Calcium gluconate



Calcium gluconate is an ingredient found in a variety of supplements and vitamins, and is used to lower potassium in the blood or treat magnesium poisoning.

Generic Name
Calcium gluconate
DrugBank Accession Number

Calcium gluconate is used as mineral supplement and medication when there is insufficient calcium in the diet. Supplementation may be done to treat or prevent osteoporosis or rickets, consequences of hypocalcemia. It can also be taken by mouth but is not recommended by injection into a muscle. Calcium Gluconate Injection, USP is a sterile, nonpyrogenic supersaturated solution of calcium gluconate for intravenous use only. Each mL contains: Calcium gluconate 94 mg; calcium saccharate (tetrahydrate) 4.5 mg; water for injection q.s. Hydrochloric acid and/or sodium hydroxide may have been added for pH adjustment (6.0 to 8.2). Calcium saccharate provides 6% of the total calcium and stabilizes the supersaturated solution of calcium gluconate. Each 10 mL of the injection provides 93 mg elemental calcium (Ca++) equivalent to 1 g of calcium gluconate.

Small Molecule
Approved, Vet approved
Average: 430.372
Monoisotopic: 430.0635463
Chemical Formula
  • Calcarea gluconica
  • Calcii gluconas
  • Calcio gluconato
  • Calcium di-gluconate
  • Calcium gluconate
  • Calcium gluconate anhydrous
  • Calcium gluconate, anhydrous
  • D-gluconic acid, calcium salt (2:1)
External IDs
  • E-578
  • INS NO.578
  • INS-578



Oral calcium salts are used as dietary supplemental therapy for person who may not get enough calcium in their regular diet. Calcium gluconate is used as a cardioprotective agent in high blood potassium. Calcium gluconate is the antidote for magnesium sulfate toxicity.

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Associated Conditions
Indication TypeIndicationCombined Product DetailsApproval LevelAge GroupPatient CharacteristicsDose Form
Used in combination to preventBone and tooth decayCombination Product in combination with: Calcium citrate (DB11093), Calcium carbonate (DB06724), Cholecalciferol (DB00169)••• ••••••••••• •••••• ••••••••• •••••
Used in combination to maintainBone and tooth growthCombination Product in combination with: Cholecalciferol (DB00169), Calcium carbonate (DB06724), Calcium citrate (DB11093)••• •••
Used in combination to preventCalcium deficiencyCombination Product in combination with: Cholecalciferol (DB00169), Calcium Phosphate (DB11348), Calcium lactate (DB13231)•••••••••••••••••••••••••••••••
Used in combination to preventCalcium deficiencyCombination Product in combination with: Cholecalciferol (DB00169), Calcium lactate (DB13231), Calcium Phosphate (DB11348)•••••••••••••••••••••••••••
Used in combination to treatHypocalcemiaCombination Product in combination with: Calcium levulinate (DB13800)•••••••••••••••••••••• ••••••••• ••••••••
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Calcium Gluconate is the gluconate salt of calcium. An element or mineral necessary for normal nerve, muscle, and cardiac function, calcium as the gluconate salt helps to maintain calcium balance and prevent bone loss when taken orally. This agent may also be chemopreventive for colon and other cancers.

Mechanism of action

Calcium is essential for the functional integrity of the nervous, muscular, and skeletal systems. It plays a role in normal cardiac function, renal function, respiration, blood coagulation, and cell membrane and capillary permeability. Also, calcium helps to regulate the release and storage of neurotransmitters and hormones, the uptake and binding of amino acids, absorption of vitamin B 12, and gastrin secretion. The major fraction (99%) of calcium is in the skeletal structure primarily as hydroxyapatite, Ca 10(PO 4) 6(OH) 2; small amounts of calcium carbonate and amorphous calcium phosphates are also present. The calcium of bone is in a constant exchange with the calcium of plasma. Since the metabolic functions of calcium are essential for life, when there is a disturbance in the calcium balance because of dietary deficiency or other causes, the stores of calcium in bone may be depleted to fill the body's more acute needs. Therefore, on a chronic basis, normal mineralization of bone depends on adequate amounts of total body calcium.


