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Vepdegestrant
go.drugbank.com/drugs/DB19006ApprovedInvestigational, such as cyclin-dependent kinase (CDK) 4/6 inhibitors. … [A275507, A275508, A275511] It was identified through a targeted medicinal chemistry optimization campaign to act as a next-generation endocrine therapy for breast cancer.
Categories: Cytochrome P-450 CYP2B6 Inhibitors, Cytochrome P-450 SubstratesSynonyms: 2,6-piperidinedione, 3-(1,3-dihydro-1-oxo-5-(4-((1-(4-((1r,2s)-1,2,3,4-tetrahydro-6-hydroxy-2-phenyl-1-naphthalenyl)phenyl)-4-piperidinyl)methyl)-1-piperazinyl)-2h-isoindol-2-yl)-, (3s)-Benzylfentanyl
go.drugbank.com/drugs/DB09182ExperimentalIllicitBenzylfentanyl has a Ki of 213nM at the mu opioid receptor, binding around 200x less strongly than fentanyl itself. … In 2010 it was removed from the list after it was found to have minimal opioid activity.
V1003
go.drugbank.com/drugs/DB05046ExperimentalBuprenorphine is a well-known analgesic and the intranasal formulation has the potential to provide a convenient alternative to other treatments, allowing patients to manage their post-operative pain both
NV-52
go.drugbank.com/drugs/DB05673ExperimentalNV-52 is an investigational synthetic flavonoid thromboxane synthase (TXS) inhibitor developed for the maintenance of remission in inflammatory bowel disease.
Z-Val-Ala-Asp fluoromethyl ketone
go.drugbank.com/drugs/DB07744ExperimentalIt does not require an esterase to hydrolyze the O-methyl ester like the cell-permeable form, Z-Val-Ala-Asp(O-Me) fluoromethyl ketone. … Non-methylated, competitive, and irreversible inhibitor of caspase 1, as well as other caspases,1 which can be used directly with purified enzymes.
CRx-119
go.drugbank.com/drugs/DB05688ExperimentalCRx-119 is a combination of a low dose of the steroid prednisolone, 3mg, and amoxapine.
CXA-10
go.drugbank.com/drugs/DB15026InvestigationalCXA-10 is under investigation in clinical trial NCT03422510 (FIRSTx - A Study of Oral CXA-10 in Primary Focal Segmental Glomerulosclerosis (FSGS)).
Synonyms: 10-nitro-9(E)-octadec-9-enoic acidMethaqualone
go.drugbank.com/drugs/DB04833ApprovedIllicitWithdrawnIt has also been used illegally as a recreational drug, commonly known as Quaaludes, Sopors, Ludes or Mandrax (particularly in the 1970s in North America) depending on the manufacturer. … The sedative-hypnotic activity was first noted by Indian researchers in the 1950s and in 1962 methaqualone itself was patented in the US by Wallace and Tiernan.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesInfluenza B virus B/Maryland/15/2016 BX-69A antigen (formaldehyde inactivated)
go.drugbank.com/drugs/DB14559ApprovedInvestigationalthat it was previously exposed to. … Inactivated vaccines contain a virus particle that has been grown in media and then subsequently killed, or inactivated, through exposure to heat or chemicals such as formaldehyde 3.
Mixtures: VAXİGRİP 0,5 ML IM/SC ENJEKSİYON İÇİN SÜSPANSİYON İÇEREN KULLANIMA HAZIR ENJEKTÖR , 10 ADET, VAXİGRİP TETRA 0,5 ML IM/SC ENJEKSİYON İÇİN SÜSPANSİYON İÇEREN KULLANIMA HAZIR ENJEKTÖR , 1 ADETFostamatinib
go.drugbank.com/drugs/DB12010ApprovedInvestigationalIt was approved on April 17, 2018, under the trade name Tavalisse for use in ITP [L2644, L52150]. Fostamatinib has also been granted orphan drug status by the FDA [L2644]. … Recently, fostamatinib has been identified as a potential therapeutic for controlling acute respiratory distress syndrome (ARDS) in patients with severe COVID-19 through its ability to modulate the SYK
Categories: Phosphodiesterase 5 Inhibitors, Cytochrome P-450 Substrates