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Mirvetuximab soravtansine
go.drugbank.com/drugs/DB12489ApprovedInvestigationalThis decision was supported by findings from the phase 3 SORAYA trial (NCT04296890).[L43967,L43972] It was subsequently granted full approval in March 2024. … Mirvetuximab soravtansine-gynx (IMGN853) is an antibody-drug conjugate (ADC) formed by a monoclonal antibody (M9346A) that targets folate receptor alpha (FRα), covalently joined by a cleavable disulfide
Categories: Amino Acids, Peptides, and Proteins, Antineoplastic and Immunomodulating AgentsDiflorasone
go.drugbank.com/drugs/DB00223ApprovedDiflorasone is a topical corticosteroid used to treat itching and inflammation of the skin.
Categories: Hormones, Hormone Substitutes, and Hormone AntagonistsCoagulation factor VII human
go.drugbank.com/drugs/DB13150ApprovedInvestigationalCoagulation factor VII is human serine protease type enzyme that is involved in the extrinsic coagulation cascade which results in blood clotting.
Mixtures: OCTAPLEX POWDER AND SOLVENT FOR SOLUTION FOR INJECTION 500 IU, Octaplex Powder and Solvent for Solution for InfusionCategories: Enzymes and Coenzymes, Blood and Blood Forming OrgansFenbufen
go.drugbank.com/drugs/DB08981ApprovedFenbufen acts by preventing cyclooxygenase from producing prostaglandins which can cause inflammation. … It can also be used to relieve backaches, sprains, and fractures. Fenbufen is available as a capsule or tablet sold with the brand names Cepal, Cinopal, Cybufen, Lederfen, and Reugast.
Categories: Antiinflammatory and Antirheumatic Products, Antiinflammatory and Antirheumatic Products, Non-SteroidsTazarotene
go.drugbank.com/drugs/DB00799ApprovedTazarotene, commonly marketed as Tazorac®, Avage®, and Zorac®, is member of the acetylenic class of retinoids. … It is a prodrug that is found in topical formulations used in the treatment of various conditons, such as psoriasis, acne, and sun damaged skin (photodamage).
Categories: tazarotene and ulobetasol, Skin and Mucous Membrane AgentsTropisetron
go.drugbank.com/drugs/DB11699ApprovedInvestigationalWithdrawnTropisetron is an indole derivative with antiemetic activity. … As a selective serotonin receptor antagonist, tropisetron competitively blocks the action of serotonin at 5HT3 receptors, resulting in suppression of chemotherapy- and radiotherapy-induced nausea and vomiting
Categories: Alimentary Tract and Metabolism, Antiemetics and AntinauseantsProducts: NAVOBAN 5MGAlitretinoin
go.drugbank.com/drugs/DB00523ApprovedTretinoin, also known as retinoic acid and derived from maternal vitamin A, is essential for normal growth; and embryonic development. An excess of tretinoin can be teratogenic. … An important regulator of gene expression during growth and development, and in neoplasms.
Categories: Skin and Mucous Membrane Agents, Antineoplastic and Immunomodulating AgentsDehydrocholic acid
go.drugbank.com/drugs/DB11622ApprovedDehydrocholic acid is a synthetic bile acid that was prepared from the oxidation of cholic acid with chromic acid [A33022]. It has been used for stimulation of biliary lipid secretion. … The use of dehydrocholic acid in over-the-counter products has been discontinued by Health Canada.
Categories: Bile Acids and Salts, Cholagogues and CholereticsTabelecleucel
go.drugbank.com/drugs/DB17072ApprovedInvestigationalBoth T-cells and B-cells are obtained from the same donor, and T-cells are grown to increase their numbers. … It is produced by mixing T-cells with B-cells that have been infected with the Epstein-Barr virus (EBV).
Categories: Antineoplastic cell and gene therapy, Antineoplastic and Immunomodulating AgentsFruquintinib
go.drugbank.com/drugs/DB11679ApprovedInvestigationalThis approval is based on favorable results obtained from the FRESCO and FRESCO-2 trials, where an increase in overall survival rate was observed in both trials.[L48791] … [A262102,A262107] Indeed, oncogenic activation, loss of tumor suppressor function, and hypoxia, usually facilitated by cancer cells, are known to upregulate VEGF.
Categories: Antineoplastic and Immunomodulating Agents