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Alglucosidase alfa
go.drugbank.com/drugs/DB01272ApprovedInvestigationalIt is used for the treatment of Pompe disease (GAA deficiency) in infants and pediatric patients. … Aglucosidase alfa consists of the human enzyme acid alpha-glucosidase (GAA) which is essential for the degradation of glygogen to glucose in lysosomes.
Products: Myozyme Powder for Solution for Injection, (Alglucosidase alfa) 50mg Powder for Solution for InfusionCalcium gluconate
go.drugbank.com/drugs/DB11126ApprovedInvestigationalVet approvedHydrochloric acid and/or sodium hydroxide may have been added for pH adjustment (6.0 to 8.2). … Supplementation may be done to treat or prevent osteoporosis or rickets, consequences of hypocalcemia. It can also be taken by mouth but is not recommended by injection into a muscle.
Products: Calcium Gluconate 10% B.Braun Solution for Injection, Calcium gluconate/ DEMO 10% w/v Solution for injection or infusionCarfilzomib
go.drugbank.com/drugs/DB08889ApprovedInvestigationalFDA approved carfilzomib in July 2012 for the treatment of adults with relapsed or refractory multiple myeloma as monotherapy or combination therapy.[L39392] … Carfilzomib is an injectable antineoplastic agent (IV only). Chemically, it is a modified tetrapeptidyl epoxide and an analog of epoxomicin. It is also a selective proteasome inhibitor.
Categories: P-glycoprotein inhibitors, P-glycoprotein substratesProducts: KYPROLIS POWDER FOR SOLUTION FOR INFUSION 60MG/VIAL, KYPROLIS POWDER FOR SOLUTION FOR INFUSION 30 MG/VIALDaratumumab
go.drugbank.com/drugs/DB09331ApprovedInvestigationalDaratumumab is an immunoglobulin G1 kappa monoclonal antibody developed by Janssen and Genmab. … [L13290] It is approved for the treatment of multiple myeloma as monotherapy or combination therapy and light chain (AL) amyloidosis in combination with other drugs.
Products: DARZALEX CONCENTRATE FOR SOLUTION FOR INFUSION 400MG/20ML, DARZALEX CONCENTRATE FOR SOLUTION FOR INFUSION 100MG/5MLCalcium carbonate
go.drugbank.com/drugs/DB06724ApprovedInvestigationalSubsequent increases in pH may inhibit the action of pepsin. An increase in bicarbonate ions and prostaglandins may also confer cytoprotective effects. … Calcium carbonate may also be used as a nutritional supplement or to treat hypocalcemia.
Mixtures: Cal Mag Tab, Cal-mag Plus K, Mn and Zn CapletsCategories: Drugs for Acid Related DisordersCertolizumab pegol
go.drugbank.com/drugs/DB08904ApprovedInvestigational[A176606] Certolizumab does not require glycosylation for active function and hence, its production is significantly more affordable when compared to other existing TNF-alpha therapies as it can be … [A176606] It was developed and manufactured by UCB Pharma, first FDA approved in 2008[L45018] and updated for a new indication on March 28, 2019.[L5819]
Categories: Biologics for Rheumatoid Arthritis Treatment, Tumor Necrosis Factor Receptor Blocking ActivityProducts: CIMZIA 200MG FER, CIMZIA 200 MG ILO IN FERBrentuximab vedotin
go.drugbank.com/drugs/DB08870ApprovedInvestigationalLymphoma may begin anywhere in the body and can spread to nearby lymph nodes. The two main types of lymphoma are Hodgkin lymphoma (also called Hodgkin disease) and non-Hodgkin lymphoma. … This demonstrates meaningful progress in treatment for patients affected by this disease.[L1739]
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InhibitorsProducts: ADCETRIS 50 MG (POWDER FOR CONCENTRATE FOR SOLUTION FOR INFUSION), POWDER FOR CONCENTRATE FOR SOLUTION FOR INFUSION 50MG/VIALTolfenamic acid
go.drugbank.com/drugs/DB09216ApprovedBy the European Medicine Agency, it was granted in 2016 with the status of orphan for the treatment of supranuclear palsy.[L1291] … It is used in the UK as a treatment for migraine under the name of Clotam.[L1292] In the US, it presents a Status class I by the FDA.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesProducts: TOLFEDINE 4% W/V SOLUTION FOR INJECTION FOR DOGS AND CATS, Tolfine Solution for Injection 4.0% W/VNurulimab
go.drugbank.com/drugs/DB18946InvestigationalNurulimab is under investigation in clinical trial NCT05732805 (A Clinical Study of BCD-217 (Nurulimab + Prolgolimab) Followed by Anti-pd-1 Compared to Anti-pd-1 Monotherapy as First-line Treatment in
Synonyms: Anti-ctla4 mab (biocad)Potassium chloride
go.drugbank.com/drugs/DB00761ApprovedInvestigationalWithdrawnThe FDA withdrew its approval for the use of all solid oral dosage form drug products containing potassium chloride that supply 100 mg or more of potassium per dosage unit, except for controlled-release … A white crystal or crystalline powder used as an electrolyte replenisher, in the treatment of hypokalemia, in buffer solutions, and in fertilizers and explosives.
Mixtures: PEDIALYTE ® MAX 60 MEQ CON ZINC, PEDIALYTE ® MAX 60 MEQ CON ZINCProducts: KALINOR RETARD P, K-dur