Approximately one-fifth to one-third of orally administered calcium is absorbed in the small intestine, depending on presence of vitamin D metabolites, pH in lumen, and on dietary factors, such as calcium binding to fiber or phytates. Calcium absorption is increased when a calcium deficiency is present or when a patient is on a low-calcium diet. In patients with achlorhydria or hypochlorhydria, calcium absorption, especially with the carbonate salt, may be reduced.

Volume of distribution

Not available

Protein binding

Moderate, approximately 45% in plasma.


Calcium gluconate does not require hepatic metabolism for the release of Ca++ and is as effective as calcium chloride in treating ionic hypocalcemia in the absence of hepatic function.

Route of elimination

Renal (20%) - The amount excreted in the urine varies with degree of calcium absorption and whether there is excessive bone loss or failure of renal conservation. Fecal (80%) - Consists mainly of nonabsorbed calcium, with only a small amount of endogenous fecal calcium excreted.


Not Available


Not Available

Adverse Effects
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Infants : LDLo (Intramuscular ) : 10gm/kg ; Effects - Brain and coverings : meningeal changes Infants : TDLo ( Intramuscular ) : 143 mg/kg ; Effects - Dermatits Mouse: LD50 ( intravenous ) : 950mg/kg Mouse : LDLo (Oral ) : 10gm/kg

Not Available
Pharmacogenomic Effects/ADRs
Not Available


Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
AcebutololThe therapeutic efficacy of Acebutolol can be decreased when used in combination with Calcium gluconate.
AcetyldigitoxinCalcium gluconate may increase the arrhythmogenic and cardiotoxic activities of Acetyldigitoxin.
Alendronic acidThe serum concentration of Alendronic acid can be decreased when it is combined with Calcium gluconate.
AlfacalcidolThe risk or severity of adverse effects can be increased when Alfacalcidol is combined with Calcium gluconate.
AmiodaroneThe therapeutic efficacy of Amiodarone can be decreased when used in combination with Calcium gluconate.
Food Interactions
  • Take with a full glass of water.
  • Take with food.


