Search
Mitotane
go.drugbank.com/drugs/DB00648ApprovedInvestigationalMitotane is an adrenolytic isomer of the insecticide dichlorodiphenyldichloroethane (DDD) - itself a metabolite of dichlorodiphenyltrichloroethane (DDT) - that inhibits cells of the adrenal cortex and … It has been in use since 1959 for the treatment of inoperable adrenocortical carcinoma[A263010] and is used off-label for the management of Cushing's syndrome.[A263016]
Bavituximab
go.drugbank.com/drugs/DB05136InvestigationalBavituximab is a chimeric Anti-PS monoclonal antibody analog which is used to potentially treat cancers and viral infections. … It binds to phosphatidylserine and other exposed host cell lipids when induced by cellular stress. Additional analogs in the class include 3G4, 2aG4, 9d2 and Hu3g4.
Fostamatinib
go.drugbank.com/drugs/DB12010ApprovedInvestigationalIt was approved on April 17, 2018, under the trade name Tavalisse for use in ITP [L2644, L52150]. Fostamatinib has also been granted orphan drug status by the FDA [L2644]. … Recently, fostamatinib has been identified as a potential therapeutic for controlling acute respiratory distress syndrome (ARDS) in patients with severe COVID-19 through its ability to modulate the SYK
Benzonatate
go.drugbank.com/drugs/DB00868ApprovedBenzonatate is an oral antitussive drug used in the relief and suppression of cough in patients older than ten years of age. … [L11193] Although it not prone to drug misuse or abuse, benzonatate is associated with a risk for severe toxicity and overdose, especially in children.[A189513]
Categories: Decreased Tracheobronchial Stretch Receptor ActivitySomatrogon
go.drugbank.com/drugs/DB14960ApprovedInvestigational[L39362] In October 2021, Health Canada approved somatrogon under the market name NGENLA as the long-term treatment of pediatric patients who have growth failure due to an inadequate secretion of endogenous … Growth hormone is a peptide hormone secreted by the pituitary gland that plays a crucial role in promoting longitudinal growth during childhood and adolescence and regulating metabolic function in adulthood
Aprocitentan
go.drugbank.com/drugs/DB15059ApprovedInvestigationalAprocitentan is a dual antagonist of endothelin receptors A and B used for treatment-resistant hypertension. It is the active metabolite of [macitentan]. … [A263386] Patients with resistant hypertension are at an increased risk of cardiovascular and renal events[A263386] and have traditionally had limited additional treatment options.
Categories: Endothelin Receptor AntagonistsIsotretinoin
go.drugbank.com/drugs/DB00982ApprovedInvestigational[L6574] Isotretinoin is associated with major risks in pregnancy and is therefore only available under the iPLEDGE program in the United States. … Isotretinoin is a retinoid derivative of vitamin A used in the treatment of severe recalcitrant acne.
Categories: Retinoids for Topical Use in AcneProducts: Ran-isotretinoinCeftobiprole medocaril
go.drugbank.com/drugs/DB14733Approved[L50467] It received its first approval in Canada in October 2017 for use in certain patients with bacterial pneumonia,[L50472] and was subsequently approved in the United States with additional indications … for skin and skin structure infections and bacteremia in April 2024.
Agmatine
go.drugbank.com/drugs/DB08838ExperimentalUp to now (July 2013), the results of this study have not yet been published. … Agmatine is both an experimental and investigational drug.
Categories: NMDA Receptor AntagonistsPolihexanide
go.drugbank.com/drugs/DB12277ApprovedInvestigational[A1351,A273908] Polihexanide is approved in Europe under the name Akantior for the treatment of _Acanthamoeba_ keratitis, an ocular infection caused by the _Acanthamoeba_ parasite. … [A1351] It is effective against a wide range of Gram-positive and Gram-negative bacteria.
Categories: Compounds used in a research, industrial, or household setting