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Zinc transporter ZIP10
go.drugbank.com/bio_entities/BE0009884TransporterHumansSLC39A10-SLC39A6 heterodimers play also an essential role in initiating mitosis by importing zinc into cells to initiate a pathway resulting in the onset of mitosis (PubMed:32797246). … Plays an important for both mature B-cell maintenance and humoral immune responses (By similarity).
Synonyms: Zrt- and Irt-like protein 10Diffuse Large B-Cell Lymphoma, Not Otherwise Specified
go.drugbank.com/conditions/DBCOND0080506Drugs: Polatuzumab vedotinSynonyms: Malignant lymphoma, large cell, cleaved and noncleaved, Malignant lymphoma - large cell cleaved and non-cleavedBetula pendula tar oil
go.drugbank.com/drugs/DB11361ApprovedNutraceuticalThis oil is usually obtained by using both hydrodistillation and micro-distillation[A33154] and it is conformed mainly by [DB11143] and [DB11359]. … Betula pendula tar oil is an essential oil found in the buds of the plant with the same name.
Mechlorethamine
go.drugbank.com/drugs/DB00888ApprovedInvestigationalThe hydrochloride is used as an antineoplastic in Hodgkin's disease and lymphomas. It causes severe gastrointestinal and bone marrow damage. … A vesicant and necrotizing irritant destructive to mucous membranes, mechlorethamine is an alkylating drug. It was formerly used as a war gas.
Categories: Antineoplastic and Immunomodulating Agents, Compounds used in a research, industrial, or household settingSynonyms: 2,2'-dichloro-N-methyldiethylamine, N-methyl-bis(2-chloroethyl)amineAcamprosate
go.drugbank.com/drugs/DB00659ApprovedInvestigationalIt was first approved by the FDA in 2004 and initially marketed by Forest Laboratories.[L31783] … [L31758] Acamprosate is the first medication specifically formulated for the maintenance of alcohol abstinence in ethanol-dependent patients after alcohol detoxification[A997], unlike [naltrexone] and
Categories: Drugs Used in Addictive Disorders, Drugs Used in Alcohol DependenceSynonyms: N-Acetylhomotaurine, N-acetyl homotaurineSodium phosphate, dibasic, unspecified form
go.drugbank.com/drugs/DB14504ApprovedMixtures: Up and Up Ready To Use Enema, Aminosyn II in DextroseDanicopan
go.drugbank.com/drugs/DB15401ApprovedInvestigationalParoxysmal nocturnal hemoglobinuria (PNH) is a rare acquired hematologic disease characterized by hemolysis, thrombophilia, and bone marrow dysfunction. … [A263506] It was subsequently approved by the FDA in March 2024.[L50386]
Categories: Amino Acids, Peptides, and Proteins, Antineoplastic and Immunomodulating AgentsSynonyms: (2S,4R)-1-(2-(3-acetyl-5-(2-methylpyrimidin-5-yl)-1H-indazol-1-yl)acetyl)-N-(6-bromopyridin-2-yl)-4-fluoropyrrolidine-2-carboxamide, (2S,4R)-1-(2-(3-acetyl-5-(2-methylpyrimidine-5-yl)-1H-indazol-1-yl)acetyl)-N-(6-bromopyridine-2-yl)-4-fluoropyrrolidine-2-carboxamideRNA-splicing ligase RTCB
go.drugbank.com/bio_entities/BE0004442TargetHumansIn the final step, the 5'-OH of the 3' exon attacks the activated 3' end of the 5' exon, forming a 3'-5' phosphodiester bond and releasing GMP (PubMed:24870230, PubMed:38493148). … These exon ends are then recognized and ligated by RTCB.
Synonyms: RNA 2',3'-cyclic phosphate and 5'-OH ligaseDaraxonrasib
go.drugbank.com/drugs/DB22308ApprovedInvestigational[L64040,L64041] It is taken by mouth once daily. … [L64039,L64041] Because it targets a broad range of RAS genotypes, it treats tumors with or without an identified RAS mutation and does not require a companion diagnostic test.
EB003
go.drugbank.com/drugs/DB18362ExperimentalEB003 is a CRISPR-based sequence-specific antimicrobial (SSAM) targeted against shiga toxin-producing _E. coli_.
Synonyms: Phage-derived, non-replicative delivery vector carrying a DNA payload encoding an RNA-guided nuclease that targets stx genes of Shiga toxin-producing Escherichia coli (STEC)