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Lisocabtagene maraleucel
go.drugbank.com/drugs/DB16582ApprovedInvestigationalLisocabtagene maraleucel is a chimeric antigen receptor (CAR) T-cell therapy, similar to [brexucabtagene autoleucel] and [axicabtagene ciloleucel]. … [A228493] Despite the adverse reactions, the majority of patients given lisocabtagene maraleucel reported an overall increase in quality of life over a 1 year period.
Categories: Antineoplastic cell and gene therapy, Antineoplastic and Immunomodulating AgentsAncrod
go.drugbank.com/drugs/DB05099ApprovedWithdrawnCurrently, Viprinex®/ancrod is not approved or marketed in any country, but is being investigated as a stroke treatment in worldwide clinical trials. In January 2005, the U.S. … Ancrod, marketed as Viprinex, is a defibrinogenating agent derived from Malayan pit viper venom. The defribrinogenation of blood results in an anticoagulant effect.
Categories: Enzymes and Coenzymes, Blood and Blood Forming OrgansCystine
go.drugbank.com/drugs/DB00138ApprovedInvestigationalNutraceuticalWithdrawnA covalently linked dimeric nonessential amino acid formed by the oxidation of cysteine. Two molecules of cysteine are joined together by a disulfide bridge to form cystine.
Categories: Amino Acids, Peptides, and ProteinsAvacopan
go.drugbank.com/drugs/DB15011ApprovedInvestigational[A240254, A240259, A240264, A240269] Avacopan (formerly CCX168) is an allosteric C5aR antagonist indicated for use in AAV. … by the presence of ANCAs in the serum.
Categories: Antineoplastic and Immunomodulating AgentsEvinacumab
go.drugbank.com/drugs/DB15354ApprovedInvestigational[L31838] In September and December 2023, evinacumab was also approved by Health Canada and EMA, respectively, for the same indication.[L49956,L49966] … Evinacumab is novel in its mechanism of action compared with other lipid-lowering therapies and therefore provides a unique and synergistic therapeutic option in the treatment of HoFH.
Categories: Amino Acids, Peptides, and ProteinsMyelodysplastic Syndrome
go.drugbank.com/conditions/DBCOND0028333Synonyms: Classical Lissencephalies and Subcortical Band Heterotopias, (Neoplasm of uncert behav of other lymphat and haematopoietic tissue) or (neoplasm of uncert behav of blood) or (idiopathic thrombocythaemia) or (megakaryocytic myelosclerosis) or (myelodysplasia)Pregnancy Toxemias
go.drugbank.com/conditions/DBCOND0027911Synonyms: EPH - Edema, proteinuria and hypertension of pregnancy, EPH - Oedema, proteinuria and hypertension of pregnancyGlasdegib
go.drugbank.com/drugs/DB11978ApprovedInvestigational[A40310] Glasdegib was developed by Pfizer Inc and approved on November 21, 2018 by the FDA for the treatment of Acute Myeloid Leukemia (AML). … [L11935] Glasdegib targets cancerous cells by inhibiting the sonic hedgehog receptor smoothened (SMO), a transmembrane protein involved in the Hedgehog (Hh) signaling cascade.
Categories: Antineoplastic and Immunomodulating AgentsEncainide
go.drugbank.com/drugs/DB01228ApprovedWithdrawnThe manufacturer of Enkaid capsules voluntarily withdrew the product from the US market on December 16, 1991. … Encainide hydrochloride, formerly marketed as Enkaid capsules, was associated with increased death rates in patients who had asymptomatic heart rhythm abnormalities after a recent heart attack.
Synonyms: (±)-4-methoxy-N-(2-(2-(1-methyl-2-piperidinyl)ethyl)phenyl)benzamide, 4-Methoxy-N-{2-[2-(1-methyl-piperidin-2-yl)-ethyl]-phenyl}-benzamideCategories: Antiarrhythmics, Class I, Antiarrhythmics, Class IcIsopropyl myristate
go.drugbank.com/drugs/DB13966ApprovedIsopropyl myristate is a moisturizer with polar characteristics used in cosmetics and topical medical preparations to ameliorate the skin absorption. … Isopropyl myristate has been largely studied and impulsed as a skin penetration enhancer.
Categories: Scabicides and Pediculicides