Low affinity immunoglobulin gamma Fc region receptor III-B
Details
- Name
- Low affinity immunoglobulin gamma Fc region receptor III-B
- Kind
- protein
- Synonyms
- CD16-I
- CD16B
- Fc-gamma RIII
- Fc-gamma RIII-beta
- Fc-gamma RIIIb
- FCG3
- FCGR3
- FcR-10
- FcRIII
- FcRIIIb
- IGFR3
- IgG Fc receptor III-1
- Gene Name
- FCGR3B
- UniProtKB Entry
- O75015Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0055007|Low affinity immunoglobulin gamma Fc region receptor III-B MWQLLLPTALLLLVSAGMRTEDLPKAVVFLEPQWYSVLEKDSVTLKCQGAYSPEDNSTQW FHNENLISSQASSYFIDAATVNDSGEYRCQTNLSTLSDPVQLEVHIGWLLLQAPRWVFKE EDPIHLRCHSWKNTALHKVTYLQNGKDRKYFHHNSDFHIPKATLKDSGSYFCRGLVGSKN VSSETVNITITQGLAVSTISSFSPPGYQVSFCLVMVLLFAVDTGLYFSVKTNI
- Number of residues
- 233
- Molecular Weight
- 26242.67
- Theoretical pI
- 6.71
- GO Classification
- FunctionsGPI anchor binding / IgG binding / IgG receptor activityProcessesantibody-dependent cellular cytotoxicity / cell surface receptor signaling pathwayComponentsexternal side of plasma membrane / extracellular region / secretory granule membrane
- General Function
- Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils
- Specific Function
- GPI anchor binding
- Pfam Domain Function
- Ig_2 (PF13895)
- Signal Regions
- 1-16
- Transmembrane Regions
- Not Available
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0010636|Low affinity immunoglobulin gamma Fc region receptor III-B (FCGR3B) ATGTGGCAGCTGCTCCTCCCAACTGCTCTGCTACTTCTAGTTTCAGCTGGCATGCGGACT GAAGATCTCCCAAAGGCTGTGGTGTTCCTGGAGCCTCAATGGTACAGCGTGCTTGAGAAG GACAGTGTGACTCTGAAGTGCCAGGGAGCCTACTCCCCTGAGGACAATTCCACACAGTGG TTTCACAATGAGAACCTCATCTCAAGCCAGGCCTCGAGCTACTTCATTGACGCTGCCACA GTCAACGACAGTGGAGAGTACAGGTGCCAGACAAACCTCTCCACCCTCAGTGACCCGGTG CAGCTAGAAGTCCATATCGGCTGGCTGTTGCTCCAGGCCCCTCGGTGGGTGTTCAAGGAG GAAGACCCTATTCACCTGAGGTGTCACAGCTGGAAGAACACTGCTCTGCATAAGGTCACA TATTTACAGAATGGCAAAGACAGGAAGTATTTTCATCATAATTCTGACTTCCACATTCCA AAAGCCACACTCAAAGATAGCGGCTCCTACTTCTGCAGGGGGCTTGTTGGGAGTAAAAAT GTGTCTTCAGAGACTGTGAACATCACCATCACTCAAGGTTTGGCAGTGTCAACCATCTCA TCATTCTCTCCACCTGGGTACCAAGTCTCTTTCTGCTTGGTGATGGTACTCCTTTTTGCA GTGGACACAGGACTATATTTCTCTGTGAAGACAAACATTTGA
- Chromosome Location
- 1
- Locus
- 1q23.3
- External Identifiers
Resource Link UniProtKB ID O75015 UniProtKB Entry Name FCG3B_HUMAN GenBank Protein ID 31322 GenBank Gene ID X16863 GeneCard ID FCGR3B GenAtlas ID FCGR3B HGNC ID HGNC:3620 PDB ID(s) 1E4J, 1E4K, 1FNL, 1T83, 1T89, 6EAQ KEGG ID hsa:2215 NCBI Gene ID 2215 - General References
- Ravetch JV, Perussia B: Alternative membrane forms of Fc gamma RIII(CD16) on human natural killer cells and neutrophils. Cell type-specific expression of two genes that differ in single nucleotide substitutions. J Exp Med. 1989 Aug 1;170(2):481-97. [Article]
- Simmons D, Seed B: The Fc gamma receptor of natural killer cells is a phospholipid-linked membrane protein. Nature. 1988 Jun 9;333(6173):568-70. [Article]
- Peltz GA, Grundy HO, Lebo RV, Yssel H, Barsh GS, Moore KW: Human Fc gamma RIII: cloning, expression, and identification of the chromosomal locus of two Fc receptors for IgG. Proc Natl Acad Sci U S A. 1989 Feb;86(3):1013-7. [Article]
- Scallon BJ, Scigliano E, Freedman VH, Miedel MC, Pan YC, Unkeless JC, Kochan JP: A human immunoglobulin G receptor exists in both polypeptide-anchored and phosphatidylinositol-glycan-anchored forms. Proc Natl Acad Sci U S A. 1989 Jul;86(13):5079-83. [Article]
- Bertrand G, Duprat E, Lefranc MP, Marti J, Coste J: Characterization of human FCGR3B*02 (HNA-1b, NA2) cDNAs and IMGT standardized description of FCGR3B alleles. Tissue Antigens. 2004 Aug;64(2):119-31. [Article]
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- Gessner JE, Grussenmeyer T, Kolanus W, Schmidt RE: The human low affinity immunoglobulin G Fc receptor III-A and III-B genes. Molecular characterization of the promoter regions. J Biol Chem. 1995 Jan 20;270(3):1350-61. [Article]
- Sondermann P, Huber R, Oosthuizen V, Jacob U: The 3.2-A crystal structure of the human IgG1 Fc fragment-Fc gammaRIII complex. Nature. 2000 Jul 20;406(6793):267-73. [Article]
- Zhang Y, Boesen CC, Radaev S, Brooks AG, Fridman WH, Sautes-Fridman C, Sun PD: Crystal structure of the extracellular domain of a human Fc gamma RIII. Immunity. 2000 Sep;13(3):387-95. [Article]
- Bux J, Stein EL, Bierling P, Fromont P, Clay M, Stroncek D, Santoso S: Characterization of a new alloantigen (SH) on the human neutrophil Fc gamma receptor IIIb. Blood. 1997 Feb 1;89(3):1027-34. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Alefacept approved, investigational, withdrawn unknown target Details Cetuximab approved unknown target binder Details Etanercept approved, investigational unknown target ligand Details Human immunoglobulin G approved, investigational yes target antagonist Details Gemtuzumab ozogamicin approved, investigational unknown target Details Muromonab approved, investigational unknown target Details Alemtuzumab approved, investigational unknown target binder Details Natalizumab approved, investigational unknown target ligand Details Palivizumab approved, investigational unknown target Details Daclizumab investigational, withdrawn unknown target Details Sarilumab approved, investigational unknown target unknown Details Catumaxomab approved, investigational, withdrawn yes target agonist Details