Protirelin

DB09421ApprovedSmall molecule

Protirelin is a synthetic analogue of thyrotropin-releasing hormone that has been used during diagnostic tests to evaluate function of the thyroid gland. It is a tri-peptide tropic hormone, released by the hypothalamus, that stimulates the release of Thyroid Stimulating Hormone (TSH) and prolactin from the anterior pituitary.

Chemical structure of Protirelin
Mechanism
Curator reviewed
Formula / weight
C16H22N6O4 · 362.3837 g/mol (avg)
First approval
Canada, 2004
Also known as
Thyroliberin · Thyrotropic releasing hormone · Thyrotropic-releasing factor · Thyrotropin releasing hormone · Thyrotropin-releasing factor
Code names
A-38579

Resolves to

Compound
UNII5Y5F15120WCAS24305-27-9ChEMBLCHEMBL1472ChEBI35940PubChem638678KEGGD00176
Clinical / RWD
RxNorm10580ATCV04CJ02
Structure
InChIKeyXNSAINXGIQZQOO-SRVKXCTJSA-NSMILES[H][C@@](CC1=CN=CN1)(NC(=O)[C@]1([H])CCC(=O)N1)C(=O)N1CCC[C@@]1([H])C(N)=O
Targets
P34981TRHR

What you can answer from here — as of September 30, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action
Listed above
200Drug interactionsStructured to mechanism, not free text
Sign in
6Clinical trialsPhase, status and sponsor resolved per trial
Sign in
1Structured indicationCondition, population, route and combination as fields, not prose
Sign in
5Marketed productsAcross 3 countries and 5 labellers
Sign in
1ATC codeIncluding every combination product, plus 15 drug categories
Sign in
2+ReferencesStructured and connected to the statements they support
Sign in

Which drugs share a target with Protirelin, and which of those have an active Phase 3 trial?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In