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Tipranavir
go.drugbank.com/drugs/DB00932ApprovedInvestigationalTipranavir is a sulfonamide-containing dyhydropyrone and a nonpeptidic protease inhibitor that targets the HIV protease. Tipranavir and ritonavir are coadministered to treat HIV.
Cyproheptadine
go.drugbank.com/drugs/DB00434ApprovedInvestigational[L32474] It is used primarily to treat allergic symptoms, though it is perhaps more notable for its use in appetite stimulation[L32519] and its off-label use in the treatment of serotonin syndrome.
Synonyms: 1-methyl-4-(5-dibenzo(a,e)cycloheptatrienylidene)piperidineCategories: Serotonin Receptor Antagonists, Serotonin 5-HT2 Receptor AntagonistsBromfenac
go.drugbank.com/drugs/DB00963ApprovedWithdrawnNon-ophthalmic formulations of bromfenac were withdrawn in the US in 1998 due to cases of severe liver toxicity.[L43942,T239] … Ophthalmic NSAIDs are becoming a cornerstone for the management of ocular pain and inflammation.
Pirtobrutinib
go.drugbank.com/drugs/DB17472ApprovedInvestigationalAlthough the mechanisms of resistance to covalent BTK inhibitors have not been fully elucidated, it appears that the presence of Cys481 mutations is the most common reason for resistance to covalent BTK … [A256758] Unlike BTK covalent inhibitors, such as [ibrutinib], that bind to the cysteine 481 (Cys481) amino acid within the active site of BTK, the inhibitory activity of pirtobrutinib is maintained even
Tioconazole
go.drugbank.com/drugs/DB01007ApprovedTioconazole interacts with 14-alpha demethylase, a cytochrome P-450 enzyme that converts lanosterol to ergosterol, an essential component of the yeast membrane. … In addition to being an antifungal, tioconazole also has antibacterial effects on certain Gram-positive cocci bacteria.[L50166]
Zomepirac
go.drugbank.com/drugs/DB04828ApprovedWithdrawnThe manufacturer voluntarily removed Zomax tablets from the Canadian, US, and UK markets in March 1983.
Ethanolamine oleate
go.drugbank.com/drugs/DB06689ApprovedIt is composed of ethanolamine, a basic substance, which when combined with oleic acid forms a clear, straw to pale yellow colored, deliquescent oleate.
Synonyms: Oleate de monoethanolamine, Oleato de monoetanolaminioVardenafil
go.drugbank.com/drugs/DB00862Approvedof cGMP in the smooth muscle cells of the corpus cavernosum. … [A258318] The FDA approved the use of vardenafil for the treatment of erectile dysfunction in 2003.
Dantrolene
go.drugbank.com/drugs/DB01219ApprovedInvestigationalChemically, dantrolene is a hydantoin derivative, but does not exhibit antiepileptic activity like other hydantoin derivates such as phenytoin.