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Difluprednate
go.drugbank.com/drugs/DB06781ApprovedInvestigationalDifluprednate is a topical corticosteroid indicated for the treatment of infammation and pain associated with ocular surgery. It is a butyrate ester of 6(α), 9(α)-difluoro prednisolone acetate.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesProducts: Otec % 0,05 Göz Damlası, Emülsiyon (5 mL), DİFLUNAT POMAT, 20 GCrizotinib
go.drugbank.com/drugs/DB08865ApprovedInvestigationalCrizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase (ALK) or ROS1-positive non-small cell lung cancer (NSCLC) tumors, as well as ALK-positive anaplastic … [L42460] By targeting the echinoderm microtubule-associated protein-like 4 (EML4)-ALK fusion protein, crizotinib offers robust effectiveness in treating NSCLC in patients with this type of rearrangement
Synonyms: (R)-crizotinibCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2B6 InhibitorsZotepine
go.drugbank.com/drugs/DB09225ApprovedWithdrawnZotepine, with the formula (2-chloro-11-(2-dimethyl-amino-ethoxy)-dibenzo thiepin, is a neuroleptic drug. It was designed and synthesized by Fujisawa Pharmaceutical Co Ltd. … [A31855] It has been used as an antipsychotic in Japan, India and some places in Europe like UK and Germany since 1980's.[A31857] Zotepine was never approved by the FDA.
Categories: Serotonin 5-HT2 Receptor Antagonists, Serotonin 5-HT2A Receptor AntagonistsProducts: ZOLEPTIL © 50 MG TABLETAS RECUBIERTAS.Selpercatinib
go.drugbank.com/drugs/DB15685ApprovedInvestigationalSelpercatinib is a kinase inhibitor with enhanced specificity for RET tyrosine kinase receptors (RTKs) over other RTK classes. … [A202055, A202052, L13604] Enhanced RET (Rearranged during transfection) oncogene expression is a hallmark of many cancers.
Synonyms: 6-(2-hydroxy-2-methylpropoxy)-4-(6-(6-((6-methoxypyridin-3-yl)methyl)-3,6-diazabicyclo[3.1.1]heptan-3-yl)pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carbonitrileCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C8 InhibitorsRamosetron
go.drugbank.com/drugs/DB09290InvestigationalRamosetron is a _serotonin 5-HT3 receptor antagonist_ commonly employed to treat nausea and vomiting, in addition to certain diarrheal conditions. … It is believed to have higher potency and longer antiemetic action than other 1st generation 5-HT3 antagonists such as ondansetron.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 SubstratesProducts: IRRIBOW TABLET 5 MCG, NASEA(R) TABLET 0.1 MGDactylis glomerata pollen
go.drugbank.com/drugs/DB10379ApprovedDactylis glomerata pollen is the pollen of the Dactylis glomerata plant. Dactylis glomerata pollen is mainly used in allergenic testing.
Mixtures: 7 Grass Mix, 7 Grass MixProducts: Standardized Grass Pollen - Orchard Grass (100 Bau/ml), Standardized Grass Pollen - Orchard Grass (100000 Bau/ml)Pentamidine
go.drugbank.com/drugs/DB00738ApprovedInvestigationalAntiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of pneumocystis pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other t...
Synonyms: p,p'-(pentamethylenedioxy)dibenzamidine, 1,5-bis(4-amidinophenoxy)pentaneCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesTetrofosmin
go.drugbank.com/drugs/DB11180ApprovedIt presents a molecular formula of 1,2-bis(bis(2-ethoxyethyl)phosphino)ethane. Tetrofosmin is part of the group of diphosphines. … Tetrofosmin is used in conjunction with technetium Tc-99m as a radiopharmaceutical.[A7788]
Mixtures: Tetrofosmin ROTOP 0,23 mg Kit für ein radioaktives ArzneimittelCategories: P-glycoprotein substratesAlpelisib
go.drugbank.com/drugs/DB12015ApprovedInvestigationalAlpelisib is a phosphatidylinositol 3-kinase (PI3K) inhibitor with potent antitumor activity. … Alpelisib was designed to target this enzyme that appears to be mutated at a rate of nearly 30% in human cancers, leading to hyperactivation.
Categories: Class I Phosphatidylinositol 3-Kinases, antagonists & inhibitors, Phosphatidylinositol-3-kinase (Pi3K) inhibitorsProducts: PİMREVA 200 MG FİLM KAPLI TABLET, 14 ADET, PİMREVA 200 MG FİLM KAPLI TABLET, 28 ADETBrentuximab vedotin
go.drugbank.com/drugs/DB08870ApprovedInvestigationalBrentuximab vedotin, also known as Adcetris®, is an antibody-drug conjugate that combines an anti-CD30 antibody with the drug monomethyl auristatin E (MMAE). … [L1737] The ECHELON-1 study results demonstrated superior efficacy of the drug combined with a chemotherapy regimen compared to the previous standard of care.
Synonyms: Monoclonal antibody SGN-30, Moab, chimeric, SGN-30, to CD30 antigenCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Inhibitors