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Displaying results 3091 - 3100 of 10000 in total
  1. Drug

    Pamrevlumab

    go.drugbank.com/drugs/DB14952
    Investigational

    Pamrevlumab is under investigation in clinical trial NCT00913393 (Study of FibroGen (FG)-3019 in Subjects With Type 2 Diabetes Mellitus and Kidney Disease on ACEi and/or ARB Therapy).

  2. Drug

    Edaravone

    go.drugbank.com/drugs/DB12243
    ApprovedInvestigational

    [A254257] It has three tautomers. … [L44017] Edaravone was initially granted orphan designation by the European Medicines Agency on June 19, 2015 [L44007] and was under regulatory review in Europe.

    Synonyms: 3-methyl-1-phenyl-5-pyrazolone, 3-methyl-1-phenylpyrazol-5-one
  3. Drug

    Peach

    go.drugbank.com/drugs/DB10552
    Approved

    Peach allergenic extract is used in allergenic testing.

  4. Drug

    Technetium Tc-99m disofenin

    go.drugbank.com/drugs/DB09164
    ApprovedWithdrawn

    for liver uptake) as are other tracers from the iminodiacetic acid. … It is available as an intravenous injection in a preparation kit under the name Hepatolite.

  5. Drug

    Ponesimod

    go.drugbank.com/drugs/DB12016
    ApprovedInvestigational

    [A232079] Ponesimod was granted FDA approval on 18 March 2021.[L32709] … [A232079,L32709] Ponesimod was developed out of a need for a more selective modulator of sphingosine 1-phosphate receptor 1 than [fingolimod].

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Substrates
  6. Drug

    Bepridil

    go.drugbank.com/drugs/DB01244
    ApprovedWithdrawn

    It has antihypertensive and selective anti-arrhythmia activities and acts as a calmodulin antagonist. … It is no longer marketed in the United States, as it has been implicated in causing ventricular arrhythmias (ie. Torsade de pointes).

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 Inhibitors
  7. Drug

    Glycyrrhizic acid

    go.drugbank.com/drugs/DB13751
    ApprovedInvestigational

    [A33062] From January 2014, glycyrrhizic acid as part of the licorice extract was approved by the FDA as an existing food sweetener. … [T204] Glycyrrhizic acid has been developed in Japan and China as a hepatoprotective drug in cases of chronic hepatitis.

  8. Drug

    Cilomilast

    go.drugbank.com/drugs/DB03849
    Investigational

    Cilomilast (Ariflo, SB-207,499) is a drug which was developed for the treatment of respiratory disorders such as asthma and Chronic Obstructive Pulmonary Disease (COPD). … It is orally active and acts as a selective Phosphodiesterase-4 inhibitor.

  9. Drug

    rhMBL

    go.drugbank.com/drugs/DB05237
    Investigational

    Over 10 percent of the general population is estimated to be MBL-deficient. Natural MBL is a 400-700kDa oligomer made of 3 identical 32kDa peptide chains.

  10. Pathway

    Acylcarnitine (9S,10E,12S,13S)-9,12,13-trihydroxyoctadec-10-enoylcarnitine

    smpdb.ca/view/SMP0124324
    Metabolic

    (9S,10E,12S,13S)-9,12,13-trihydroxyoctadec-10-enoylcarnitine is an acylcarnitine. … In forming an acylcarnitine derivative, (9S,10E,12S,13S)-9,12,13-trihydroxyoctadec-10-enoyl-CoA reacts with L-carnitine to form (9S,10E,12S,13S)-9,12,13-trihydroxyoctadec-10-enoylcarnitine.

    Drugs: Biotin · Adenosine phosphate · ATP · Levocarnitine · Magnesium cation · Pyrophosphoric acid +1 more