Search
Tucatinib
go.drugbank.com/drugs/DB11652ApprovedInvestigationalIt was developed by Seattle Genetics and approved by the FDA on April 17, 2020. … Tucatinib is a kinase inhibitor drug used with [trastuzumab] and [capecitabine] in the treatment of unresectable or metastatic HER-2 positive breast cancer.
Categories: MATE 1 Inhibitors, Heterocyclic Compounds, 1-RingProducts: TUKYSA 50 mg film-coated tablets, TUKYSA (TUCATINIB) FILM-COATED TABLETS 50 mgAmsacrine
go.drugbank.com/drugs/DB00276ApprovedInvestigationalWithdrawnAminoacridine derivative that is a potent intercalating antineoplastic agent. … It is frequently used in combination with other antineoplastic agents in chemotherapy protocols. It produces consistent but acceptable myelosuppression and cardiotoxic effects.
Categories: P-glycoprotein inhibitors, Heterocyclic Compounds, 3-RingSynonyms: m-AMSA, 4'-(9-Acridinylamino)methanesulfon-m-anisidideScopolamine
go.drugbank.com/drugs/DB00747ApprovedInvestigational[A228423, A228758] As a result of its anticholinergic effects, scopolamine is being investigated for diverse therapeutic applications; currently, it is approved for the prevention of nausea and vomiting … [A228758, L31578] Due to its dose-dependent adverse effects, scopolamine was the first drug to be offered commercially as a transdermal delivery system, Scopoderm TTS®, in 1981.
Mixtures: Me-PB-Hyos, Me-PB-HyosCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesNaphazoline
go.drugbank.com/drugs/DB06711ApprovedIt acts to decrease congestion and is found in many over the counter (OTC) eye drops and nasal preparations[L5804,L5807]. … Naphazoline was first developed in 1942 as a nasal formulation for congestion[A176609].
Mixtures: SULFARHIN BURUN MERHEMI, 20 G, SULFARHIN BURUN MERHEMI, 12 GCategories: Adrenergic alpha-2 Receptor Agonists, Heterocyclic Compounds, 1-RingCalcium citrate
go.drugbank.com/drugs/DB11093ApprovedInvestigationalCalcium citrate is a salt typically used as a source of calcium in a variety of over the counter supplements.
Mixtures: CALCIBON D® 315 MG, Citrate De Calcium Plus Vitamine D Et ZincCategories: ascorbic acid (vit C) and calcium, Compounds used in a research, industrial, or household settingEpcoritamab
go.drugbank.com/drugs/DB16672ApprovedInvestigationalAlthough this regimen is effective in up to 60% of patients, patients with relapsed or refractory DLBCL have poor outcomes. … [A259736,A258488,A259761,L46516] Epcoritamab promotes the activation and expansion of T-cells and, by being able to bind to both CD20 and CD3, it leads to the T-cell–mediated killing of CD20+ malignant
Categories: Bispecific CD20-directed CD3 T Cell EngagerProducts: Tepkinly 4 mg/0,8 ml Enjeksiyonluk Çözelti (1 adet), Tepkinly 48 mg Enjeksiyonluk Çözelti (1 adet)Daptomycin
go.drugbank.com/drugs/DB00080ApprovedInvestigational[A231379, A231384, L32534] Chemically, daptomycin comprises 13 amino acids, including several non-standard and D-amino acids, with the C-terminal 10 amino acids forming an ester-linked ring and the N-terminal … [A231379] Daptomycin was approved by the FDA on September 12, 2003, and is marketed under the name CUBICIN® by Cubist Pharmaceuticals LLC (Merck & Co.).[L32534]
Categories: P-glycoprotein substratesProducts: CUBICIN 350 MG ENJEKSİYONLUK ÇÖZELTİ İÇİN TOZ İÇEREN FLAKON, 30 ADET, CUBICIN 500 MG ENJEKSİYONLUK ÇÖZELTİ İÇİN TOZ İÇEREN FLAKON, 30 ADETChlorambucil
go.drugbank.com/drugs/DB00291ApprovedInvestigationalAlthough it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed) … A nitrogen mustard alkylating agent used as antineoplastic agent for the treatment of various malignant and nonmalignant diseases.
Synonyms: N,N-di-2-chloroethyl-γ-p-aminophenylbutyric acid, 4-[p-[bis(2-chloroethyl)amino]phenyl]butyric acidProducts: LEUKERAN 2 MG TABLET, 25 ADET, Leukeran 2 mg - FilmtablettenMelphalan
go.drugbank.com/drugs/DB01042ApprovedInvestigational[L40928] It was first synthesized in the early 1950s by substituting L-phenylalanine for the methyl group on nitrogen mustard. … Melphalan is a nitrogen mustard or bischloroethylamine type alkylating agent.
Synonyms: 3-(p-(Bis(2-chloroethyl)amino)phenyl)-L-alanine, 3-p-(Di(2-chloroethyl)amino)-phenyl-L-alanineProducts: ALKERAN FOR INJECTION 50 mg/vial, ALKERAN 2 MG TABLET, 25 ADETConjugated estrogens
go.drugbank.com/drugs/DB00286ApprovedInvestigationalsulfate, 3% of equilenin sulfate, 5% of 17-alpha and 17-beta-dihydroequilenin sulfate, 2% of 17-alpha-estradiolsulfate and 3% of 17-beta-estradiolsulfate. … [L5605, T475] The conjugated estrogen product contains a mix of estrogen from which about 50% is represented by estrone sulfate followed by 25% of equilin sulfate, 15% of 17-alpha-dehydroequilenin
Mixtures: DUAVİVE 0.45 MG/20 MG DEĞİŞTİRİLMİŞ SALIMLI TABLET, 30 TABLET, DUAVIVE 20 mg/0.45 mg modified - release tabletsCategories: Cytochrome P-450 Substrates, P-glycoprotein substrates