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Displaying results 3281 - 3290 of 10000 in total
  1. Indication

    Myelofibroses

    go.drugbank.com/conditions/DBCOND0092673
    Drugs: Fedratinib · Oxymetholone · Ruxolitinib
    Synonyms: Myelofibrosis due to another disorder (disorder)
  2. Indication

    Pneumonia, Pneumocystis Jerovici

    go.drugbank.com/conditions/DBCOND0070467
    Drugs: Atovaquone · Clindamycin · Fluorescein · Pentamidine · Prednisolone · Prednisone +4 more
    Synonyms: Pneumonia due to Pneumocystis carinii
  3. Drug

    Arbutamine

    go.drugbank.com/drugs/DB01102
    Approved

    Arbutamine, administered through a closed-loop, computer-controlled drug-delivery system, is indicated to elicit acute cardiovascular responses, similar to those produced by exercise, in order to aid in

  4. Drug

    Moxidectin

    go.drugbank.com/drugs/DB11431
    ApprovedInvestigationalVet approved

    Due to these modifications, moxidectin is classified as a second generation macrocyclic lactone. … It was first used in cattle followed by an approved use in general animals. It is a semi-synthetic methoxine derivative of nemadectin which is a 16-member pentacyclic lactone of the milbemycin class.

  5. Target

    Galectin-10

    go.drugbank.com/bio_entities/BE0001886
    TargetHumans

    Regulates immune responses through the recognition of cell-surface glycans. Essential for the anergy and suppressive function of CD25-positive regulatory T-cells (Treg)

    Polypeptides: Galectin-10Synonyms: Gal-10
  6. Target

    Frizzled-10

    go.drugbank.com/bio_entities/BE0020969
    TargetHumans

    Both pathways seem to involve interactions with G proteins. … pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase.

    Polypeptides: Frizzled-10Synonyms: Fz-10
  7. Drug

    Polysilicone-15

    go.drugbank.com/drugs/DB11271
    Approved

    It is the first polymeric UVB filer consisting of chromophores attached to a silicone backbone [L2796, L2797, L2799, F87, F88, F89]. … The compound is a colorless to pale yellow viscous liquid which is soluble in organic solvents of medium polarity and insoluble in water [L2796, L2797, L2799, F87, F88, F89].

  8. Drug

    Pafolacianine

    go.drugbank.com/drugs/DB15413
    ApprovedInvestigational

    Pafolacianine, or OTL38, is a folate analogue conjugated with a fluorescent dye that absorbs light in the near-infrared (NIR) spectrum [A242572] within a range of 760 nm to 785 nm, with a peak absorption … It emits fluorescence within a range of 790 nm to 815 nm with a peak emission of 796 nm.

  9. Drug

    Tegafur-uracil

    go.drugbank.com/drugs/DB09327
    Approved

    It was developed as an anti-cancer therapy by Taiho Pharmaceutical Co Ltd.[A32073] It is approved in different countries but it is not yet approved by the FDA, Health Canada or EMA. … Tegafur-uracil is an anti-tumor compound containing tegafur (1-(2-tetrahydrofuryl)-5-fluorouracil) and uracil in a molar ratio of 1:4.

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2A6 Substrates
  10. Target

    Interleukin-10

    go.drugbank.com/bio_entities/BE0002484
    TargetHumans

    Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3 (PubMed:16982608). … In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators (PubMed:18025162).

    Polypeptides: Interleukin-10Synonyms: IL-10