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Telisotuzumab vedotin

Telisotuzumab vedotin is an antibody-drug conjugate comprising [telisotuzumab], a c-Met-directed humanized IgG1κ monoclonal antibody, conjugated to monomethyl auristatin E (MMAE), a small molecule microtubule-disrupting … [L53158] The c-Met protein is found to be overexpressed in approximately 25% of advanced EGFR wild type, non-squamous NSCLC patients and is associated with poor prognosis and limited treatment options.

Dimethyl sulfone

Mitiglinide

Mitiglinide is a drug for the treatment of type 2 diabetes. It may stimulate insulin secretion in beta-cells by closing off ATP dependant potassium ion channels.

Chymotrypsin

It is a serine protease synthesized in the pancreas and is a vital component in the pancreatic juice. … Chymotrypsin (EC 3.4.21.1) is a digestive enzyme that promotes proteolysis, or the breakdown of proteins and polypeptides.

Chloramphenicol succinate

Chloramphenicol succinate is an ester prodrug of [chloramphenicol].[A192987] Chloramphenicol is a bacteriostatic antibiotic. … [L14174] Chloramphenicol succinate was granted FDA approval on 20 February 1959.[L12711]

Canertinib

Canertinib is a pan-erbB tyrosine kinase inhibitor which work against esophageal squamous cell carcinoma in vitro and in vivo.

Piperaquine

Eurartesim was first authorized for market by the European Medicines Agency in October 2011. … Piperaquine is an antimalarial agent first synthesized in the 1960's and used throughout China [A31550].

Masoprocol

The compound also inhibits formyltetrahydrofolate synthetase, carboxylesterase, and cyclooxygenase to a lesser extent. It also serves as an antioxidant in fats and oils. [PubChem] … A potent lipoxygenase inhibitor that interferes with arachidonic acid metabolism.

Lefamulin

[A183206] Lefamulin is available in intravenous and oral preparations and was granted FDA approval in August 2019. … A pleuromotilin is a more recently developed type of antibiotic that is derived from the fungus, Pleurotus mutilus.

Brotizolam

Brotizolam is a sedative-hypnotic thienodiazepine drug which is a benzodiazepine analog. It demonstrates anxiolytic, anticonvulsant, hypnotic, sedative and skeletal muscle relaxant effects. … Brotizolam is not approved for sale in the UK, United States or Canada but is sold in the Netherlands, Germany, Spain, Belgium, Austria, Portugal, Israel, Italy and Japan.