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Efgartigimod alfa
go.drugbank.com/drugs/DB15270ApprovedInvestigational[A243759,A243784] Efgartigimod alfa is a first-in-class[L39501] antagonist of the neonatal Fc receptor (FcRn) used in the treatment of MG. … [A243759] The production of IgG autoantibodies against acetylcholine receptors (AChRs) is one of the more common pathophysiological mechanisms behind MG, and results in the destruction of these receptors
Categories: Human Immunoglobulin GProducts: Vyvgart ScZolpidem
go.drugbank.com/drugs/DB00425ApprovedInvestigationalZolpidem, also known as _Ambien_, is a hypnotic drug that was initially approved by the FDA in 1992 [FDA label]. Zolpidem improves sleep in patients with insomnia. … Its tolerability profile is favorable when administered according to the manufacturer’s instructions, with a low risk of drug withdrawal, drug dependence, and drug tolerance [A175426].
Synonyms: N,N,6-Trimethyl-2-(4-methylphenyl)imidazo(1,2-a)pyridine-3-acetamideMixtures: Gabazolpidem-5, Sentrazolpidem PM-5Estrone sulfate
go.drugbank.com/drugs/DB04574ApprovedIt has several uses such as: alleviate symptoms of menopause as hormone replacement therapy, treatment some types of infertility, treatment of some conditions leading to underdevelopment of female sexual … Estrone sulfate (as estropipate) is a form of estrogen.
Categories: MATE 1 Substrates, MATE 2 SubstratesSynonyms: Estrone 3-sulfate, Estrone-3-sulphateEnprofylline
go.drugbank.com/drugs/DB00824ApprovedWithdrawnEnprofylline is used in asthma, chronic obstructive pulmonary disease, and in the management of cerebrovascular insufficiency, sickle cell disease, and diabetic neuropathy. … Enprofylline is a derivative of theophylline which shares bronchodilator properties.
Categories: Heterocyclic Compounds, 2-RingSynonyms: 3-n-propylxanthine, 3-propylxanthineMezlocillin
go.drugbank.com/drugs/DB00948ApprovedIt has been proposed for infections with certain anaerobes and may be useful in inner ear, bile, and CNS infections.
Synonyms: (2S,5R,6R)-3,3-dimethyl-6-{[(2R)-2-({[3-(methylsulfonyl)-2-oxoimidazolidin-1-yl]carbonyl}amino)-2-phenylacetyl]amino}-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6β-{(2R)-2-[3-(methanesulfonyl)-2-oxoimidazolidine-1-carboxamido]-2-phenylacetamido}penicillanic acidCategories: Penicillin G, Heterocyclic Compounds, 2-RingAvelumab
go.drugbank.com/drugs/DB11945ApprovedInvestigationalAvelumab is a human IgG1 lambda monoclonal antibody that binds programmed cell death ligand-1 (PD-L1) to block its interaction with its receptors found on T cells and antigen-presenting cells. … It is used in the treatment of Merkel cell carcinoma, metastatic urothelial carcinoma, or renal cell carcinoma.
Categories: PD-1/PDL-1 (Programmed cell death protein 1/death ligand 1) inhibitors, PD-1/PD-L1 (Programmed cell death protein 1/death ligand 1) inhibitorsProducts: BAVENCIO®, BAVENCIO 200 MG/10 ML IV İNFÜZYONLUK ÇÖZELTİ HAZIRLAMAK İÇİN KONSANTRE, 1 FLAKONParamethadione
go.drugbank.com/drugs/DB00617ApprovedParamethadione is an anticonvulsant in the oxazolidinedione class. It is associated with fetal trimethadione syndrome, which is also known as paramethadione syndrome.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C8 SubstratesSuprofen
go.drugbank.com/drugs/DB00870ApprovedWithdrawnIt inhibits prostaglandin synthesis and has been proposed as an anti-arthritic. It is no longer approved for use in the United States.
Synonyms: 2-(4-(2-Thenoyl)phenyl)propionsäure, (±)-2-(p-(2-thenoyl)phenyl)propionic acidCategories: Non COX-2 selective NSAIDS, Cytochrome P-450 SubstratesNiraparib
go.drugbank.com/drugs/DB11793ApprovedInvestigational[A253248] First approved by the FDA on March 27, 2017,[A253912] niraparib is used to treat epithelial ovarian, fallopian tube, or primary peritoneal cancer. … [L43277] Niraparib was approved by the European Commission on November 16, 2017 [L43742] and by Health Canada on June 27, 2019.
Categories: MATE 1 Substrates with a Narrow Therapeutic Index, MATE 2 Substrates with a Narrow Therapeutic IndexMitomycin
go.drugbank.com/drugs/DB00305ApprovedInvestigationalTract Urothelial Cancer (LG-UTUC)[L12867] - as well as adjunctly to _ab externo_ glaucoma surgeries. … [A193419] Mitomycin's cross-linking activity has resulted in its approval for the treatment of a variety of cancers - the most recent of which is an April 2020 approval for its use in low-grade Upper
Synonyms: Mito-C, Mitocin-CCategories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 2-Ring