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Exatecan
go.drugbank.com/drugs/DB12185InvestigationalExatecan has been used in trials studying the treatment of Sarcoma, Leukemia, Lymphoma, Lung Cancer, and Liver Cancer, among others.
Categories: Topoisomerase I InhibitorsAdenosine-5'-Monophosphate Glucopyranosyl-Monophosphate Ester
go.drugbank.com/drugs/DB01774ExperimentalServes as the glycosyl donor for formation of bacterial glycogen, amylose in green algae, and amylopectin in higher plants. [PubChem]
Synonyms: Adenosine-5'-Monophosphate Glucopyranosyl-Monophosphate EsterIpratropium
go.drugbank.com/drugs/DB00332ApprovedInvestigational[A176939] It is commonly administered through inhalation which allows producing a local effect without presenting a significant systemic absorption. … Ipratropium is a quaternary ammonium derivative of [atropine][A176957] that acts as an anticholinergic agent.
Mixtures: BERODUAL® HFA, BERODUAL® HFAProducts: Atrovent ® 0.025% Nebuliser Solution, BRIA®Nuclear factor NF-kappa-B p105 subunit
go.drugbank.com/bio_entities/BE0001086TargetHumansNF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as in...
Synonyms: Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1Tail spike protein
go.drugbank.com/bio_entities/BE0001295TargetEnterobacteria phage P22Structural component of the short non-contractile tail. The tail comprises six spikes that mediate primary attachment to the host cell lipopolysaccharides (LPS) and display endorhamnosidase enzymatic activity, hydrolyzing the alpha-1,3-O...
Synonyms: Gene product 9StAR-related lipid transfer protein 3
go.drugbank.com/bio_entities/BE0014576TransporterHumansSterol-binding protein that mediates cholesterol transport from the endoplasmic reticulum to endosomes (PubMed:11053434, PubMed:15930133, PubMed:22514632, PubMed:28377464, PubMed:33124732). The sterol transport mechanism is triggered by ...
Synonyms: Metastatic lymph node gene 64 proteinFerroptosis suppressor protein 1
go.drugbank.com/bio_entities/BE0018843TargetEnzymeHumansA NAD(P)H-dependent oxidoreductase that acts as a key inhibitor of ferroptosis (PubMed:31634899, PubMed:31634900, PubMed:35922516, PubMed:36788244, PubMed:37957306, PubMed:39881208, PubMed:37739993, PubMed:39160155, PubMed:38414669, PubM...
Synonyms: p53-responsive gene 3 proteinATP-binding cassette sub-family C member 8
go.drugbank.com/bio_entities/BE0000207TargetTransporterHumansRegulator subunit of pancreatic ATP-sensitive potassium channel (KATP), playing a major role in the regulation of insulin release. In pancreatic cells, it forms KATP channels with KCNJ11; KCNJ11 forms the channel pore while ABCC8 is requ...
Synonyms: Sulfonylurea receptor 1PF-00489791
go.drugbank.com/drugs/DB11736InvestigationalPF-00489791 has been used in trials studying the treatment of Hypertension, Raynaud's Disease, Diabetic Nephropathies, Hypertension, Pulmonary, and Peripheral Vascular Disease.
TG-1042
go.drugbank.com/drugs/DB18435InvestigationalTG-1042 (formerly known as ASN-002) is a recombinant adenovirus carrying the cDNA coding sequence for the human interferon gamma gene.