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Zastaprazan
go.drugbank.com/drugs/DB21524InvestigationalZastaprazan is a small molecule drug. The usage of the INN stem '-prazan' in the name indicates that Zastaprazan is a proton pump inhibitor, not dependent on acid activation. Zastaprazan is under investigation in clinical trial NCT058148...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 SubstratesLimnetrelvir
go.drugbank.com/drugs/DB21677ExperimentalLimnetrelvir is a small molecule drug. The usage of the INN stem '-trelvir' in the name indicates that Limnetrelvir is a antiviral 3CL protease inhibitor. Limnetrelvir has a monoisotopic molecular weight of 557.17 Da.
Categories: Cytochrome P-450 CYP3A Inhibitors, Cytochrome P-450 SubstratesSorbitan monolaurate
go.drugbank.com/drugs/DB20157InvestigationalSorbitan monolaurate is a small molecule drug. Sorbitan monolaurate has a monoisotopic molecular weight of 346.24 Da.
Categories: P-glycoprotein inhibitorsEnerisant
go.drugbank.com/drugs/DB20605ExperimentalThe usage of the INN stem '-isant' in the name indicates that Enerisant is a histamine H3 receptor antagonist. Enerisant has a monoisotopic molecular weight of 398.23 Da.
Categories: P-glycoprotein substratesBesigomsin
go.drugbank.com/drugs/DB20894ExperimentalBesigomsin is a small molecule drug. Besigomsin has a monoisotopic molecular weight of 416.18 Da.
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesFluorometholone
go.drugbank.com/drugs/DB00324ApprovedInvestigationalA glucocorticoid employed, usually as eye drops, in the treatment of allergic and inflammatory conditions of the eye. It has also been used topically in the treatment of various skin disorders. (From Martindale, The Extra Pharmacopoeia, ...
Categories: Corticosteroid Hormone Receptor Agonists, Cytochrome P-450 SubstratesTerfenadine
go.drugbank.com/drugs/DB00342ApprovedWithdrawnIn the U.S., Terfenadine was superseded by fexofenadine in the 1990s due to the risk of cardiac arrhythmia caused by QT interval prolongation.
Synonyms: (RS)-1-(4-tert-butylphenyl)-4-{4-[hydroxy(diphenyl)methyl]piperidin-1-yl}-butan-1-olCategories: P-glycoprotein inhibitors, P-glycoprotein substratesClobazam
go.drugbank.com/drugs/DB00349ApprovedIllicitInvestigational[A256868] Additionally, clobazam is believed to be a partial agonist to the GABA<sub>A</sub> receptor rather than non-selective full receptor agonists like 1,4-benzodiazepines, thus potentially explaining … [A256963,A256868] This is likely because of clobazam's higher affinity to the α<sub>2</sub> subunit of the GABA<sub>A</sub> receptor, which mediates anxiolytic effects, than the α<sub>1</sub> subunit,
Categories: GABA-A Receptor Agonists, P-glycoprotein substratesMefloquine
go.drugbank.com/drugs/DB00358ApprovedMalaria is a protozoan disease that places an enormous burden on human health in endemic areas around the world. The 2020 World Health Organization malaria report indicates a 60% decrease in the global malaria fatality rate between 2000 ...
Categories: P-glycoprotein inhibitors, P-glycoprotein substratesSulfadiazine
go.drugbank.com/drugs/DB00359ApprovedInvestigationalVet approvedOne of the short-acting sulfonamides used in combination with pyrimethamine to treat toxoplasmosis in patients with acquired immunodeficiency syndrome and in newborns with congenital infections.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C8 Substrates