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Mechlorethamine
go.drugbank.com/drugs/DB00888ApprovedInvestigationalA vesicant and necrotizing irritant destructive to mucous membranes, mechlorethamine is an alkylating drug. It was formerly used as a war gas. … The FDA granted marketing approval for the orphan drug Valchlor (mechlorethamine) gel on August 23, 2013 for the topical treatment of stage IA and IB mycosis fungoides-type cutaneous T-cell lymphoma (CTCL
Synonyms: β,β'-dichlorodiethyl-N-methylamine, N-methyl-bis(2-chloroethyl)amineCategories: Compounds used in a research, industrial, or household settingValdecoxib
go.drugbank.com/drugs/DB00580ApprovedWithdrawnValdecoxib was removed from the Canadian, U.S., and E.U. markets in 2005 due to concerns about a possible increased risk of heart attack and stroke.
Categories: COX-2 Inhibitors, Cytochrome P-450 SubstratesProducts: PARALGEN ® 40, PARALGEN ® 20 TABLETASMethscopolamine bromide
go.drugbank.com/drugs/DB00462ApprovedA muscarinic antagonist used to study binding characteristics of muscarinic cholinergic receptors.
Synonyms: N-methylhyoscine bromide, N-methylscopolammonium bromideDalfopristin
go.drugbank.com/drugs/DB01764ApprovedDalfopristin is a combination of two antibiotics (Dalfopristin and quinupristin) used to treat infections by staphylococci and by vancomycin-resistant Enterococcus faecium. … Dalfopristin inhibits the early phase of protein synthesis in the bacterial ribosome and quinupristin inhibits the late phase of protein synthesis.
Categories: Cytochrome P-450 CYP3A Inhibitors, Cytochrome P-450 CYP3A4 Inhibitors1-Palmitoyl-2-oleoyl-sn-glycero-3-(phospho-rac-(1-glycerol))
go.drugbank.com/drugs/DB11331ApprovedWithdrawnThe product was meant to compensate for alveolar surfactant deficiency and reduce to likelihood of alveolar collapse leading to acute respiratory collapse. … Palmitoyloleoyl-phosphatidylglycerol was a component of Surfaxin, discontinued in 2017, which acted as a surfactant [FDA Label].
Synonyms: 1-Palmitoyl-2-oleoyl-sn-glycero-3-(phospho-rac-(1-glycerol)), 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerolSalts: 1-palmitoyl-2-oleoyl-sn-glycero-3-(phospho-rac-(1-glycerol)), sodium saltCarbenicillin
go.drugbank.com/drugs/DB00578ApprovedIt is susceptible to gastric juice and penicillinase and may damage platelet function.
Synonyms: N-(2-carboxy-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)hept-6-yl)-2-phenylmalonamic acid, (2S,5R,6R)-6-{[carboxy(phenyl)acetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acidCategories: Penicillin G, Heterocyclic Compounds, 2-RingChlordiazepoxide
go.drugbank.com/drugs/DB00475ApprovedIllicitIt has also been used in the symptomatic treatment of alcohol withdrawal.
Synonyms: 7-chloro-2-methylamino-5-phenyl-3H-1,4-benzodiazepin-4-oxideMixtures: Limbitrol DSLorazepam
go.drugbank.com/drugs/DB00186ApprovedInvestigationalThe first historic FDA label approval is reported in 1985 by the company Mutual Pharm.[L5095] … Lorazepam is a short-acting and rapidly cleared benzodiazepine used commonly as a sedative and anxiolytic.
Synonyms: o-Chloroxazepam, o-ChlorooxazepamProducts: ATIVAN® 1 MG TABLETAS, LORANS 1 TABLET 1 mgLefamulin
go.drugbank.com/drugs/DB12825ApprovedA pleuromotilin is a more recently developed type of antibiotic that is derived from the fungus, Pleurotus mutilus. … Lefamulin is a pleuromutilin antibiotic used for the treatment of bacterial community-acquired pneumonia.
Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesGamolenic acid
go.drugbank.com/drugs/DB13854ApprovedWithdrawnGamolenic acid is produced minimally in the body as the delta 6-desaturase metabolite of [DB00132]. It is converted to [DB00154], a biosynthetic precursor of monoenoic prostaglandins such as PGE1. … Gamolenic acid may be found in over-the-counter dietary supplements. Gamolenic acid is also found in some fungal sources and also present naturally in the form of triglycerides [F27].
Synonyms: 18:3 (n-6), (Z,Z,Z)-6,9,12-octadecatrienoic acidMixtures: PRIM E CAPSULE, Evening Primrose Oil Cap 500mg W Vit E