Identification

Summary

Calcium gluconate is an ingredient found in a variety of supplements and vitamins, and is used to lower potassium in the blood or treat magnesium poisoning.

Generic Name
Calcium gluconate
DrugBank Accession Number
DB11126
Background

Calcium gluconate is used as mineral supplement and medication when there is insufficient calcium in the diet. Supplementation may be done to treat or prevent osteoporosis or rickets, consequences of hypocalcemia. It can also be taken by mouth but is not recommended by injection into a muscle. Calcium Gluconate Injection, USP is a sterile, nonpyrogenic supersaturated solution of calcium gluconate for intravenous use only. Each mL contains: Calcium gluconate 94 mg; calcium saccharate (tetrahydrate) 4.5 mg; water for injection q.s. Hydrochloric acid and/or sodium hydroxide may have been added for pH adjustment (6.0 to 8.2). Calcium saccharate provides 6% of the total calcium and stabilizes the supersaturated solution of calcium gluconate. Each 10 mL of the injection provides 93 mg elemental calcium (Ca++) equivalent to 1 g of calcium gluconate.

Type
Small Molecule
Groups
Approved, Vet approved
Structure
Thumb
Weight
Average: 430.372
Monoisotopic: 430.0635463
Chemical Formula
C12H22CaO14
Synonyms
  • Calcarea gluconica
  • Calcii gluconas
  • Calcio gluconato
  • Calcium di-gluconate
  • Calcium gluconate
  • Calcium gluconate anhydrous
  • Calcium gluconate, anhydrous
  • D-gluconic acid, calcium salt (2:1)
External IDs
  • E-578
  • INS NO.578
  • INS-578

Pharmacology

Indication

Oral calcium salts are used as dietary supplemental therapy for person who may not get enough calcium in their regular diet. Calcium gluconate is used as a cardioprotective agent in high blood potassium. Calcium gluconate is the antidote for magnesium sulfate toxicity.

Pharmacology
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Associated Conditions
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Contraindications
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Pharmacodynamics

Calcium Gluconate is the gluconate salt of calcium. An element or mineral necessary for normal nerve, muscle, and cardiac function, calcium as the gluconate salt helps to maintain calcium balance and prevent bone loss when taken orally. This agent may also be chemopreventive for colon and other cancers.

Mechanism of action

Calcium is essential for the functional integrity of the nervous, muscular, and skeletal systems. It plays a role in normal cardiac function, renal function, respiration, blood coagulation, and cell membrane and capillary permeability. Also, calcium helps to regulate the release and storage of neurotransmitters and hormones, the uptake and binding of amino acids, absorption of vitamin B 12, and gastrin secretion. The major fraction (99%) of calcium is in the skeletal structure primarily as hydroxyapatite, Ca 10(PO 4) 6(OH) 2; small amounts of calcium carbonate and amorphous calcium phosphates are also present. The calcium of bone is in a constant exchange with the calcium of plasma. Since the metabolic functions of calcium are essential for life, when there is a disturbance in the calcium balance because of dietary deficiency or other causes, the stores of calcium in bone may be depleted to fill the body's more acute needs. Therefore, on a chronic basis, normal mineralization of bone depends on adequate amounts of total body calcium.

Absorption

Approximately one-fifth to one-third of orally administered calcium is absorbed in the small intestine, depending on presence of vitamin D metabolites, pH in lumen, and on dietary factors, such as calcium binding to fiber or phytates. Calcium absorption is increased when a calcium deficiency is present or when a patient is on a low-calcium diet. In patients with achlorhydria or hypochlorhydria, calcium absorption, especially with the carbonate salt, may be reduced.

Volume of distribution

Not available

Protein binding

Moderate, approximately 45% in plasma.

Metabolism

Calcium gluconate does not require hepatic metabolism for the release of Ca++ and is as effective as calcium chloride in treating ionic hypocalcemia in the absence of hepatic function.

