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Rotavirus vaccine
go.drugbank.com/drugs/DB10276ApprovedInvestigationalRotateq is a live vaccine consisting of 5 reassorted human-bovine viral strains.[L1116] Rotarix is a live attenuated vaccine containing the 89-12 human strain.
Salts: Human Rotavirus A type G1P(8) strain RIX4414 live antigen, Human Rotavirus A type G1P7(5) strain WI79 live antigenCategories: Complex MixturesDihydrolipoyl dehydrogenase
go.drugbank.com/bio_entities/BE0002616TargetPseudomonas putidaThe branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2).
Synonyms: E3 component of branched-chain alpha-keto acid dehydrogenase complexPalifermin
go.drugbank.com/drugs/DB00039ApprovedInvestigationalPalifermin is a recombinant human keratinocyte growth factor (KGF). It is 140 residues long, and is produced using E. coli. Palifermin was granted FDA approval on 15 December 2004.[L17933]
Ponatinib
go.drugbank.com/drugs/DB08901ApprovedInvestigationalPonatinib is a novel Bcr-Abl tyrosine kinase inhibitor that is especially effective against the T315I mutation for the treatment of chronic myeloid leukemia. FDA approved on December 14, 2012.
Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP2C8 Substrates with a Narrow Therapeutic IndexSonidegib
go.drugbank.com/drugs/DB09143ApprovedInvestigationalSonidegib is a Hedgehog signaling pathway inhibitor (via smoothened antagonism) developed as an anticancer agent by Novartis. It was FDA approved in 2015 for the treatment of basal cell carcinoma.
Categories: Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic IndexCoal tar
go.drugbank.com/drugs/DB11082ApprovedCoal tar is a brown or black liquid of extremely high viscosity. Coal tar is among the by-products when coal is carbonized to make coke or gasified to make coal gas. … Coal tars are complex and variable mixtures of phenols, polycyclic aromatic hydrocarbons (PAHs), and heterocyclic compounds.
Mixtures: Medi-dan Shampoo, Targel SaCategories: Complex MixturesPentetrazol
go.drugbank.com/drugs/DB13415ApprovedWithdrawnPentetrazol, also known as pentylenetetrazole, is a gamma-aminobutyric acid type A (GABA<sub>A</sub>) receptor antagonist that was approved by the FDA until 1982.[A254437]
Phosphoric acid
go.drugbank.com/drugs/DB09394ApprovedInvestigationalPhosphoric Acid is a colorless, odorless phosphorus-containing inorganic acid. Phosphoric acid is a sequestering agent which binds many divalent cations, including Fe++, Cu++, Ca++, and Mg++.
Categories: Compounds used in a research, industrial, or household settingErlotinib
go.drugbank.com/drugs/DB00530ApprovedInvestigationalRecent studies demonstrate that erlotinib is also a potent inhibitor of JAK2V617F, which is a mutant form of tyrosine kinase JAK2 found in most patients with polycythemia vera (PV) and a substantial proportion … Erlotinib binds to the epidermal growth factor receptor (EGFR) tyrosine kinase in a reversible fashion at the adenosine triphosphate (ATP) binding site of the receptor.
Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic IndexGuanfacine
go.drugbank.com/drugs/DB01018ApprovedInvestigational[A189841] Guanfacine was granted FDA approval on 27 October 1986.[L11274] … Guanfacine, or BS 100-141,[A189838,A189841] is a selective alpha-A2 adrenergic receptor agonist initially indicated for the treatment of hypertension[L11274] but is now indicated as an extended release