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Displaying results 301 - 310 of 2828 in total
  1. Target

    Choline transporter-like protein 4

    go.drugbank.com/bio_entities/BE0002182
    TransporterHumans

    Choline transporter that plays a role in the choline-acetylcholine system and is required to the efferent innervation of hair cells in the olivocochlear bundle for the maintenance of physiological function … Also described as a thiamine pyrophosphate transporter in colon, may mediate the absorption of microbiota-generated thiamine pyrophosphate and contribute to host thiamine (vitamin B1) homeostasis (PubMed

    Polypeptides: Choline transporter-like protein 4Synonyms: Thiamine pyrophosphate transporter 1
  2. Target

    Excitatory amino acid transporter 5

    go.drugbank.com/bio_entities/BE0002267
    TargetHumans

    Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (PubMed:9108121). … Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate.

    Polypeptides: Excitatory amino acid transporter 5Synonyms: Retinal glutamate transporter
  3. Target

    Vesicular inhibitory amino acid transporter

    go.drugbank.com/bio_entities/BE0002308
    TransporterHumans

    The transport is equally dependent on the chemical and electrical components of the proton gradient (By similarity). May also transport beta-alanine (By similarity).

    Polypeptides: Vesicular inhibitory amino acid transporterSynonyms: GABA and glycine transporter, Vesicular GABA transporter
  4. Target

    Organic solute transporter subunit beta

    go.drugbank.com/bio_entities/BE0003668
    TransporterHumans

    The OST-alpha/OST-beta complex efficiently transports the major species of bile acids (taurocholate) (PubMed:16317684, PubMed:41606314, PubMed:41606328). … Essential component of the OST-alpha/OST-beta complex, a heterotetramer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood (PubMed:16317684

    Polypeptides: Organic solute transporter subunit betaFunction: bile acid transmembrane transporter activity
  5. Target

    Sodium-coupled monocarboxylate transporter 1

    go.drugbank.com/bio_entities/BE0004708
    TransporterHumans

    Acts as an electrogenic sodium (Na(+)) and chloride (Cl-)-dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D-lactate, pyruvate … Can mediate the transport of chloride, bromide, iodide and nitrate ions when the external concentration of sodium ions is reduced (PubMed:19864324). Part of D-serine transport systems.

    Polypeptides: Sodium-coupled monocarboxylate transporter 1Synonyms: Apical iodide transporter
  6. Target

    Uncharacterized MFS-type transporter EfpA

    go.drugbank.com/bio_entities/BE0009715
    TargetMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

    Polypeptides: Uncharacterized MFS-type transporter EfpAFunction: transmembrane transporter activity
  7. Target

    NPC intracellular cholesterol transporter 2

    go.drugbank.com/bio_entities/BE0010359
    TransporterHumans

    The secreted form of NCP2 regulates biliary cholesterol secretion via stimulation of ABCG5/ABCG8-mediated cholesterol transport (By similarity) … Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal compartment (PubMed:11125141, PubMed:15937921, PubMed:17018531

    Polypeptides: NPC intracellular cholesterol transporter 2
  8. Target

    Ammonium transporter Rh type B

    go.drugbank.com/bio_entities/BE0019489
    TransporterHumans

    May transport either NH4(+) or NH3 ammonia species predominantly mediating an electrogenic NH4(+) transport (PubMed:15284342, PubMed:15929723, PubMed:24077989). … Ammonium transporter involved in the maintenance of acid-base homeostasis.

    Polypeptides: Ammonium transporter Rh type B
  9. Indication

    Copper Deficiency

    go.drugbank.com/conditions/DBCOND0048480
    Drugs: Cupric sulfate
    Synonyms: Copper low, Copper Deficiency
  10. Drug

    Hepcidin-25

    go.drugbank.com/drugs/DB19226
    Investigational

    Hepcidin-25 is under investigation in clinical trial NCT03381833 (A Study With LJPC-401 for the Treatment of Myocardial Iron Overload in Patients With Transfusion-dependent Beta Thalassemia).

    Synonyms: Asp-thr-his-phe-pro-ile-cys-ile-phe-cys-cys-gly-cys-cys-his-arg-ser-lys-cys-gly-met-cys-cys-lys-thr (7->23),(10->13),(11->19),(14->22)-tetrakis(disulfide)