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Displaying results 3481 - 3490 of 3735 in total

Drug
Clonidine
go.drugbank.com/drugs/DB00575
ApprovedInvestigational
Clonidine is an imidazole derivate that acts as an agonist of alpha-2 adrenoceptors. This activity is useful for the treatment of hypertension, severe pain, and ADHD. Clonidine was granted FDA approval on 3 September 1974.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Substrates
Drug
Lisuride
go.drugbank.com/drugs/DB00589
Approved
An ergot derivative that acts as an agonist at dopamine D2 receptors (dopamine agonists). It may also act as an antagonist at dopamine D1 receptors, and as an agonist at some serotonin receptors (serotonin agonists).
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Substrates
Drug
Fluocinolone acetonide
go.drugbank.com/drugs/DB00591
ApprovedInvestigationalVet approved
Fluocinolone acetonide, with the formula 6-alpha, 9-alpha-difluoro-16-alpha, 17 alpha-acetonide, is a corticosteroid that presents a high lipophilicity. It has been used extensively in dermatological preparations and it has also been inv...
Categories: Corticosteroid Hormone Receptor Agonists, Cytochrome P-450 Substrates
Drug
Labetalol
go.drugbank.com/drugs/DB00598
ApprovedInvestigational
Labetalol is a racemic mixture of 2 diastereoisomers where dilevalol, the R,R' stereoisomer, makes up 25% of the mixture. Labetalol is formulated as an injection or tablets to treat hypertension. Labetalol was granted FDA approval on 1 A...
Categories: Cytochrome P-450 Substrates, Adrenergic alpha-1 Receptor Antagonists
Drug
Thiopental
go.drugbank.com/drugs/DB00599
ApprovedInvestigationalVet approvedWithdrawn
A barbiturate that is administered intravenously for the induction of general anesthesia or for the production of complete anesthesia of short duration. It is also used for hypnosis and for the control of convulsive states. It has been u...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Inducers
Drug
Fluphenazine
go.drugbank.com/drugs/DB00623
Approved
A phenothiazine used in the treatment of psychoses. Its properties and uses are generally similar to those of chlorpromazine.
Categories: P-glycoprotein inhibitors, Cytochrome P-450 CYP2D6 Inhibitors
Drug
Sumatriptan
go.drugbank.com/drugs/DB00669
ApprovedInvestigational
Sumatriptan is a serotonin receptor agonist commonly used to treat migraines and sometimes cluster headaches.
Categories: P-glycoprotein substrates, Serotonin Receptor Agonists
Drug
Chlorpropamide
go.drugbank.com/drugs/DB00672
ApprovedWithdrawn
Medications in this class differ in their dose, rate of absorption, duration of action, route of elimination and binding site on their target pancreatic β cell receptor.
Synonyms: 1-(p-chlorobenzenesulfonyl)-3-propylurea, 1-(p-chlorophenylsulfonyl)-3-propylureaCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C9 Substrates
Drug
Tamoxifen
go.drugbank.com/drugs/DB00675
ApprovedInvestigational
Tamoxifen is a non-steroidal antiestrogen used to treat estrogen receptor positive breast cancers as well as prevent the incidence of breast cancer in high risk populations.
Synonyms: 1-p-beta-Dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-eneCategories: Estrogen Receptor Modulators, Selective Estrogen Receptor Modulators
Drug
Thioridazine
go.drugbank.com/drugs/DB00679
ApprovedWithdrawn
A phenothiazine antipsychotic used in the management of psychoses, including schizophrenia, and in the control of severely disturbed or agitated behavior. It has little antiemetic activity. Thioridazine has a higher incidence of antimusc...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 Inhibitors