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Displaying results 341 - 350 of 1186 in total
  1. Target

    Ryanodine receptor 2

    go.drugbank.com/bio_entities/BE0005295
    TargetTransporterHumans

    Cytosolic calcium-activated calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytosol and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead ...

    Polypeptides: Ryanodine receptor 2Synonyms: Type 2 ryanodine receptor, Cardiac muscle ryanodine receptor
  2. Target

    Apolipoprotein B receptor

    go.drugbank.com/bio_entities/BE0005852
    TargetTransporterHumans

    Macrophage receptor that binds to the apolipoprotein B48 (APOB) of dietary triglyceride (TG)-rich lipoproteins (TRL) or to a like domain of APOB in hypertriglyceridemic very low density lipoprotein (HTG-VLDL

    Polypeptides: Apolipoprotein B receptorSynonyms: Apolipoprotein B-100 receptor, Apolipoprotein B-48 receptor
  3. Target

    Melanocortin receptor 4

    go.drugbank.com/bio_entities/BE0009682
    TargetHumans

    G protein-coupled receptor that binds melanocyte-stimulating hormones (alpha- and beta-MSH) and corticotropin/ACTH, which are peptide products of the POMC precursor (PubMed:12646665, PubMed:14764818, PubMed

    Polypeptides: Melanocortin receptor 4Function: corticotropin receptor activity
  4. Target

    Prosaposin receptor GPR37

    go.drugbank.com/bio_entities/BE0011479
    TargetHumans

    Acts as a receptor for several ligands including prosaposin, osteocalcin or neuroprotectin D1. … Acts as a receptor for osteocalcin (OCN) to regulate oligodendrocyte differentiation and central nervous system myelination.

    Polypeptides: Prosaposin receptor GPR37Synonyms: Parkin-associated endothelin receptor-like receptor, G protein-coupled receptor 37
  5. Target

    Relaxin receptor 1

    go.drugbank.com/bio_entities/BE0019700
    TargetHumans

    Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP.

    Polypeptides: Relaxin receptor 1Synonyms: Leucine-rich repeat-containing G protein-coupled receptor 7, Relaxin family peptide receptor 1
  6. Target

    Urotensin-2 receptor

    go.drugbank.com/bio_entities/BE0020904
    TargetHumans

    G protein-coupled receptor for the vasoactive neuropeptides urotensin-2 and urotensin-2B (PubMed:14550283).

    Polypeptides: Urotensin-2 receptorSynonyms: Urotensin II receptor, G protein-coupled receptor 14
  7. Drug

    Defibrotide

    go.drugbank.com/drugs/DB04932
    ApprovedInvestigational

    Defibrotide is the sodium salt of a mixture of single-stranded oligodeoxyribonucleotides derived from porcine mucosal DNA. It has been shown to have antithrombotic, anti-inflammatory and anti-ischemic properties (but without associated s...

  8. Drug

    Dopamine

    go.drugbank.com/drugs/DB00988
    ApprovedInvestigational

    One of the catecholamine neurotransmitters in the brain. It is derived from tyrosine and is the precursor to norepinephrine and epinephrine. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regu...

  9. Drug

    Sabestomig

    go.drugbank.com/drugs/DB19326
    Investigational

    Sabestomig is under investigation in clinical trial NCT05216835 (Safety and Preliminary Efficacy Assessment of AZD7789 in Patients With Relapsed or Refractory Classical Hodgkin Lymphoma).

    Synonyms: Immunoglobulin G1-kappa/lambda, anti-[Homo sapiens PDCD1 (programmed cell death 1, PD1, PD-1, CD279) and HAVCR2 (hepatitis A virus cellular receptor 2, T cell immunoglobulin and mucin domains family member
  10. Drug

    Black cohosh

    go.drugbank.com/drugs/DB13975
    ApprovedInvestigational

    Black cohosh (Actaea racemosa or Cimicifuga racemosa), a member of the buttercup family, is a perennial plant which native to North America. Historical names for this plant include snakeroot, black bugbane, rattleweed, macrotys, and rheu...