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Displaying results 3361 - 3370 of 9670 in total
  1. Target

    Lysophosphatidylcholine acyltransferase 1

    go.drugbank.com/bio_entities/BE0017259
    TargetEnzymeHumans

    (PAF) (By similarity). … Involved in platelet-activating factor (PAF) biosynthesis by catalyzing the conversion of the PAF precursor, 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) into 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine

    Synonyms: Lyso-PAF acetyltransferase, Acetyl-CoA:lyso-PAF acetyltransferase
  2. Drug

    Papaverine

    go.drugbank.com/drugs/DB01113
    ApprovedInvestigational

    It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. … The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.

    International brands: Vaso-Pav
  3. Drug

    T487

    go.drugbank.com/drugs/DB05474
    Experimental

    It binds selectively and potently to CXCR3. … The formulation is administered orally and has anti-inflammatory effects in conditions such as rheumatoid arthritis, inflammatory bowel disease and psoriasis.

  4. Drug

    Rocaglamide

    go.drugbank.com/drugs/DB15495
    Experimental

    [A186796] Reports of _Aglaia_ anti-tumor activity date back as far as 1973, and rocaglamide-A was first isolated in 1982 from the species _A. elliptifolia_. … Rocaglamide, also referred to as rocaglamide-A, is the eponymous member of a class of anti-cancer phytochemicals known as rocaglamides.

  5. Drug

    Interferon beta-1a

    go.drugbank.com/drugs/DB00060
    ApprovedInvestigational

    It is produced by mammalian cells (Chinese Hamster Ovary cells) into which the human interferon beta gene has been introduced.

  6. Drug

    scyllo-inositol

    go.drugbank.com/drugs/DB03106
    Investigational

    An isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. … (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379) Inositol phospholipids are important in signal transduction. Scyllitol has been investigated for the treatment of Alzheimer Disease.

  7. Drug

    Pipequaline

    go.drugbank.com/drugs/DB13991
    Experimental

    It is an anxiolytic drug that was never marketed. It presents a unique chemical structure that does not follow the structural properties of other drugs of its class. … However, it presents a significant set of anxiolytic properties with a very little sedative, amnestic or anticonvulsant effect.

  8. Drug

    Zofin

    go.drugbank.com/drugs/DB16519
    Investigational

    Zofin, previously known as Organicell Flow, is a nanoparticle-based therapeutic derived from perinatal sources which is manufactured in a way that retains the naturally occurring microRNAs without the

  9. Drug

    AS-8112

    go.drugbank.com/drugs/DB09207
    Experimental

    It has been shown to exert potent antiemetic effects in animal studies and has been investigated for potential medical use. … AS-8112 is a synthetic compound that acts as a selective antagonist at the dopamine receptor subtypes D2 and D3, and the serotonin receptor 5-HT3.

  10. Drug

    Verpasep caltespen

    go.drugbank.com/drugs/DB04959
    Investigational

    It is being developed by StressGen Biotechnologies Corp. … E7 protein is involved in carcinogenesis of anal and cervical tumors, and represents a tumor antigen that may be specifically targeted by lymphocytes.

    Synonyms: BCG65-E7, HPV 16 E7/HSP65 vaccine