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Bazedoxifene
go.drugbank.com/drugs/DB06401ApprovedInvestigationalIn 2013, the combination product containing conjugated estrogens and bazedoxifene was approved by the FDA for the treatment of moderate to severe vasomotor symptoms associated with menopause, as well as … Bazedoxifene is a third generation selective estrogen receptor modulator (SERM), developed by Pfizer following the completion of their takeover of Wyeth Pharmaceuticals.
Methysergide
go.drugbank.com/drugs/DB00247ApprovedWithdrawnMethysergide is used prophylactically in migraine and other vascular headaches and to antagonize serotonin in the carcinoid syndrome. … It antagonizes the effects of serotonin in blood vessels and gastrointestinal smooth muscle, but has few of the properties of other ergot alkaloids.
Synonyms: (+)-N-(1-(Hydroxymethyl)propyl)-1-methyl-D-lysergamide, N-(1-(Hydroxymethyl)propyl)-1-methyl-dextro-(+)-lysergamideDavunetide
go.drugbank.com/drugs/DB12613InvestigationalDavunetide is the first drug to improve memory performance by impacting the mechanisms that lead to physical damage in the brain caused by neurofibrillary tangles, one of the two established pathological … Davunetide is derived from a naturally occurring neuroprotective brain protein known as activity dependent neuroprotective protein.
Protirelin
go.drugbank.com/drugs/DB09421ApprovedIt is a tri-peptide tropic hormone, released by the hypothalamus, that stimulates the release of Thyroid Stimulating Hormone (TSH) and prolactin from the anterior pituitary. … Although not currently available in any FDA-approved product, protirelin is a component of the TRH Test where it is used to test the response of the anterior pituitary gland in conditions such as secondary
Mitotane
go.drugbank.com/drugs/DB00648ApprovedInvestigationalMitotane is an adrenolytic isomer of the insecticide dichlorodiphenyldichloroethane (DDD) - itself a metabolite of dichlorodiphenyltrichloroethane (DDT) - that inhibits cells of the adrenal cortex and their production of hormones. It has...
Synonyms: o,p'-DDDMethylchloroisothiazolinone
go.drugbank.com/drugs/DB14197ApprovedSensitivity to Methylchloroisothiazolinone may be identified with a clinical patch test. … It is also a known dermatological sensitizer and allergen; some of its side effects include flaky or scaly skin, breakouts, redness or itchiness, and moderate to severe swelling in the eye area.
Synonyms: 5-Chloro-N-methylisothiazolin-3-oneFlufenamic acid
go.drugbank.com/drugs/DB02266ApprovedIt is used in musculoskeletal and joint disorders and administered by mouth and topically. (From Martindale, The Extra Pharmacopoeia, 30th ed, p16)
Pantethine
go.drugbank.com/drugs/DB11190ApprovedIt consists of two molecules of pantetheine that form a dimer via disufide linkages, and acts as an intermediate in the production of Coenzyme A. … Pantethine is a naturally occurring compound synthesized in the body from pantothenic acid (vitamin B5) via addition of cysteamine.
Synonyms: D-Bis(N-pantothenyl-beta-aminoethyl) disulfideIloperidone
go.drugbank.com/drugs/DB04946ApprovedInvestigational[A263547] Iloperidone is currently used to treat schizophrenia and manic or mixed episodes associated with bipolar disorder.[L50527] … Iloperidone is a benzisoxazole [A263557] and an atypical antipsychotic agent that was first approved by the FDA on May 6, 2009.
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeConcizumab
go.drugbank.com/drugs/DB12820ApprovedInvestigationalConcizumab therefore provides an important treatment option for patients who have developed inhibitors to standard clotting factor replacement therapy. … [L51998,L52043] In July 2025, its indication was expanded to include all patients with hemophilia A or B, regardless of the presence of inhibitors.[L53653]