Route of elimination

Renal (20%) - The amount excreted in the urine varies with degree of calcium absorption and whether there is excessive bone loss or failure of renal conservation. Fecal (80%) - Consists mainly of nonabsorbed calcium, with only a small amount of endogenous fecal calcium excreted.

Half-life

Not Available

Clearance

Not Available

Adverse Effects
Adverseeffects
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Toxicity

Infants : LDLo (Intramuscular ) : 10gm/kg ; Effects - Brain and coverings : meningeal changes Infants : TDLo ( Intramuscular ) : 143 mg/kg ; Effects - Dermatits Mouse: LD50 ( intravenous ) : 950mg/kg Mouse : LDLo (Oral ) : 10gm/kg

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
AbciximabThe therapeutic efficacy of Calcium gluconate can be decreased when used in combination with Abciximab.
AcebutololThe therapeutic efficacy of Acebutolol can be decreased when used in combination with Calcium gluconate.
AcenocoumarolThe therapeutic efficacy of Calcium gluconate can be decreased when used in combination with Acenocoumarol.
AcetyldigitoxinCalcium gluconate may increase the arrhythmogenic and cardiotoxic activities of Acetyldigitoxin.
Alendronic acidThe serum concentration of Alendronic acid can be decreased when it is combined with Calcium gluconate.
AlfacalcidolThe risk or severity of adverse effects can be increased when Alfacalcidol is combined with Calcium gluconate.
Alpha-1-proteinase inhibitorAlpha-1-proteinase inhibitor may increase the thrombogenic activities of Calcium gluconate.
AlteplaseThe therapeutic efficacy of Calcium gluconate can be decreased when used in combination with Alteplase.
Aminocaproic acidThe risk or severity of adverse effects can be increased when Aminocaproic acid is combined with Calcium gluconate.
AmiodaroneThe therapeutic efficacy of Amiodarone can be decreased when used in combination with Calcium gluconate.
Interactions
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Food Interactions
  • Take with a full glass of water.
  • Take with food.

