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Calcium-activated potassium channel
go.drugbank.com/bio_entities/BE0004906TargetHumansFollowing calcium influx, the consecutive activation of KCNN4 channel leads to a hyperpolarization of the cell membrane potential and hence an increase of the electrical driving force for further calcium … The inward rectification could be due to a blockade of the outward current by intracellular divalent cations such as calcium and magnesium and could also be due to an intrinsic property of the channel
Polypeptides: Calcium-activated potassium channel subunit alpha-1, Calcium-activated potassium channel subunit beta-1Synonyms: Calcium-activated potassium channel subunit beta, Calcium-activated potassium channel, subfamily M subunit alpha-1Calcium/manganese antiporter SLC30A10
go.drugbank.com/bio_entities/BE0009899TransporterHumansCalcium:manganese antiporter of the plasma membrane mediating the efflux of intracellular manganese coupled to an active extracellular calcium exchange (PubMed:30755481). … Could also have an intracellular zinc ion transporter activity, directly regulating intracellular zinc ion homeostasis and more indirectly various signaling pathway and biological processes (PubMed:22427991
Polypeptides: Calcium/manganese antiporter SLC30A10Function: calciumBasement membrane-specific heparan sulfate proteoglycan core protein
go.drugbank.com/bio_entities/BE0001031TargetHumansComponent of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. … It serves as an attachment substrate for cells. Plays essential roles in vascularization. Critical for normal heart development and for regulating the vascular response to injury.
Polypeptides: Basement membrane-specific heparan sulfate proteoglycan core proteinCalcium-dependent secretion activator 1
go.drugbank.com/bio_entities/BE0008704TargetHumansCalcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. … ATP-dependent priming and participates in DCVs-membrane fusion.
Polypeptides: Calcium-dependent secretion activator 1Synonyms: Calcium-dependent activator protein for secretion 1Soluble calcium-activated nucleotidase 1
go.drugbank.com/bio_entities/BE0001746TargetHumansCalcium-dependent nucleotidase with a preference for ribonucleosides diphosphate UDP, GDP and IDP, while having very low activity towards ADP and CDP (PubMed:12234496, PubMed:15006348, PubMed:15248776, … Does not hydrolyze AMP and GMP (PubMed:12234496). Involved in proteoglycan synthesis (PubMed:22539336)
Polypeptides: Soluble calcium-activated nucleotidase 1Calcium-dependent secretion activator 2
go.drugbank.com/bio_entities/BE0008710TargetHumansCalcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. … Regulates neurotrophin release from granule cells leading to regulate cell differentiation and survival during cerebellar development.
Polypeptides: Calcium-dependent secretion activator 2Synonyms: Calcium-dependent activator protein for secretion 2Calcium-dependent protein kinase 4
go.drugbank.com/bio_entities/BE0009256TargetPlasmodium falciparum (isolate 3D7)Calcium-dependent protein kinase which acts as a sensor and effector of intracellular Ca(2+) levels probably in part downstream of cGMP-activated PKG kinase (PubMed:19307175, PubMed:19666141). … Plays a central role in the host erythrocytes and hepatocytes infection cycles, sexual reproduction and mosquito transmission of the parasite.
Polypeptides: Calcium-dependent protein kinase 4Calcium-dependent protein kinase 1
go.drugbank.com/bio_entities/BE0009379TargetPlasmodium falciparum (isolate 3D7)In late schizonts, phosphorylates PKA regulatory subunit PKAr in a calcium-dependent manner, which may contribute to the dissociation of regulatory PKAr and catalytic PKAc subunits and promote the activation … Calcium-dependent protein kinase which acts as a sensor and effector of intracellular Ca(2+) levels probably in part downstream of cGMP-activated PKG kinase (PubMed:18768477, PubMed:19307175, PubMed:28680058
Polypeptides: Calcium-dependent protein kinase 1Plasma membrane calcium-transporting ATPase
go.drugbank.com/bio_entities/BE0009972TargetHumansPlays dual roles in osteoclast differentiation and survival by regulating RANKL-induced calcium oscillations in preosteoclasts and mediating calcium extrusion in mature osteoclasts (By similarity). … May play a role in synaptic transmission by modulating calcium and proton dynamics at the synaptic vesicles
Polypeptides: Plasma membrane calcium-transporting ATPase 1, Plasma membrane calcium-transporting ATPase 2Synonyms: Plasma membrane calcium ATPase isoform 1, Plasma membrane calcium pump isoform 1