Vimseltinib is a highly selective CSF1R inhibitor for the treatment of symptomatic tenosynovial giant cell tumours for which surgical intervention is not appropriate. Vimseltinib is a small molecule kinase inhibitor targeting colony-stimulating factor 1 receptor (CSF1R).
- Mechanism
- Curator reviewed · 5 references
Vimseltinib is a kinase inhibitor targeting colony-stimulating factor 1 receptor (CSF1R), a type III receptor tyrosine kinase which is crucial for survival, proliferation, and differentiation of myeloid lineage cells such as macrophages, microglial cells and osteoclasts. Abnormal CSF1R signaling has been observed in several diseases including cancer, arthritis, inflammatory disorders, Alzheimer’s Disease, and Parkinson’s Disease.
Vimseltinib specifically acts by stabilizing CSF1R in its inactive state by exploiting its switch-control region, thereby inhibiting autophosphorylation, downstream signaling induced by CSF1 ligand binding, and proliferation of cells expressing CSF1R.
- Primary indication
- Vimseltinib is indicated for the treatment of adult patients with symptomatic tenosynovial giant cell tumor for which surgical resection will potentially cause worsening functional limitation or severe morbidity.Curator reviewed · 1 structured indication
- Formula / weight
- C23H25N7O2 · 431.5 g/mol (avg)
- First approval
- United States, 2025
- Also known as
- 2-(isopropylamino)-3-methyl-5-(6-methyl-5-((2-(1-methyl-1h-pyrazol-4-yl)pyridin-4-yl)oxy)pyridin-2-yl)pyrimidin-4(3h)-one · 3-methyl-2-((1-methylethyl)amino)-5-(6-methyl-5-((2-(1-methyl-1h-pyrazol-4-yl)-4-pyridinyl)oxy)-2-pyridinyl)-4(3h)-pyrimidinone · 4(3h)-pyrimidinone, 3-methyl-2-((1-methylethyl)amino)-5-(6-methyl-5-((2-(1-methyl-1h-pyrazol-4-yl)-4-pyridinyl)oxy)-2-pyridinyl)-
- Code names
- DCC-3014 · DP-6865
- Brand names
Resolves to
TVGAHWWPABTBCX-UHFFFAOYSA-NSMILESCC(C)NC1=NC=C(C(=O)N1C)C1=CC=C(OC2=CC=NC(=C2)C2=CN(C)N=C2)C(C)=N1What you can answer from here — as of September 20, 2026
Which drugs share a target with Vimseltinib, and which of those have an active Phase 3 trial?
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