Products

Products2
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dosage, form, labeller, route of administration, and marketing period.
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Product Ingredients
IngredientUNIICASInChI Key
Calcium gluconate monohydrateCZN0MI5R3166905-23-5XLNFVCRGJZBQGX-XRDLMGPZSA-L
Active Moieties
NameKindUNIICASInChI Key
CalciumunknownSY7Q814VUP7440-70-2OYPRJOBELJOOCE-UHFFFAOYSA-N
Calcium cationionic2M83C4R6ZB14127-61-8BHPQYMZQTOCNFJ-UHFFFAOYSA-N
Brand Name Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
Calcium GluconateInjection, solution94 mg/1mLIntravenousGeneral Injectables & Vaccines2015-06-112017-07-31US flag
Calcium GluconateInjection, solution20 mg/1mLIntravenousWG Critical Care, LLC2018-10-26Not applicableUS flag
Calcium GluconateInjection, solution98 mg/1mLIntravenousAMERICAN REGENT, INC.1992-12-012017-08-31US flag
Calcium GluconateInjection, solution20 mg/1mLIntravenousFresenius Kabi USA, LLC2021-06-17Not applicableUS flag
Calcium GluconateInjection, solution94 mg/1mLIntravenousRemedy Repack2015-06-192017-07-25US flag
Calcium GluconateInjection, solution98 mg/1mLIntravenousGeneral Injectables and Vaccines, Inc.2018-02-12Not applicableUS flag
Calcium GluconateInjection, solution98 mg/1mLIntravenousHF Acquisition Co LLC, DBA HealthFirst2018-10-18Not applicableUS flag
Calcium GluconateInjection, solution94 mg/1mLIntravenousFresenius Kabi USA, LLC2000-07-122016-02-29US flag
Calcium GluconateInjection, solution94 mg/1mLIntravenousRemedy Repack2015-03-162017-03-17US flag
Calcium GluconateInjection, solution20 mg/1mLIntravenousWG Critical Care, LLC2018-10-26Not applicableUS flag
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
CALCIUM GLUCONATE INJECTION 10%Injection940 mg/10mlIntramuscular; IntravenousB. BRAUN SINGAPORE PTE LTD1991-04-08Not applicable
Calcium Gluconate Tab 600mgTablet600 mgOralSwiss Herbal Remedies Ltd.1983-12-312003-09-10Canada flag
Calcium Gluconate Tab 648mgTablet648 mgOralHall Laboratories, Ltd.1981-12-312003-09-11Canada flag
Calcium Gluconate Tab 648mgTablet648 mgOralPharmetics (2011) Inc.1973-12-312000-08-21Canada flag
Calcium Gluconate Tab 648mg USPTablet648 mgOralLab Gernetic Int Ltee1985-12-311997-02-21Canada flag
Calcium Gluconate Tab 650mgTablet650 mgOralVita Health Products Inc1972-12-312002-07-31Canada flag
Calcium Gluconate Tab 650mgTablet650 mgOralShoppers Drug Mart Inc.1978-12-311997-08-15Canada flag
Calcium Gluconate Tab 650mgTablet650 mgOralD.C. Labs Limited1969-12-312005-07-19Canada flag
Calcium Gluconate Tab 650mgTablet650 mg / tabOralWampole Brands, A Division Of Pangeo Pharma (Canada) Inc.1979-12-311996-09-09Canada flag
Calcium Gluconate Tablets 648mg USPTablet648 mgOralVita Health Products Inc1988-12-312002-07-31Canada flag
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
CALCİLES 225 MG+572 MG/10 ML ENJEKSİYONLUK ÇÖZELTİ, 5 ADETCalcium gluconate monohydrate (225 mg/10mL) + Calcium levulinate (572 mg/10mL)Injection, solutionParenteralVEM İLAÇ SAN. VE TİC. A.Ş.2020-08-14Not applicableTurkey flag
CALCIO AL 10% AMPOLLASCalcium gluconate monohydrate (600 mg) + Calcium levulinate (400 mg)SolutionIntravenousLABORATORIOS RYAN DE COLOMBIA S.A.S.2008-10-07Not applicableColombia flag
CALCİOSEL 225 mg + 572 mg / 10 mL ENJEKSIYONLUK ÇÖZELTICalcium gluconate monohydrate (225 mg/10ml) + Calcium levulinate dihydrate (572 mg/10ml)InjectionIntramuscularHAVER FARMA İLAÇ A.Ş.2020-08-14Not applicableTurkey flag
CALCIUM GLUCONATE INJECTION USP 10%Calcium gluconate (94 mg/ml) + Calcium saccharate (4.5 mg/ml)InjectionIntravenousFRESENIUS KABI (SINGAPORE) PTE LTD1995-11-24Not applicable
Calcium LiquidCalcium gluconate (112 mg / mL) + Calcium glucoheptonate (132 mg / mL)LiquidOralShoppers Drug Mart Inc.1981-12-311997-08-15Canada flag
Calcium LiquidCalcium gluconate (112 mg / mL) + Calcium glucoheptonate (132 mg / mL)LiquidOralKsl Pharmaceuticals1994-12-311996-09-09Canada flag
Calcium LiquidCalcium gluconate (112 mg / mL) + Calcium glucoheptonate (132 mg / mL)LiquidOralVita Health Products Inc1980-12-312002-07-31Canada flag
Calcium Magnesium Plus Vitamin D LiquidCalcium gluconate (6 mg / mL) + Ergocalciferol (2 unit / mL) + Inositol (.6 mg / mL) + Magnesium citrate (3 mg / mL)LiquidOralJamp Pharma Corporation2002-04-222003-02-05Canada flag
CALCIUM PICKEN %10 ENJEKSİYONLUK ÇÖZELTİ 100 AMPULCalcium gluconate monohydrate (225 mg) + Calcium levulinate dihydrate (572 mg)InjectionIntramuscularADEKA İLAÇ SAN. VE TİC. A.Ş.2020-08-14Not applicableTurkey flag
CALCIUM PICKEN %10 ENJEKSİYONLUK ÇÖZELTİ 50 AMPULCalcium gluconate monohydrate (225 mg) + Calcium levulinate dihydrate (572 mg)InjectionIntramuscularADEKA İLAÇ SAN. VE TİC. A.Ş.2020-08-14Not applicableTurkey flag
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
Calcium GluconateCalcium gluconate (94 mg/1mL)Injection, solutionIntravenousRemedy Repack2015-10-082016-10-08US flag
Calcium GluconateCalcium gluconate (94 mg/1mL)Injection, solutionIntravenousFresenius Kabi USA, LLC2000-07-122016-02-29US flag
Calcium GluconateCalcium gluconate (0.465 meq/1mL)Injection, solutionIntravenousGeneral Injectables & Vaccines2010-04-012013-12-01US flag
Calcium GluconateCalcium gluconate monohydrate (98 mg/1mL)Injection, solutionIntravenousAMERICAN REGENT, INC.1990-09-302014-01-31US flag
Calcium GluconateCalcium gluconate (94 mg/1mL)Injection, solutionIntravenousGeneral Injectables & Vaccines2015-06-112017-07-31US flag
Calcium GluconateCalcium gluconate (94 mg/1mL)Injection, solutionIntravenousA-S Medication Solutions2000-08-092018-03-31US flag
Calcium GluconateCalcium gluconate (94 mg/1mL)Injection, solutionIntravenousRemedy Repack2015-06-192017-07-25US flag
Calcium GluconateCalcium gluconate (94 mg/1mL)Injection, solutionIntravenousRemedy Repack2015-03-162017-03-17US flag
Calcium GluconateCalcium gluconate monohydrate (98 mg/1mL)Injection, solutionIntravenousAMERICAN REGENT, INC.1992-12-012017-08-31US flag
Calcium GluconateCalcium gluconate (94 mg/1mL)Injection, solutionIntravenousCardinal Health2000-08-092016-01-31US flag

