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Avapritinib
go.drugbank.com/drugs/DB15233ApprovedInvestigationalAvapritinib, or BLU-285,[A189327] is a selective tyrosine kinase inhibitor of KIT and platelet derived growth factor receptor alpha indicated for the treatment of unresectable, metastatic gastrointestinal … [A189339,L40363] It is one of the first medications available for the treatment of multidrug resistant cancers.[A189327] Avapritinib shares a similar mechanism with [ripretinib].
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesIopodic acid
go.drugbank.com/drugs/DB09333ApprovedWithdrawnOn September 22, 1981, ipodate was submitted again by the company Schering AG but it is currently under an inactive status.[L1082]
Nirogacestat
go.drugbank.com/drugs/DB12005ApprovedInvestigationalNirogacestat is a small-molecule gamma-secretase inhibitor that was investigated as a potential treatment for desmoid tumors. … [A262556] Interaction between the notch receptors and their ligands activates proteolytic cleavage by gamma-secretase; therefore, the inhibition of gamma-secretase can potentially inhibit Notch signaling
Categories: P-glycoprotein inhibitors, P-glycoprotein substratesElinzanetant
go.drugbank.com/drugs/DB18968ApprovedInvestigational[L53798] Later the same year, it was approved in the US for the same indication. [L54216] … Elinzanetant is a non-hormonal, selective, dual neurokinin 1 (NK-1) and 3 (NK-3) receptor antagonist.
Categories: Substance P/Neurokinin-1 Receptor Antagonist, Cytochrome P-450 CYP3A InhibitorsLow affinity immunoglobulin gamma Fc region receptor III-B
go.drugbank.com/bio_entities/BE0000901TargetHumansReceptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. … May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils
Polypeptides: Low affinity immunoglobulin gamma Fc region receptor III-BSynonyms: IgG Fc receptor III-1Low affinity immunoglobulin gamma Fc region receptor II-b
go.drugbank.com/bio_entities/BE0002099TargetHumansReceptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. … Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor.
Polypeptides: Low affinity immunoglobulin gamma Fc region receptor II-bSynonyms: IgG Fc receptor II-bTransient receptor potential cation channel subfamily V member 6
go.drugbank.com/bio_entities/BE0005102TransporterTargetHumansInactivation includes both a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism; the latter may be regulated by phosphorylation.
Polypeptides: Transient receptor potential cation channel subfamily V member 6Transient receptor potential cation channel subfamily M member 5
go.drugbank.com/bio_entities/BE0020643TargetHumansMonovalent cation-selective ion channel activated by intracellular Ca(2+) in a voltage- and temperature-dependent manner (PubMed:14634208). Mediates the transport of Na(+), K(+) and Cs(+) ions equally well (PubMed:14634208). Activated di...
Polypeptides: Transient receptor potential cation channel subfamily M member 5Synonyms: Long transient receptor potential channel 5Metaxalone
go.drugbank.com/drugs/DB00660ApprovedInvestigationalIts main mechanism of action is thought to involve general central nervous system depression. Metaxalone is associated with few side effects and is available as a 800 mg scored tablet.
Categories: Monoamine Oxidase A Inhibitors for interaction with Monoamine Oxidase A substratesDenileukin diftitox
go.drugbank.com/drugs/DB00004ApprovedInvestigationalDenileukin diftitox is an IL2-receptor-directed cytotoxin, is a recombinant DNA-derived fusion protein composed of the amino acid sequences for diphtheria toxin fragments A and B (Met<sub>1</sub>-Thr<sub … >387</sub>)-His and the sequence for human interleukin-2 (IL-2; Ala<sub>1</sub>-Thr<sub>133</sub>).