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Product Ingredients
IngredientUNIICASInChI Key
Calcium gluconate monohydrateCZN0MI5R3166905-23-5XLNFVCRGJZBQGX-XRDLMGPZSA-L
Active Moieties
Calcium cationionic2M83C4R6ZB14127-61-8BHPQYMZQTOCNFJ-UHFFFAOYSA-N
Brand Name Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
2% Calcium Gluconate In Sodium Chloride InjectionSolution20 mg / mLIntravenousFresenius KabiNot applicableNot applicableCanada flag
Calcium GluconateInjection, solution98 mg/1mLIntravenousGeneral Injectables and Vaccines, Inc.2018-02-122024-03-31US flag
Calcium GluconateInjection, solution98 mg/1mLIntravenousMedical Purchasing Solutions, Llc2017-06-15Not applicableUS flag
Calcium GluconateInjection, solution94 mg/1mLIntravenousRemedy Repack2015-03-162017-03-17US flag
Calcium GluconateInjection, solution98 mg/1mLIntravenousAMERICAN REGENT, INC.1992-12-012017-08-31US flag
Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
Calcium GluconateInjection, solution98 mg/1mLIntravenousHikma Pharmaceuticals USA Inc.2023-10-16Not applicableUS flag
Calcium GluconateInjection, solution20 mg/1mLIntravenousAmneal Pharmaceuticals Private Limited2023-09-08Not applicableUS flag
Calcium GluconateInjection, solution98 mg/1mLIntravenousNivagen Pharmaceuticals, Inc.2022-10-24Not applicableUS flag
Calcium GluconateInjection, solution98 mg/1mLIntravenousSomerset Therapeutics, Llc2023-10-20Not applicableUS flag
Calcium GluconateInjection, solution20 mg/1mLIntravenousAmneal Pharmaceuticals Private Limited2023-09-08Not applicableUS flag
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
CALCIUM GLUCONATE INJECTION 10%Injection940 mg/10mlIntramuscular; IntravenousB. BRAUN SINGAPORE PTE LTD1991-08-04Not applicableSingapore flag
Calcium Gluconate Tab 600mgTablet600 mgOralSwiss Herbal Remedies Ltd.1983-12-312003-09-10Canada flag
Calcium Gluconate Tab 648mgTablet648 mgOralHall Laboratories, Ltd.1981-12-312003-09-11Canada flag
Calcium Gluconate Tab 648mgTablet648 mgOralPharmetics (2011) Inc.1973-12-312000-08-21Canada flag
Calcium Gluconate Tab 648mg USPTablet648 mgOralLab Gernetic Int Ltee1985-12-311997-02-21Canada flag
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
CALCİLES 225 MG+572 MG/10 ML ENJEKSİYONLUK ÇÖZELTİ, 5 ADETCalcium gluconate monohydrate (225 mg/10mL) + Calcium levulinate (572 mg/10mL)Injection, solutionParenteralVEM İLAÇ SAN. VE TİC. A.Ş.2018-03-14Not applicableTurkey flag
CALCIO AL 10% AMPOLLASCalcium gluconate monohydrate (600 mg) + Calcium levulinate (400 mg)SolutionIntravenousLABORATORIOS RYAN DE COLOMBIA S.A.S.2008-10-07Not applicableColombia flag
CALCİOSEL 225 mg + 572 mg / 10 mL ENJEKSIYONLUK ÇÖZELTICalcium gluconate monohydrate (225 mg/10ml) + Calcium levulinate dihydrate (572 mg/10ml)InjectionIntramuscularHAVER FARMA İLAÇ A.Ş.2016-04-20Not applicableTurkey flag
Calcium "Fresenius" - AmpullenCalcium gluconate (0.95 g) + Calcium saccharate (0.036 g)Injection, solutionIntravenousFresenius Kabi Austria Gmb H1987-09-01Not applicableAustria flag
CALCIUM GLUCONATE INJECTION USP 10%Calcium gluconate (94 mg/ml) + Calcium saccharate (4.5 mg/ml)InjectionIntravenousFRESENIUS KABI (SINGAPORE) PTE LTD1995-11-24Not applicableSingapore flag
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
Calcium GluconateCalcium gluconate (94 mg/1mL)Injection, solutionIntravenousRemedy Repack2015-03-162017-03-17US flag
Calcium GluconateCalcium gluconate (94 mg/1mL)Injection, solutionIntravenousCardinal Health2000-08-092016-01-31US flag
Calcium GluconateCalcium gluconate monohydrate (98 mg/1mL)Injection, solutionIntravenousAMERICAN REGENT, INC.1992-12-012017-08-31US flag
Calcium GluconateCalcium gluconate (94 mg/1mL)Injection, solutionIntravenousRemedy Repack2015-10-082016-10-08US flag
Calcium GluconateCalcium gluconate (0.465 meq/1mL)Injection, solutionIntravenousGeneral Injectables & Vaccines2010-04-012013-12-01US flag


ATC Codes
A12AA03 — Calcium gluconateD11AX03 — Calcium gluconate
Drug Categories
Chemical TaxonomyProvided by Classyfire
This compound belongs to the class of organic compounds known as sugar acids and derivatives. These are compounds containing a saccharide unit which bears a carboxylic acid group.
Organic compounds
Super Class
Organic oxygen compounds
Organooxygen compounds
Sub Class
Carbohydrates and carbohydrate conjugates
Direct Parent
Sugar acids and derivatives
Alternative Parents
Medium-chain hydroxy acids and derivatives / Medium-chain fatty acids / Beta hydroxy acids and derivatives / Hydroxy fatty acids / Monosaccharides / Secondary alcohols / Carboxylic acid salts / Polyols / Carboxylic acids / Organic calcium salts
show 6 more
Alcohol / Aliphatic acyclic compound / Beta-hydroxy acid / Carbonyl group / Carboxylic acid / Carboxylic acid derivative / Carboxylic acid salt / Fatty acid / Fatty acyl / Gluconic_acid
show 14 more
Molecular Framework
Not Available
External Descriptors
Not Available
Affected organisms
Not Available

