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ZEN-012
go.drugbank.com/drugs/DB06042ExperimentalZEN-012 is a novel small molecule and the first anti-cancer drug in development involving two mechanisms of action: tubulin and topoisomerase II inhibition. … ZEN-012 also expresses additional modes of action such as pro-apoptotic and anti-angiogenic properties. It is developed for the treatment of solid tumors.
Limaprost
go.drugbank.com/drugs/DB09211InvestigationalIt also improves poor blood flow in the nerve tissue in cervical spondylosis and normalizes nerve function. … study in patients with the disease.
Categories: Prostaglandins EIodohippuric acid
go.drugbank.com/drugs/DB15445InvestigationalIodohippuric acid is under investigation in clinical trial NCT02599844 (Impact of Pediatric Acute Renal Injury in Severe Sepsis in Young Adults).
Categories: Compounds used in a research, industrial, or household settingTechnetium Tc-99m red blood cells
go.drugbank.com/drugs/DB09493ApprovedWithdrawnAutologous red blood cells are radiolabeled with sodium pertechnetate Tc 99m in the reaction vial. … It is clinically useful in early detection and localization of bleeding sites, and preoperative diagnosis of hemangioma [A32178, A32179].
Tilactase
go.drugbank.com/drugs/DB13761ApprovedInvestigationalTilactase is a beta-D-galactosidase obtained from Aspergillus oryzae. It is produced as a chewable tablet that has to be taken before the consumption of a lactose-containing meal. The beta-D-galactosidase us a large monomeric multi-domai...
Bithionol
go.drugbank.com/drugs/DB04813ApprovedWithdrawnBithionol, formerly marketed as an active ingredient in various topical drug products, was shown to be a potent photosensitizer with the potential to cause serious skin disorders. … Approvals of the NDA's for bithionol drug products were withdrawn on October 24, 1967 (see the Federal Register of October 31, 1967 (32 FR 15046)).
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
go.drugbank.com/bio_entities/BE0000176TargetEnzymeHumansFlavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone
Synonyms: Flavoprotein subunit of complex IINADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7
go.drugbank.com/bio_entities/BE0000512TargetHumansAccessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. … Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Synonyms: Complex I-B18Somapacitan
go.drugbank.com/drugs/DB15093ApprovedInvestigational[A219146] Somapacitan was granted FDA approval on 28 August 2020.[L15666] … [A219126,L15661] This human growth hormone analog differs by the creation of an albumin binding site, and prolonging the effect so that it requires weekly dosing rather than daily.
Oxtriphylline
go.drugbank.com/drugs/DB01303ApprovedIn the US, oxtriphylline is no longer available. … Once in the body, theophylline is released and acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator.