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Runt-related transcription factor 1
go.drugbank.com/bio_entities/BE0010423TargetHumansForms the heterodimeric complex core-binding factor (CBF) with CBFB. … RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their
Synonyms: Core-binding factor subunit alpha-2, SL3/AKV core-binding factor alpha B subunitMaltose
go.drugbank.com/drugs/DB03323InvestigationalA dextrodisaccharide from malt and starch. It is used as a sweetening agent and fermentable intermediate in brewing (Grant & Hackh's Chemical Dictionary, 5th ed).
Categories: Compounds used in a research, industrial, or household settingNetilmicin
go.drugbank.com/drugs/DB00955ApprovedNetilmicin is a semisynthetic 1-N-ethyl derivative of sisomycin, an aminoglycoside antibiotic with action similar to gentamicin, but less ear and kidney toxicity. … Netilmicin inhibits protein synthesis in susceptible organisms by binding to the bacterial 30S ribosomal subunit and interfering with mRNA binding and the acceptor tRNA site.
Categories: Drugs that are Mainly Renally Excreted with a Narrow Therapeutic IndexSynonyms: 1-N-EthylsisomicinProtein S100-A8
go.drugbank.com/bio_entities/BE0008955TargetHumansActivates NADPH-oxidase by facilitating the enzyme complex assembly at the cell membrane, transferring arachidonic acid, an essential cofactor, to the enzyme complex and S100A8 contributes to the enzyme … The iNOS-S100A8/A9 transnitrosylase complex directs selective inflammatory stimulus-dependent S-nitrosylation of GAPDH and probably multiple targets such as ANXA5, EZR, MSN and VIM by recognizing a [IL
Synonyms: Leukocyte L1 complex light chainVerpasep caltespen
go.drugbank.com/drugs/DB04959InvestigationalE7 protein is involved in carcinogenesis of anal and cervical tumors, and represents a tumor antigen that may be specifically targeted by lymphocytes. … Verpasep caltespen is a recombinant chimeric protein composed of the heat shock protein 65 (Hsp65) from _Mycobacterium bovis_, and the human papilloma viral (HPV) protein E7.
Synonyms: BCG65-E7, HPV 16 E7/HSP65 vaccineArsanilic acid
go.drugbank.com/drugs/DB03006ExperimentalVet approvedAn arsenical which has been used as a feed additive for enteric conditions in pigs and poultry. It causes blindness and is ototoxic and nephrotoxic in animals. [PubChem]
Categories: Compounds used in a research, industrial, or household setting105AD7
go.drugbank.com/drugs/DB05113Investigational105AD7 is a human monoclonal antibody that mimics the complement regulatory protein, CD55, overexpressed by many solid tumours including osteosarcoma. 105AD7 induced antitumour inflammatory responses in … metastatic colorectal cancer patients. 105AD7 may be a suitable vaccine for treatment of this disease.
Pimagedine
go.drugbank.com/drugs/DB05383InvestigationalIt is an advanced glycation end product inhibitor which manages diabetic nephropathy, either alone or in combination with other therapies. … It is beneficial in treating patients with diabetic nephropathy.
Sutilain
go.drugbank.com/drugs/DB09379ApprovedWithdrawn[T169] Sutilain was developed by Abbott and FDA approved on June 12, 1969. It is currently discontinued.[L2368] … Sutilain contains proteolytic enzymes derived from _Bacillus subtilis_ and it is available as a cream-colored odorless powder.
Ladarixin
go.drugbank.com/drugs/DB16212InvestigationalLadarixin is under investigation in clinical trial NCT04628481 (A Study of Oral Ladarixin in New-onset Type 1 Diabetes and a Low Residual Β-Cell Function).
Categories: Receptors, Interleukin-8A, antagonists & inhibitors