Chemical Identifiers

CAS number
InChI Key
calcium bis((2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoate)


General References
  1. Martin TJ, Kang Y, Robertson KM, Virji MA, Marquez JM: Ionization and hemodynamic effects of calcium chloride and calcium gluconate in the absence of hepatic function. Anesthesiology. 1990 Jul;73(1):62-5. [Article]
  2. DRUGS.COM [Link]
  3. Pubchem [Link]
  4. ChemIDplus [Link]
  5. DRUGS.COM [Link]
  6. TITCK Product Information: Calciles (calcium gluconate/calcium levulinate) solution for injection [Link]
KEGG Compound
PubChem Compound
PubChem Substance

Clinical Trials

Clinical Trials
4Unknown StatusPreventionHypocalcemia1
3CompletedDiagnosticBreast Cancer / Osteoporosis1
3CompletedPreventionOvarian Hyperstimulation1
3CompletedSupportive CareChemotherapeutic Agent Toxicity / Colorectal Cancer / Neurologic toxicity / Neuropathy1
3CompletedSupportive CareColorectal Cancer / Neurologic toxicity1


Not Available
Not Available
Dosage Forms
SolutionIntravenous20 mg / mL
SolutionParenteral1.000 g
Injection, solutionParenteral
Injection, solution
InjectionIntramuscular; Intravenous100 MG/ML
Injection, solutionIntravenous0.465 meq/1mL
Injection, solutionIntravenous94 mg/1mL
Injection, solutionIntravenous98 mg/1mL
TabletOral500 mg/1
LiquidIntravenous100 mg / mL
Injection, solutionIntravenous10 mg/1mL
Injection, solutionIntravenous20 mg/1mL
SolutionIntravenous100 mg / mL
SolutionIntramuscular; Intravenous100 mg / mL
SolutionIntravenous.465 mEq / mL
InjectionIntramuscular; Intravenous940 mg/10ml
SolutionIntravenous94 mg / mL
InjectionIntravenous94 mg/ml
TabletOral600 mg
TabletOral648 mg
TabletOral650 mg
TabletOral650 mg / tab
TabletOral60 mg
Injection, solutionParenteral10 %
GelTopical2.5 g/100g
Injection, solutionIntravenous
LiquidIntravenous10 % / kit
Solution0.9500 g
SolutionIntravenous940 mg
GelTopical2.5 % w/w
InjectionIntramuscular; Intravenous94 mg/ml
Tablet, delayed releaseOral
Solution0.45 mEq/1ml
Tablet, effervescent
Tablet, chewableOral600 mg
Solution100 mg/1ml
TabletOral500 mg
Not Available
Patent NumberPediatric ExtensionApprovedExpires (estimated)Region
US10130646No2018-11-202038-01-11US flag
US10342813No2019-07-092037-07-25US flag


Not Available
Experimental Properties
Not Available
Predicted Properties
Water Solubility44.2 mg/mLALOGPS
pKa (Strongest Acidic)3.39Chemaxon
pKa (Strongest Basic)-3Chemaxon
Physiological Charge-1Chemaxon
Hydrogen Acceptor Count7Chemaxon
Hydrogen Donor Count5Chemaxon
Polar Surface Area141.28 Å2Chemaxon
Rotatable Bond Count10Chemaxon
Refractivity49.11 m3·mol-1Chemaxon
Polarizability16.62 Å3Chemaxon
Number of Rings0Chemaxon
Rule of FiveYesChemaxon
Ghose FilterNoChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon
Predicted ADMET Features
Not Available


Mass Spec (NIST)
Not Available
Not Available
Chromatographic Properties
Collision Cross Sections (CCS)
AdductCCS Value (Å2)Source typeSource
DeepCCS 1.0 (2019)
DeepCCS 1.0 (2019)
DeepCCS 1.0 (2019)

Drug created at December 03, 2015 16:51 / Updated at March 03, 2024 18:31