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Stroke
go.drugbank.com/conditions/DBCOND0020609Drugs: Acetylsalicylic acid · Alirocumab · Apixaban · Atorvastatin · Cerebrolysin · Choline alfoscerate +14 moreSynonyms: Stroke and cerebrovascular accident unspecified, Stroke and cerebrovascular accident unspecified (disorder)Bepotastine
go.drugbank.com/drugs/DB04890ApprovedBepotastine was approved in Japan for use in the treatment of allergic rhinitis and uriticaria/puritus in July 2000 and January 2002, respectively, and is marketed by Tanabe Seiyaku Co., Ltd. under the … It is available in oral and opthalmic dosage forms in Japan. The opthalmic solution is FDA approved since Sept 8, 2009 and is under the brand name Bepreve.
Velmanase alfa
go.drugbank.com/drugs/DB12374ApprovedInvestigationalThe resulting accumulation of sugars in the body leads to an array of clinical manifestations leading to progressive neuromuscular and skeletal deterioration, such as skeletal abnormalities, motor function … Patients with alpha-mannosidosis have a genetic mutation that causes a deficiency in the lysosomal enzyme alpha-mannosidase, which is an enzyme responsible for breaking down complex sugars in the body.
Categories: Enzymes and Coenzymes, Alimentary Tract and MetabolismAttention Deficit Hyperactivity Disorder (ADHD)
go.drugbank.com/conditions/DBCOND0041782Synonyms: Attention Deficit and Hyperactivity Disorders, Attention-Deficit and Hyperactivity DisorderVoretigene neparvovec
go.drugbank.com/drugs/DB13932ApprovedInvestigationalWhen used in genetic therapy, this virus is modified for the elimination of its negligible integrative capacity by the removal of *rep* and *cap* and the insertion of the desired gene with its promoter … [A31478] VN-rzyl was developed by Spark Therapeutics Inc. and FDA approved on December 19, 2017.[L1095]
Synonyms: VN-rzylHomatropine
go.drugbank.com/drugs/DB11181ApprovedHomatropine is an anticholinergic drug that acts as an antagonist at muscarinic acetylcholine receptors. … use has not been approved by the FDA to be safe and effective.
Categories: Mydriatics and CycloplegicsPlant-based virus-like particles, recombinant, adjuvanted COVID-19 vaccine
go.drugbank.com/drugs/DB16757ApprovedThe Covifenz COVID-19 vaccine (plant-based virus-like particles (VLP), recombinant, adjuvanted) is a plant-based vaccine developed in partnership by Medicago and GlaxoSmithKline which is approved in Canada … [L40694] It is composed of VLPs expressing SARS-CoV-2 spike protein trimers (stabilized in a pre-fusion conformation) and is mixed with the AS03 adjuvant system prior to administration.
Technetium Tc-99m mebrofenin
go.drugbank.com/drugs/DB09137ApprovedWithdrawnMore specifically, mebrofenin is taken up into hepatocytes through the action of OATP1B1 and OATP1B3 transporters. … Liver and gallbladder imaging is enabled through attachment to mebrofenin as this molecule has high hepatic uptake and fast biliary excretion, resulting in improved hepatic imaging.
Categories: Compounds used in a research, industrial, or household setting, Indicators and ReagentsTranscription factor p65
go.drugbank.com/bio_entities/BE0005551TargetHumansThe dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity … NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family.
Synonyms: Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3Serine/threonine-protein kinase Nek1
go.drugbank.com/bio_entities/BE0009496TargetHumansPhosphorylates serines and threonines, but also appears to possess tyrosine kinase activity (PubMed:20230784). … Involved in DNA damage checkpoint control and for proper DNA damage repair (PubMed:20230784).
Synonyms: Never in mitosis A-related kinase 1