Categories

ATC Codes
A12AA03 — Calcium gluconateD11AX03 — Calcium gluconate
Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as sugar acids and derivatives. These are compounds containing a saccharide unit which bears a carboxylic acid group.
Kingdom
Organic compounds
Super Class
Organic oxygen compounds
Class
Organooxygen compounds
Sub Class
Carbohydrates and carbohydrate conjugates
Direct Parent
Sugar acids and derivatives
Alternative Parents
Medium-chain hydroxy acids and derivatives / Medium-chain fatty acids / Beta hydroxy acids and derivatives / Hydroxy fatty acids / Monosaccharides / Secondary alcohols / Carboxylic acid salts / Polyols / Carboxylic acids / Organic calcium salts
show 6 more
Substituents
Alcohol / Aliphatic acyclic compound / Beta-hydroxy acid / Carbonyl group / Carboxylic acid / Carboxylic acid derivative / Carboxylic acid salt / Fatty acid / Fatty acyl / Gluconic_acid
show 14 more
Molecular Framework
Not Available
External Descriptors
Not Available
Affected organisms
Not Available

Chemical Identifiers

UNII
SQE6VB453K
CAS number
299-28-5
InChI Key
NEEHYRZPVYRGPP-IYEMJOQQSA-L
InChI
InChI=1S/2C6H12O7.Ca/c2*7-1-2(8)3(9)4(10)5(11)6(12)13;/h2*2-5,7-11H,1H2,(H,12,13);/q;;+2/p-2/t2*2-,3-,4+,5-;/m11./s1
IUPAC Name
calcium bis((2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoate)
SMILES
[Ca++].[H][C@@](O)(CO)[C@@]([H])(O)[C@]([H])(O)[C@@]([H])(O)C([O-])=O.[H][C@@](O)(CO)[C@@]([H])(O)[C@]([H])(O)[C@@]([H])(O)C([O-])=O

