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Displaying results 291 - 300 of 10000 in total
  1. Drug

    Fluphenazine

    go.drugbank.com/drugs/DB00623
    Approved

    A phenothiazine used in the treatment of psychoses. Its properties and uses are generally similar to those of chlorpromazine.

    Categories: P-glycoprotein inhibitors, Heterocyclic Compounds, 3-RingSynonyms: 1-(2-hydroxyethyl)-4-(3-(trifluoromethyl-10-phenothiazinyl)propyl)-piperazine, 10-(3'-(4''-(β-hydroxyethyl)-1''-piperazinyl)-propyl)-3-trifluoromethylphenothiazine
  2. Target

    Aldo-keto reductase family 1 member B10

    go.drugbank.com/bio_entities/BE0004353
    TargetEnzymeHumans

    Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols (PubMed:12732097, PubMed:18087047, PubMed:19013440, PubMed:19563777, PubMed:9565553). Displays strong enzymatic ac...

    Synonyms: SI reductase
  3. Drug

    Vincristine

    go.drugbank.com/drugs/DB00541
    ApprovedInvestigational

    Vincristine is an antitumor vinca alkaloid isolated from Vinca Rosea. … Vincristine is indicated for the treatment of acute leukaemia, malignant lymphoma, Hodgkin's disease, acute erythraemia, and acute panmyelosis. vincristine sulfate is often chosen as part of polychemotherapy

    Mixtures: MEODEX®, MEODEX®Categories: CHOP-R chemotherapy regimen, P-glycoprotein substrates with a Narrow Therapeutic Index
  4. Drug

    Carboplatin

    go.drugbank.com/drugs/DB00958
    ApprovedInvestigational

    [A230463,A230523] Carboplatin was granted FDA approval on 3 March 1989.[L32248] … Carboplatin is an organoplatinum antineoplastic alkylating agent used in the treatment of advanced ovarian carcinoma.[L32253] Early clinical studies of carboplatin were performed in 1982.

    Categories: Compounds used in a research, industrial, or household settingSynonyms: Platinum, diammine [1,1-cyclobutane-dicarboxylato(2-)-0,0']-,(SP-4-2), Cis-(1,1-cyclobutanedicarboxylato)diammineplatinum(II)
  5. Drug

    Oxycodone

    go.drugbank.com/drugs/DB00497
    ApprovedIllicitInvestigational

    Oxycodone is a semisynthetic opioid analgesic derived from thebaine in Germany in 1917. … [A178696] It is currently indicated as an immediate release product for moderate to severe pain and as an extended release product for chronic moderate to severe pain requiring continuous opioid analgesics

    Synonyms: 4,5-Epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one, 4,5α-Epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-oneMixtures: TARGIN (R) 10 MG / 5 MG TABLETAS DE LIBERACIÓN PROLONGADA, TARGIN (R) 10 MG / 5 MG TABLETAS DE LIBERACIÓN PROLONGADA
  6. Drug

    Metamizole

    go.drugbank.com/drugs/DB04817
    ApprovedInvestigationalWithdrawn

    Metamizole (dipyrone) is a pyrazolone derivative that belongs to the group of nonacid nonopioids. It is considered a potent analgesic and antipyretic with favourable gastrointestinal tolerability. … [A251805] Metamizole is still used in certain countries in Europe, Asia and South America.[A251805]

    Mixtures: NEURALGIN RX, ANTIALGINA®Categories: Cytochrome P-450 CYP2B6 Inducers, Cytochrome P-450 CYP3A Inducers
  7. Drug

    Tofacitinib

    go.drugbank.com/drugs/DB08895
    ApprovedInvestigational

    Tofacitinib is an inhibitor of Janus kinases, a group of intracellular enzymes involved in signalling pathways that affect hematopoiesis and immune cell function. … Tofacitinib is marketed under the brand name Xeljanz by Pfizer.

    Mixtures: XELJANZ XR, XELJANZ XRCategories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 1-Ring
  8. Drug

    Colloidal oatmeal

    go.drugbank.com/drugs/DB11286
    ApprovedNutraceutical

    It is available in topical products as a skin soothing agent. … Colloidal oatmeal is a FDA-approved skin protectant that temporarily protects and helps relieve minor skin irritation and itching due to rashes, eczema, poison ivy, oak, sumac, or insect bites.

    Mixtures: Pediadermics Eczema 3, 5% Oat Facial CleanserProducts: Seo Sa Hyang Daily Moisture E Tox, Dht X
  9. Drug

    Progesterone

    go.drugbank.com/drugs/DB00396
    ApprovedInvestigationalVet approved

    Pharmaceutical progesterone is made from a plant source as a starting material and is chemically identical to progesterone of human ovarian origin [FDA label]. … Progesterone is a hormone that occurs naturally in females, and is essential for endometrial receptivity, embryo implantation, and the successful establishment of pregnancy.

    Synonyms: (S)-4-Pregnene-3,20-dione, (S)-Pregn-4-en-3,20-dioneInternational brands: Qi Ning
  10. Drug

    Idarubicin

    go.drugbank.com/drugs/DB01177
    ApprovedInvestigational

    An orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity.

    Categories: Topoisomerase II Inhibitors, Cytochrome P-450 CYP2C9 Substrates with a Narrow Therapeutic IndexSynonyms: (1S,3S)-3-acetyl-3,5,12-trihydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydronaphthacen-1-yl 3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranoside, 4-Demethoxydaunomycin