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NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10
go.drugbank.com/bio_entities/BE0000245TargetHumansAccessory subunit that is involved in the functional assembly of the mitochondrial respiratory chain complex I. Complex I has an NADH dehydrogenase activity with ubiquinone as an immediate electron acceptor and mediates the transfer of e...
Polypeptides: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10ATP-binding cassette sub-family C member 10
go.drugbank.com/bio_entities/BE0003651TransporterHumansIn RNA virus-infected cells, oligoadenylate synthase senses viral dsRNA and generates 2',5'-oligoadenylates (2-5A) which act as second messengers to activate RNASEL and type I interferon signaling to inhibit
Polypeptides: ATP-binding cassette sub-family C member 10Milnacipran
go.drugbank.com/drugs/DB04896ApprovedInvestigational(BACE-1), which has investigationally been associated with β-amyloid plaque formation - making the agent a possible course of treatment for Alzheimer's disease [A175957]. … Moreover, recent research has shown that the levorotatory enantiomer of milnacipran, levomilnacipran, may have the capacity to inhibit the activity of beta-site amyloid precursor protein cleaving enzyme-1
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InhibitorsProducts: Ixel 50 mg - Kapseln, IXEL 50 MG KAPSUL, 56 ADETVasopressin
go.drugbank.com/drugs/DB00067ApprovedInvestigationalthrough V<sub>1</sub> and V<sub>2</sub> cellular receptors. … [A228013] It is currently marketed under the trademark VASOSTRICT® by PAR Pharmaceuticals.[L31413]
Products: VASOPRESSIN INJECTION USP 20 u/ml, VASOPRESINA INYECTABLE 20 U/ML USPPrimaquine
go.drugbank.com/drugs/DB01087ApprovedInvestigational(From Martindale, The Extra Pharmacopeia, 30th ed, p404) … It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria.
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesSynonyms: 6-Methoxy-8-(4-amino-1-methylbutylamino)quinoline, 8-((4-Amino-1-methylbutyl)amino)-6-methoxyquinolineTrastuzumab deruxtecan
go.drugbank.com/drugs/DB14962ApprovedInvestigationalTrastuzumab deruxtecan is a HER2-directed antibody attached to a topoisomerase inhibitor that is approved for use in certain types of treatment-resistant HER2-positive cancers. … [L10842] It is classified as an antibody-drug conjugate. The cleavable peptide linker used to bind the antibody and drug in this product distinguishes it from other members of its class.
Categories: MATE 2 Substrates, P-glycoprotein substratesSynonyms: T-DXd, T- DXdC-type lectin domain family 10 member A
go.drugbank.com/bio_entities/BE0016623TargetHumansantigens, including alphaGalNAc- and Galbeta1->3GalNAc-O-Ser/Thr also known as Tn and T antigens, LacdiNAc epitope GalNAcbeta1->4GlcNAc and its derivative GalNAcbeta1->4-(Fucalpha1->3)GlcNAc, O-linked core 5
Polypeptides: C-type lectin domain family 10 member APomalidomide
go.drugbank.com/drugs/DB08910ApprovedInvestigationalFDA approved on February 8, 2013.
Categories: Heterocyclic Compounds, 1-Ring, P-glycoprotein substrates with a Narrow Therapeutic IndexProducts: POMALYST 1 MG, POMALYST ® 1 MGMelphalan
go.drugbank.com/drugs/DB01042ApprovedInvestigational[L40928] It was first synthesized in the early 1950s by substituting L-phenylalanine for the methyl group on nitrogen mustard. … Melphalan is a nitrogen mustard or bischloroethylamine type alkylating agent.
Synonyms: 3-(p-(Bis(2-chloroethyl)amino)phenyl)-L-alanine, 3-p-(Di(2-chloroethyl)amino)-phenyl-L-alanineProducts: ALKERAN FOR INJECTION 50 mg/vial, ERİOLAN 50 MG ENJEKSİYONLUK/İNFÜZYONLUK ÇÖZELTİ İÇİN LİYOFİLİZE TOZ VE ÇÖZÜCÜ, 1 ADET LİYOFİLİZE TOZ İÇEREN FLAKON+1 ADET ÇÖZÜCÜ İÇEREN FLAKONHuman C1-esterase inhibitor
go.drugbank.com/drugs/DB06404ApprovedInvestigationalC1 Esterase Inhibitor (Human) is composed of purified endogenous complement component-1 esterase inhibitor (hC1INH) isolated from human plasma. … [L16586, L16606] This drug is indicated for prophylaxis and treatment of Hereditary Angioedema (HAE), a human genetic disorder caused by a shortage of C1 inhibitor activity that results in an overreaction
Products: CİNRYZE 500 IU/5 ML IV ENJEKSİYONLUK ÇÖZELTİ İÇİN LİYOFİLİZE TOZ VE ÇÖZÜCÜ, 2 ADET