Search

Displaying results 3461 - 3470 of 10000 in total
  1. Drug

    Dolichovespula maculata venom protein

    go.drugbank.com/drugs/DB10958
    Approved

    Dolichovespula maculata venom protein is an extract of Dolichovespula maculata venom. Dolichovespula maculata venom protein is used in allergenic testing.

    Mixtures: Hymenoptera Venom Product-mixed Vespid Venom Protein (1650 Mcg), Mixed Vespid Venom Protein Multidose 13.0 Ml (3900 Mcg)Products: Hymenoptera Venom Product-white-faced Hornet Venom Protein (550 Mcg), Venomil Inj 10mcg/ml White Faced Hornet
  2. Drug

    Apalutamide

    go.drugbank.com/drugs/DB11901
    ApprovedInvestigational

    In a phase-2 multicenter open-label study, 89% of patients with non-metastatic, castration-resistant prostate cancer had ≥50% PSA decline at week 12 of apalutamide treatment [A31846]. … Approximately 10 to 20 % of prostate cancer cases are castration-resistant, and up to 16% of these patients show no evidence of cancer metastasis at the time of castration-resistant diagnosis [L1295].

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C19 InducersProducts: ERLEADA ®TABLETAS RECUBIERTAS 60 MG
  3. Drug

    Benmelstobart

    go.drugbank.com/drugs/DB17473
    Investigational

    APL 502 is a humanised immunoglobulin G1 (IgG1) monoclonal antibody targeting the programmed cell death-1 ligand-1 (PD-L1).

    Synonyms: , G1v66 CH2 A27 (CH1 K120(213) (117-214), hinge 1-15, gamma1 heavy chain humanized (1-446) [VH (Homo sapiens IGHV2-5*01 (78.6%) -(IGHD) -IGHJ4*01 (100%), CDR-IMGT [8.7.10] (26-33.51-57.96-105)) (1-116)-Homo sapiens IGHG1*01, G1m17,1 CH1 K120, CH3 D12, L14
  4. Drug

    Acenocoumarol

    go.drugbank.com/drugs/DB01418
    ApprovedInvestigational

    Acenocoumarol is a coumarin derivative used as an anticoagulant. Coumarin derivatives inhibit the reduction of vitamin K by vitamin K reductase. … This prevents carboxylation of vitamin K-dependent clotting factors, II, VII, IX and X, and interferes with coagulation.

    Synonyms: 4-Hydroxy-3-[1-(4-nitrophenyl)-3-oxobutyl]-2H-chromen-2-one, 4-Hydroxy-3-(1-(4-nitrophenyl)-3-oxobutyl)-2H-1-benzopyran-2-oneCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 Substrates
  5. Drug

    Tocainide

    go.drugbank.com/drugs/DB01056
    ApprovedWithdrawn

    An antiarrhythmic agent which exerts a potential- and frequency-dependent block of sodium channels.

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 InhibitorsSynonyms: 2-Amino-2',6'-propionoxylidide, 2-amino-N-(2,6-dimethylphenyl)propanamide
  6. Target

    Deoxycytidylate 5-hydroxymethyltransferase

    go.drugbank.com/bio_entities/BE0003183
    TargetEnterobacteria phage T4

    Polypeptides: Deoxycytidylate 5-hydroxymethyltransferaseFunction: deoxycytidylate 5-hydroxymethyltransferase activity
  7. Target

    Histone deacetylase 5

    go.drugbank.com/bio_entities/BE0009578
    TargetHumans

    In vitro, it deacetylates lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (PubMed:10220385). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional reg...

    Polypeptides: Histone deacetylase 5
  8. Target

    Melanocortin receptor 5

    go.drugbank.com/bio_entities/BE0009684
    TargetHumans

    G protein-coupled receptor for melanocyte-stimulating hormones (alpha- beta- and gamma-MSH) and corticotropin/ACTH, which are peptide products of the POMC precursor (PubMed:37524700, PubMed:8396929). Upon activation, couples to G(s) prot...

    Polypeptides: Melanocortin receptor 5
  9. Target

    Pepsin A-5

    go.drugbank.com/bio_entities/BE0009737
    TargetHumans

    Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent

    Polypeptides: Pepsin A-5Synonyms: Pepsinogen-5
  10. Target

    Integrin beta-5

    go.drugbank.com/bio_entities/BE0012746
    TargetHumans

    Integrin alpha-V/beta-5 (ITGAV:ITGB5) is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligand

    Polypeptides: Integrin beta-5