References

General References
  1. Martin TJ, Kang Y, Robertson KM, Virji MA, Marquez JM: Ionization and hemodynamic effects of calcium chloride and calcium gluconate in the absence of hepatic function. Anesthesiology. 1990 Jul;73(1):62-5. [Article]
  2. DRUGS.COM [Link]
  3. Pubchem [Link]
  4. ChemIDplus [Link]
  5. DRUGS.COM [Link]
  6. TITCK Product Information: Calciles (calcium gluconate/calcium levulinate) solution for injection [Link]
KEGG Compound
C08133
PubChem Compound
9290
PubChem Substance
347827907
ChemSpider
8932
RxNav
1908
ChEBI
3309
ChEMBL
CHEMBL2106119
Wikipedia
Calcium_gluconate

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
4RecruitingPreventionHypocalcemia1
3CompletedDiagnosticBreast Cancer / Osteoporosis1
3CompletedPreventionOvarian Hyperstimulation1
3CompletedSupportive CareChemotherapeutic Agent Toxicity / Colorectal Carcinoma (CRC) / Neurologic toxicity / Neuropathies1
3CompletedSupportive CareColorectal Carcinoma (CRC) / Neurologic toxicity1
3TerminatedSupportive CareCarcinoma Breast Stage IV / Neuropathies / Pain / Recurrent Breast Carcinoma1
3TerminatedSupportive CareOsteoporosis / Prostate Cancer1
2CompletedPreventionOHSS1
2CompletedPreventionPeripheral neuropathy1
2CompletedSupportive CareBreast Cancer Stage IIIc / Breast Cancer, Stage II / Breast Cancer, Stage IIIB / Early Breast Cancer / Joint Pain / Musculoskeletal Complications / Pain / Recurrent Breast Cancer / Stage IIIA Breast Cancer1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
Injection, solutionParenteral
SolutionIntravenous
Injection, solution
InjectionIntramuscular
Injection, solutionIntravenous
InjectionIntramuscular; Intravenous100 MG/ML
InjectionIntravenous
Injection, solutionIntravenous0.465 meq/1mL
Injection, solutionIntravenous10 mg/1mL
Injection, solutionIntravenous20 mg/1mL
Injection, solutionIntravenous94 mg/1mL
Injection, solutionIntravenous98 mg/1mL
TabletOral500 mg/1
LiquidIntravenous100 mg / mL
SolutionIntravenous100 mg / mL
SolutionIntramuscular; Intravenous100 mg / mL
SolutionIntravenous.465 mEq / mL
InjectionIntramuscular; Intravenous940 mg/10ml
SolutionIntravenous94 mg / mL
InjectionIntravenous94 mg/ml
SolutionIntravenous
TabletOral600 mg
TabletOral648 mg
TabletOral650 mg / tab
TabletOral650 mg
LiquidOral
Injection, solutionParenteral
GelTopical2.5 g/100g
TabletOral
LiquidIntravenous10 % / kit
PowderOral
SolutionIntravenous940 mg
GelTopical2.5 % w/w
InjectionIntramuscular; Intravenous94 mg/ml
LiquidIntravenous
Tablet, delayed releaseOral
DoucheVaginal
Solution0.45 mEq/1ml
Tablet, effervescent
Tablet, chewableOral600 mg
Solution100 mg/1ml
TabletOral500 mg
Prices
Not Available
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)Region
US10130646No2018-11-202038-01-11US flag
US10342813No2019-07-092037-07-25US flag

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility44.2 mg/mLALOGPS
logP-2ALOGPS
logP-3.4ChemAxon
logS-0.99ALOGPS
pKa (Strongest Acidic)3.39ChemAxon
pKa (Strongest Basic)-3ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count7ChemAxon
Hydrogen Donor Count5ChemAxon
Polar Surface Area141.28 Å2ChemAxon
Rotatable Bond Count10ChemAxon
Refractivity49.11 m3·mol-1ChemAxon
Polarizability16.62 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Drug created at December 03, 2015 16:51 / Updated at October 26, 2021 21:40