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Displaying results 3351 - 3360 of 10000 in total
  1. Drug

    Lesinurad

    go.drugbank.com/drugs/DB11560
    ApprovedWithdrawn

    It reduces serum uric acid concentration through the inhibition of URAT1, an enzyme responsible for reuptake of uric acid from the renal tubule, and OAT4, another uric acid transporter associated with … Lesinurad is an oral uric acid transporter 1 (URAT1) inhibitor indicated for the treatment of hyperuricemia associated with gout.

  2. Target

    Protein O-GlcNAcase

    go.drugbank.com/bio_entities/BE0005827
    TargetHumans

    Cleaves GlcNAc but not GalNAc from O-glycosylated proteins (PubMed:11148210, PubMed:11788610, PubMed:20673219, PubMed:22365600, PubMed:24088714, PubMed:28939839, PubMed:37962578). … Can use p-nitrophenyl-beta-GlcNAc and 4-methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro) (PubMed:20673219).

    Synonyms: Nuclear cytoplasmic O-GlcNAcase and acetyltransferase
  3. Indication

    Abnormal Uterine Bleeding

    go.drugbank.com/conditions/DBCOND0039070
    Drugs: Conjugated estrogens · Ethynodiol diacetate · Medroxyprogesterone acetate · Mestranol · Norgestrel · Progesterone
    Synonyms: Excessive and frequent menstruation with irregular cycle
  4. Drug

    Sitaxentan

    go.drugbank.com/drugs/DB06268
    ApprovedWithdrawn

    In 2010, Pfizer voluntarily removed sitaxentan from the market over concerns of hepatotoxicity. … Sitaxentan was marketed under the trade name Thelin for the treatment of pulmonary arterial hypertension (PAH) by Encysive Pharmaceuticals until Pfizer purchased Encysive in February 2008.

  5. Drug

    Poliovirus type 1 antigen (formaldehyde inactivated)

    go.drugbank.com/drugs/DB10795
    ApprovedInvestigational

    The vaccine contains purified and inactivated poliovirus type 1 that were grown from a continuous line of monkey kidney cells. … caused by poliovirus Type 1.

    Mixtures: Infanrix-IPV+Hib Pulver und Suspension zur Herstellung einer Injektionssuspension
  6. Drug

    Poliovirus type 3 antigen (formaldehyde inactivated)

    go.drugbank.com/drugs/DB10797
    ApprovedInvestigational

    The vaccine contains purified and inactivated poliovirus type 3 that were grown from a continuous line of monkey kidney cells. … caused by poliovirus Type 3.

    Mixtures: Infanrix-IPV+Hib Pulver und Suspension zur Herstellung einer Injektionssuspension
  7. Drug

    Sulfacetamide

    go.drugbank.com/drugs/DB00634
    Approved

    An anti-infective agent that is used topically to treat skin infections and orally for urinary tract infections.

    Mixtures: Sodium Sulfacetamide and Sulfur 10 Percent and 5 Percent Cleanser, Sodium Sulfacetamide and Sulfur 10 Percent and 2 Percent CleanserCategories: Genito Urinary System and Sex Hormones, Gynecological Antiinfectives and Antiseptics
  8. Drug

    Pegvorhyaluronidase alfa

    go.drugbank.com/drugs/DB14912
    Investigational

    Pegvorhyaluronidase alfa is under investigation in clinical trial NCT02241187 (Two Stage Study Of Single Dose PEGPH20 And Cetuximab In Patients With Pancreatic Adenocarcinoma Prior To Surgical Resection

    Synonyms: HYALURONOGLUCOSAMINIDASE PH-20, SPERM ADHESION MOLECULE 1, EC 3.2.1.35) PRECURSOR-(36-482)-PEPTIDE (MATURE (1-447)-PEPTIDE), PRODUCED IN CHINESE HAMSTER OVARY (CHO) CELLS, GLYCOFORM ALFA, SUBSTITUTED ON N6 OF ANCategories: Enzymes and Coenzymes
  9. Drug

    Difluprednate

    go.drugbank.com/drugs/DB06781
    ApprovedInvestigational

    Difluprednate is a topical corticosteroid indicated for the treatment of infammation and pain associated with ocular surgery. It is a butyrate ester of 6(α), 9(α)-difluoro prednisolone acetate.

    Categories: Hormones, Hormone Substitutes, and Hormone Antagonists
  10. Drug

    Teniposide

    go.drugbank.com/drugs/DB00444
    ApprovedInvestigational

    Accumulated breaks in DNA prevent cells from entering into the mitotic phase of the cell cycle, and lead to cell death. Teniposide acts primarily in the G2 and S phases of the cycle. … Teniposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding.

    Categories: Antineoplastic and Immunomodulating Agents