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Mechlorethamine
go.drugbank.com/drugs/DB00888ApprovedInvestigationalA vesicant and necrotizing irritant destructive to mucous membranes, mechlorethamine is an alkylating drug. It was formerly used as a war gas. The hydrochloride is used as an antineoplastic in Hodgkin's disease and lymphomas. It causes s...
Synonyms: methylbis(2-chloroethyl)amine, methylbis(β-chloroethyl)amineEzetimibe
go.drugbank.com/drugs/DB00973ApprovedInvestigational[A15202] By interfering with the intestinal uptake of cholesterol and phytosterols, ezetimibe reduces the delivery of intestinal cholesterol to the liver.[L11347] … Unlike other classes of cholesterol-reducing compounds including statins and bile acid sequestrants, ezetimibe has a distinct mechanism of action involving the sterol transporter Niemann-Pick C1-Like 1
Mixtures: LIPIVAN E ® 10 MG / 10 MG, SimEz 10 mg/10 mg TablettenCategories: Heterocyclic Compounds, 1-RingGadodiamide
go.drugbank.com/drugs/DB00225ApprovedInvestigational[A263096] Approved by the FDA in 1993, gadodiamide is the first non-ionic GBCA to be used. … [A263086,A263091] GBCAs constitute the largest group of MR agents, and they are thought to be safer than nonionic iodinated contrast agents.
Products: SCANIX 287 MG/ML IV ENJEKSİYONİÇİN ÇÖZELTİ İÇEREN FLAKON, 10 ML, GADOTU 287 MG/ML IV ENJEKSIYON IÇIN ÇÖZELTI IÇEREN FLAKON ,10 MLLeflunomide
go.drugbank.com/drugs/DB01097ApprovedInvestigationalLeflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999.
Categories: Heterocyclic Compounds, 1-RingProducts: ARAVA 10 MG FTA, LEFLUNOMID ARISTO 10 MGAmlodipine
go.drugbank.com/drugs/DB00381ApprovedInvestigationalAmlodipine, initially approved by the FDA in 1987, is a popular antihypertensive drug belonging to the group of drugs called _dihydropyridine calcium channel blockers_.
Mixtures: COVERAM 10 MG/10 MG, Triveram 20 mg/10 mg/10 mg FilmtablettenCategories: Heterocyclic Compounds, 1-RingVortioxetine
go.drugbank.com/drugs/DB09068ApprovedInvestigationalSome serotonin receptors seem to play a relatively neutral or insignificant role in the regulation of mood, but others, such as 5-HT1A autoreceptors and 5-HT7 receptors, appear to play an oppositional
Categories: Heterocyclic Compounds, 1-RingProducts: BRINTELLIX® 10 MG, BRINTELLIX 10 MG FILM KAPLI TABLET ,56 TABLETGalantamine
go.drugbank.com/drugs/DB00674ApprovedInvestigational[A182993] The drug was approved by the FDA in 2001 for the treatment of mild to moderate dementia of the Alzheimer's type.
Mixtures: GALNORA 8MG + 16MG HKP RET, GALNORA 8MG + 16MG HKP RETProducts: ANTAMIN ® 16 MG, Margal 16 mg RetardkapselnPravastatin
go.drugbank.com/drugs/DB00175ApprovedInvestigational[T274] This drug was developed by Sankyo Co. Ltd.; however, the first approved pravastatin product was developed by Bristol Myers Squibb and FDA approved in 1991. … The manufacturing process is followed by the hydrolysis of the lactone group and the biological hydroxylation with _Streptomyces carbophilus_ to introduce the allylic 6-alcohol group.[T239]
Synonyms: (+)-(3R,5R)-3,5-dihydroxy-7-[(1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-{[(S)-2-methylbutyryl]oxy}-1,2,6,7,8,8a-hexahydro-1-naphthyl]heptanoic acidProducts: AFAP 10 MG, PAVAS 10 MG TABLET, 100 ADETAtorvastatin
go.drugbank.com/drugs/DB01076ApprovedInvestigational[A181087, A181406] Some evidence has shown that even for low-risk individuals (with <10% risk of a major vascular event occurring within five years) statin use leads to a 20%-22% relative reduction in … [A181397, A181403] Atorvastatin was first synthesized in 1985 by Dr. Bruce Roth and approved by the FDA in 1996.
Mixtures: Triveram 20 mg/10 mg/10 mg Filmtabletten, Triveram 40 mg/10 mg/10 mg FilmtablettenCategories: Heterocyclic Compounds, 1-RingIrinotecan
go.drugbank.com/drugs/DB00762ApprovedInvestigational[A263376] Approved by the FDA in 1996,[A263366] irinotecan is used to treat colorectal cancer and pancreatic adenocarcinoma. … Both irinotecan and SN-38 mediate antitumor activity by forming a complex with topoisomerase I and blocking its enzymatic activity, thereby interfering with DNA synthesis.
Synonyms: )ethyl)piperidine-1-carboxylate, (S)-4,11-diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl 4-(2-(5-(3-(2,4-dihydroxy-5-isopropylphenyl)-5-hydroxy-4H-1,2,4-triazol-4-yl)-1H-indol-1-ylCategories: Topoisomerase 1 (TOP1) inhibitors