 position. It is a schedule III drug in the U.S.
Acoramidis
go.drugbank.com/drugs/DB17999ApprovedInvestigational[A264768] Although they share a mechanism of action, acoramidis is more selective for TTR and is a more potent stabilizer when compared to tafamidis. … [L51958] Similar to the previously developed [tafamidis], acoramidis is used to stabilize TTR in its tetrameric form, preventing the formation of amyloidogenic monomers and the progression of amyloidosis
Categories: Heterocyclic Compounds, 1-Ring, Cytochrome P-450 CYP2C9 InhibitorsSynonyms: 3-(3-(3,5-dimethyl-1h-pyrazol-4-yl)propoxy)-4-fluorobenzoic acidVanzacaftor
go.drugbank.com/drugs/DB18373ApprovedInvestigationalIt is used alongside other CFTR correctors and CFTR potentiators to increase the quantity and function of CFTR at the cell surface in patients with cystic fibrosis. … ], a CFTR potentiator, for the treatment of patients with responsive CFTR mutations.
Roxadustat
go.drugbank.com/drugs/DB04847ApprovedInvestigationalIt works by reducing the breakdown of the hypoxia-inducible factor (HIF), which is a transcription factor that stimulates red blood cell production in response to low oxygen levels. … [A245393] Roxadustat was first approved by the European Commission in August 2021.[L40323]
Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 2-RingPicosulfuric acid
go.drugbank.com/drugs/DB09268ApprovedInvestigationalPicosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. … The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been used in European countries for many years.[A33322]
Mixtures: CITRAFLEET 0.01 G/ 3.50 G/ 10.97 G ORAL ÇÖZELTI HAZIRLAMAK IÇIN TOZ IÇEREN SAŞE , 2 ADET, PICOPREP 10 MG / 3,5 G /12 G ORAL ÇÖZELTI IÇIN TOZ, 2 SAŞECategories: Heterocyclic Compounds, 1-Ring