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Coccidioides immitis spherule
go.drugbank.com/drugs/DB11294ApprovedCoccidioides immitis spherule is a skin test antigen indicated to detect delayed-type hypersensitivity to Coccidioides immitis in individuals with a history of pulmonary coccidioidomycosis.
Suzetrigine
go.drugbank.com/drugs/DB18927ApprovedInvestigationalSuzetrigine is a Na<sub>V</sub>1.8 voltage-gated sodium channel blocker with analgesic properties[A264948] Na<sub>V</sub>1.8 is abundantly expressed in peripheral sensory nerves to play a role in pain … [A264953] On January 30, 2025, suzetrigine was approved by the FDA as a first-in-class non-opioid analgesic.[L52098]
Synonyms: 2-Pyridinecarboxamide, 4-[[[(2R,3S,4S,5R)-3-(3,4-difluoro-2-methoxyphenyl)tetrahydro-4,5-dimethyl-5-(trifluoromethyl)-2-furanyl]carbonyl]amino]-, 4-[(2R,3S,4S,5R)-3-(3,4-difluoro-2-methoxyphenyl)-4,5- dimethyl-5-(trifluoromethyl)oxolane-2- carboxamido]pyridine-2-carboxamideCategories: P-glycoprotein substrates, Cytochrome P-450 CYP2B6 InducersPiflufolastat F 18
go.drugbank.com/drugs/DB14805ApprovedInvestigationalProstate-specific membrane antigen (PSMA) is a transmembrane glycoprotein expressed in many tissues that plays a role in folate uptake and neurotransmitter release - it is expressed in the prostate at … It was first approved by the FDA in May 2021 under the brand name Pylarify and aims to allow for earlier and more accurate detection of suspected prostate cancer metastases or recurrences.
Synonyms: DCFPyL F-18, [F-18] DCFPyLCategories: Heterocyclic Compounds, 1-RingDeflazacort
go.drugbank.com/drugs/DB11921ApprovedIt is marketed by Marathon Pharmaceuticals and was approved in February 2017 by the FDA. … [A179446,A179449,L6697] This disease usually manifests by muscle weakness in early childhood followed by loss of the ability to walk (ambulation) as early as age 7.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InducersSynonyms: 11.BETA.,21-DIHYDROXY-2'-METHYL-5'.BETA.H-PREGNA-1,4-DIENO(17,16-D)OXAZOLE-3,20-DIONE 21-ACETATE, 5'H-PREGNA-1,4-DIENO(17,16-D)OXAZOLE-3,20-DIONE, 21-(ACETYLOXY)-11-HYDROXY-2'-METHYL-, (11.BETA.,16.BETA.)-Acylcarnitine 3-Hydroxydecanoylcarnitine
smpdb.ca/view/SMP0123308MetabolicOnce in the matrix, 3-hydroxydecanoylcarnitine can react with the carnitine O-palmitoyltransferase 2 enzyme found in the mitochondrial inner membrane to once again form 3-hydroxydecanoyl-CoA and L-carnitine … Acetyl-CoA can go on to enter the TCA cycle, or it can react with L-carnitine to form L-acetylcarnitine in a reaction catalyzed by Carnitine O-acetyltransferase.
Drugs: Biotin · Adenosine phosphate · ATP · Levocarnitine · Magnesium cation · Pyrophosphoric acid +1 moreEnzymes: Carnitine O-acetyltransferase, Carnitine O-palmitoyltransferase 2, mitochondrialAcylcarnitine Octacosanoylcarnitine
smpdb.ca/view/SMP0123315MetabolicOnce in the matrix, octacosanoylcarnitine can react with the carnitine O-palmitoyltransferase 2 enzyme found in the mitochondrial inner membrane to once again form octacosanoyl-CoA and L-carnitine. … Acetyl-CoA can go on to enter the TCA cycle, or it can react with L-carnitine to form L-acetylcarnitine in a reaction catalyzed by Carnitine O-acetyltransferase.
Drugs: Biotin · Adenosine phosphate · ATP · Levocarnitine · Magnesium cation · Pyrophosphoric acid +1 moreEnzymes: Carnitine O-acetyltransferase, Carnitine O-palmitoyltransferase 2, mitochondrialAcylcarnitine Nonacosanoylcarnitine
smpdb.ca/view/SMP0123316MetabolicOnce in the matrix, Nonacosanoylcarnitine can react with the carnitine O-palmitoyltransferase 2 enzyme found in the mitochondrial inner membrane to once again form Nonacosanoyl-CoA and L-carnitine. … Acetyl-CoA can go on to enter the TCA cycle, or it can react with L-carnitine to form L-acetylcarnitine in a reaction catalyzed by Carnitine O-acetyltransferase.
Drugs: Biotin · Adenosine phosphate · ATP · Levocarnitine · Magnesium cation · Pyrophosphoric acid +1 moreEnzymes: Carnitine O-acetyltransferase, Carnitine O-palmitoyltransferase 2, mitochondrialAcylcarnitine (2S,3R)-3-Hydroxy-2-methylbutanoylcarnitine
smpdb.ca/view/SMP0123317MetabolicThis reaction is catalyzed by carnitine O-palmitoyltransferase. This enzyme resides in the mitochondrial outer membrane. … Once in the matrix, (2S,3R)-3-hydroxy-2-methylbutanoylcarnitine can react with the carnitine O-palmitoyltransferase 2 enzyme found in the mitochondrial inner membrane to once again form (2S,3R)-3-hydroxy
Drugs: Biotin · Adenosine phosphate · ATP · Levocarnitine · Magnesium cation · Pyrophosphoric acid +1 moreEnzymes: Carnitine O-acetyltransferase, Carnitine O-palmitoyltransferase 2, mitochondrialAcylcarnitine 3-Hydroxy-2-methylbutanoylcarnitine
smpdb.ca/view/SMP0123318MetabolicThis reaction is catalyzed by carnitine O-palmitoyltransferase. This enzyme resides in the mitochondrial outer membrane. … Once in the matrix, 3-hydroxy-2-methylbutanoylcarnitine can react with the carnitine O-palmitoyltransferase 2 enzyme found in the mitochondrial inner membrane to once again form 3-hydroxy-2-methylbutanoyl-CoA
Drugs: Biotin · Adenosine phosphate · ATP · Levocarnitine · Magnesium cation · Pyrophosphoric acid +1 moreEnzymes: Carnitine O-acetyltransferase, Carnitine O-palmitoyltransferase 2, mitochondrialAcylcarnitine 3-oxobutanoylcarnitine
smpdb.ca/view/SMP0123322MetabolicOnce in the matrix, 3-oxobutanoylcarnitine can react with the carnitine O-palmitoyltransferase 2 enzyme found in the mitochondrial inner membrane to once again form 3-oxobutanoyl-CoA and L-carnitine. 3 … Acetyl-CoA can go on to enter the TCA cycle, or it can react with L-carnitine to form L-acetylcarnitine in a reaction catalyzed by Carnitine O-acetyltransferase.
Drugs: Biotin · Adenosine phosphate · ATP · Levocarnitine · Magnesium cation · Pyrophosphoric acid +1 moreEnzymes: Carnitine O-acetyltransferase, Carnitine O-palmitoyltransferase 2, mitochondrial