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Displaying results 3431 - 3440 of 10000 in total
  1. Drug

    Unoprostone

    go.drugbank.com/drugs/DB06826
    ApprovedWithdrawn

    Unoprostone isopropyl has the chemical name isopropyl (+)-(Z)-7-[(1R,2R,3R,5S)-3,5 dihydroxy-2-(3-oxodecyl)cyclopentyl]-5-heptenoate. The main indication of Unoprostane is treatment of glucoma.

    Synonyms: 13,14-dihydro-15-keto-20-ethyl PGF2α
  2. Drug

    Ty800

    go.drugbank.com/drugs/DB04989
    Investigational

    The Ty800 vaccine was developed using genetic techniques to delete specific genes known to be essential to the virulence of <i>S. typhi</i>. It is being developed by AVANT Immunotherapeutics, Inc. … Ty800 is a vaccine designed to offer rapid, oral, single-dose protection against <i>Salmonella typhi</i>, the cause of typhoid fever.

  3. Drug

    AMG 424

    go.drugbank.com/drugs/DB17357
    Investigational

    AMG 424 is a novel, humanized, anti-CD3/CD38 bispecific monoclonal antibody being investigated for multiple myeloma.

    Synonyms: AMG-424, Humanized Bi-Specific Xmab(R) T Cell Recruiting Antibody Construct Directed Against Cd3 And Cd38
  4. Drug

    Volanesorsen

    go.drugbank.com/drugs/DB15067
    Approved

    Volanesorsen is an antisense oligonucleotide that binds to apoC-III mRNA to prevent its translation. … [L16621] Volanesorsen was granted a conditional approval by the European Medicines Agency.[L16621]

  5. Indication

    Dementia With Lewy Body Disease

    go.drugbank.com/conditions/DBCOND0077924
    Drugs: Donepezil · Rivastigmine
    Synonyms: Late onset dementia due to Lewy body disease (disorder)
  6. Indication

    Head Injury

    go.drugbank.com/conditions/DBCOND0028168
    Drugs: Cerebrolysin
    Synonyms: [X]Injuries to the head (disorder)
  7. Indication

    Hospital-Acquired Pneumonia

    go.drugbank.com/conditions/DBCOND0038730
    Drugs: Amikacin · Cefiderocol · Ceftazidime · Ceftolozane · Ciprofloxacin · Piperacillin +5 more
    Synonyms: Pneumonia due to bacteria NOS (disorder)
  8. Drug

    Vimseltinib

    go.drugbank.com/drugs/DB17520
    ApprovedInvestigational

    [L52230] It is highly selective, with a >500-fold selectivity for CSF1R over its nearest off-target kinase. … [A265035] It is intended to provide a safer alternative to [pexidartinib], a previously approved CSF1R inhibitor associated with significant liver toxicity - the greater selectivity of vimseltinib results

    Synonyms: 2-(isopropylamino)-3-methyl-5-(6-methyl-5-((2-(1-methyl-1h-pyrazol-4-yl)pyridin-4-yl)oxy)pyridin-2-yl)pyrimidin-4(3h)-one, 3-methyl-2-((1-methylethyl)amino)-5-(6-methyl-5-((2-(1-methyl-1h-pyrazol-4-yl)-4-pyridinyl)oxy)-2-pyridinyl)-4(3h)-pyrimidinone
  9. Drug

    Phosphoaminophosphonic acid guanylate ester

    go.drugbank.com/drugs/DB02082
    Experimental

    A non-hydrolyzable analog of GTP, in which the oxygen atom bridging the beta to the gamma phosphate is replaced by a nitrogen atom. It binds tightly to G-protein in the presence of Mg2+.

    Synonyms: 5'-guanylylimidodiphosphate, Guanosine 5'-[beta,gamma-imido]triphosphate
  10. Drug

    Ponesimod

    go.drugbank.com/drugs/DB12016
    ApprovedInvestigational

    [A232079] Fingolimod's activity at sphingosine 1-phosphate receptor 3 was suspected to be responsible for a portion of it's adverse effects, and so more selective modulators were developed.

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Substrates